{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:27:44Z","timestamp":1773253664582,"version":"3.50.1"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS065188"],"award-info":[{"award-number":["NS065188"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184957","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T18:32:04Z","timestamp":1512585124000},"page":"e0184957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis"],"prefix":"10.1371","volume":"12","author":[{"given":"Hilmarie","family":"Muniz-Talavera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-1464","authenticated-orcid":true,"given":"Jennifer V.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0361-9230(01)00769-9","article-title":"The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals","volume":"57","author":"J Garcia-Verdugo","year":"2002","journal-title":"Brain Res Bull"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1097-0029(19980401)41:1<2::AID-JEMT2>3.0.CO;2-Z","article-title":"Ependymal development, proliferation, and functions: a review","volume":"41","author":"J Bruni","year":"1998","journal-title":"Microscopy Res Tech"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0173(85)90016-5","article-title":"Ependyma: normal and pathological. A review of the literature","volume":"356","author":"J Bruni","year":"1985","journal-title":"Brain Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00401-009-0624-y","article-title":"Ependymal cells: biology and pathology","volume":"119","author":"M Del Bigio","year":"2010","journal-title":"Acta Neuropathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1073\/pnas.0710000105","article-title":"CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain","volume":"105","author":"V Coskun","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cell.2006.10.041","article-title":"Postnatal deletion of Numb\/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche","volume":"127","author":"C Kuo","year":"2006","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1523\/JNEUROSCI.0171-11.2011","article-title":"Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb","volume":"31","author":"B Jacquet","year":"2011","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1242\/dev.067470","article-title":"Six3 is required for ependymal cell maturation","volume":"138","author":"A Lavado","year":"2011","journal-title":"Development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s13238-012-2098-2","article-title":"Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice","volume":"4","author":"X Peng","year":"2013","journal-title":"Protein Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.2555","article-title":"Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus","volume":"13","author":"F Tissir","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.200710162","article-title":"Mutations in Hydin impair ciliary motility in mice","volume":"180","author":"KF Lechtreck","year":"2008","journal-title":"J Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200611115","article-title":"Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility","volume":"176","author":"KF Lechtreck","year":"2007","journal-title":"J Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/hmg\/ddg122","article-title":"Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene","volume":"12","author":"BE Davy","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4067\/S0716-97602012000300005","article-title":"A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus","volume":"45","author":"E Rodriguez","year":"2012","journal-title":"Biol Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.1108-04.2005","article-title":"Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis","volume":"25","author":"N Spassky","year":"2005","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/cercor\/13.6.580","article-title":"Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment","volume":"13","author":"A Tramontin","year":"2003","journal-title":"Cereb Cortex"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1165\/ajrcmb.23.1.4070","article-title":"Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice","volume":"23","author":"S Brody","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1242\/dev.041129","article-title":"FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain","volume":"136","author":"BV Jacquet","year":"2009","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/ng.267","article-title":"The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos","volume":"40","author":"J Stubbs","year":"2008","journal-title":"Nat Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2046-2530-1-8","article-title":"Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: comparison with the photomultiplier and photodiode methods","volume":"1","author":"C O'Callaghan","year":"2012","journal-title":"Cilia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ydbio.2013.07.003","article-title":"Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus","volume":"382","author":"O Appelbe","year":"2013","journal-title":"Dev Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00401-011-0799-x","article-title":"New ependymal cells are born postnatally in two discrete regions of the mouse brain and support ventricular enlargement in hydrocephalus","volume":"121","author":"L Batiz","year":"2011","journal-title":"Acta Neuropathol"},{"key":"ref24","article-title":"Comprehensive Developmental Neuroscience: Patterning and cell type specification in the developing CNS and PNS","author":"JL Rubenstein","year":"2013"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1091\/mbc.12.3.589","article-title":"Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia","volume":"12","author":"P Taulman","year":"2001","journal-title":"Mol Biol Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11511","DOI":"10.1523\/JNEUROSCI.0182-12.2012","article-title":"Nuclear factor kappaB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation","volume":"32","author":"M Lattke","year":"2012","journal-title":"J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ajhg.2009.01.011","article-title":"Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities","volume":"84","author":"V Castleman","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/hmg\/11.6.715","article-title":"Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus","volume":"11","author":"I Ibanez-Tallon","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1038\/ncomms5888","article-title":"Basal foot MTOC organizes pillar MTs required for coordination of beating cilia","volume":"5","author":"D Clare","year":"2014","journal-title":"Nat Comm"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/hmg\/ddh219","article-title":"Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation","volume":"13","author":"I Ibanez-Tallon","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1002516","DOI":"10.1371\/journal.pgen.1002516","article-title":"MNS1 is essential for spermiogenesis and motile ciliary functions in mice","volume":"8","author":"J Zhou","year":"2012","journal-title":"PLoS Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1523\/JNEUROSCI.3744-09.2010","article-title":"Cilia organize ependymal planar polarity","volume":"30","author":"Z Mirzadeh","year":"2010","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.neuron.2014.06.022","article-title":"Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus","volume":"83","author":"S Ohata","year":"2014","journal-title":"Neuron"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1523\/JNEUROSCI.0067-14.2014","article-title":"Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity","volume":"34","author":"G Ying","year":"2014","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1091\/mbc.E09-04-0291","article-title":"Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus","volume":"20","author":"M Abouhamed","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1460-9568.2006.05002.x","article-title":"Durand, B. A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells","volume":"24","author":"D Baas","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00213941","article-title":"Differential immunocytochemical staining for glial fibrillary acidic (GFA) protein, S-100 protein and glutamine synthetase in the rat subcommissural organ, nonspecialized ventricular ependyma and adjacent neuropil","volume":"245","author":"M Didier","year":"1986","journal-title":"Cell Tissue Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9212","DOI":"10.1523\/JNEUROSCI.17-23-09212.1997","article-title":"Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord","volume":"17","author":"T Shibata","year":"1997","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/ng.263","article-title":"Foxj1 transcription factors are master regulators of the motile ciliogenic program","volume":"40","author":"X Yu","year":"2008","journal-title":"Nat Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm1699","article-title":"Regulation of cadherin-mediated adhesion in morphogenesis","volume":"6","author":"B Gumbiner","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrm2927","article-title":"Adherens junctions: from molecules to morphogenesis","volume":"11","author":"T Harris","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1242\/dev.015982","article-title":"Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis","volume":"135","author":"M Shindo","year":"2008","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"125295","DOI":"10.1155\/2012\/125295","article-title":"Regulation of adherens junction dynamics by phosphorylation switches","volume":"2012","author":"C Bertocchi","year":"2012","journal-title":"J Signal Transduct"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-94-007-4186-7_8","article-title":"Signaling from the adherens junction","volume":"60","author":"A McEwen","year":"2012","journal-title":"Subcell Biochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"a002899","DOI":"10.1101\/cshperspect.a002899","article-title":"Adherens junction: molecular architecture and regulation","volume":"1","author":"W Meng","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1101\/gad.1486806","article-title":"Cadherins in development: cell adhesion, sorting, and tissue morphogenesis","volume":"20","author":"J Halbleib","year":"2006","journal-title":"Genes Dev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-94-007-4186-7_9","article-title":"Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling","volume":"60","author":"A Kowalczyk","year":"2012","journal-title":"Subcell Biochem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"a002915","DOI":"10.1101\/cshperspect.a002915","article-title":"Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling","volume":"2","author":"J Heuberger","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1749-8104-8-7","article-title":"AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development","volume":"8","author":"J Zhang","year":"2013","journal-title":"Neural Dev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ydbio.2011.06.029","article-title":"Phosphorylated beta-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain","volume":"357","author":"D Chilov","year":"2011","journal-title":"Dev Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"H Clevers","year":"2012","journal-title":"Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ceb.2010.07.011","article-title":"Planar cell polarity signaling, cilia and polarized ciliary beating","volume":"22","author":"J Wallingford","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/j.diff.2011.10.007","article-title":"Planar polarity of ependymal cilia","volume":"83","author":"N Kishimoto","year":"2012","journal-title":"Differentiation"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"E3129","DOI":"10.1073\/pnas.1404988111","article-title":"A dual role for planar cell polarity genes in ciliated cells","volume":"111","author":"C Boutin","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.050120","article-title":"Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II","volume":"137","author":"Y Hirota","year":"2010","journal-title":"Development"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.1523\/JNEUROSCI.0686-15.2015","article-title":"Mechanosensory genes Pkd1 and Pkd2 contribute to the planar polarization of brain ventricular epithelium","volume":"35","author":"S Ohata","year":"2015","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1242\/dev.101444","article-title":"The roles and regulation of multicellular rosette structures during morphogenesis","volume":"141","author":"M Harding","year":"2014","journal-title":"Development"},{"key":"ref58","first-page":"e35618","article-title":"Exploring the transcriptome of ciliated cells using in silico dissection of human tissues","volume":"7","author":"A Ivliev","year":"2012","journal-title":"Sergeeva M."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1242\/dev.108209","article-title":"Systematic discovery of novel ciliary genes through functional genomics in the zebrafish","volume":"141","author":"SP Choksi","year":"2014","journal-title":"Development"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/NEN.0000000000000203","article-title":"Cell junction pathology of neural stem cells is associated with ventricular zone disruption, hydrocephalus, and abnormal neurogenesis","volume":"74","author":"M Guerra","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/NEN.0b013e3182a2d5fe","article-title":"Disruption of CDH2\/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls","volume":"72","author":"C Oliver","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e80356","DOI":"10.1371\/journal.pone.0080356","article-title":"Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain","volume":"8","author":"H Yamamoto","year":"2013","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1387\/ijdb.041793ld","article-title":"N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling","volume":"48","author":"L Derycke","year":"2004","journal-title":"Int J Dev Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/ncb1249","article-title":"The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium","volume":"7","author":"J Teng","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e4580","DOI":"10.1371\/journal.pone.0004580","article-title":"Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools","volume":"4","author":"Y Kam","year":"2009","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1101\/gad.1632308","article-title":"PX-RICS mediates ER-to-Golgi transport of the N-cadherin\/beta-catenin complex","volume":"22","author":"T Nakamura","year":"2008","journal-title":"Genes Dev"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ncb2040","article-title":"Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia","volume":"12","author":"B Guirao","year":"2014","journal-title":"Nat Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1039\/C5IB00070J","article-title":"The mechanotransduction machinery at work at adherens junctions","volume":"7","author":"B Ladoux","year":"2015","journal-title":"Integr Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.semcdb.2011.07.023","article-title":"Control of polarized cell morphology and motility by adherens junctions","volume":"22","author":"S Etienne-Manneville","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/19336918.2015.1027478","article-title":"The role of adherens junctions in the developing neocortex","volume":"9","author":"AM Stocker","year":"2015","journal-title":"Cell Adh Migr"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.127.5.1375","article-title":"Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor","volume":"127","author":"H Hoschuetzky","year":"1994","journal-title":"J Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1242\/jcs.027995","article-title":"EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin","volume":"121","author":"A Rappl","year":"2008","journal-title":"J Cell Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1242\/jcs.112.8.1237","article-title":"E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin\/LEF-1-mediated transactivation","volume":"112","author":"S Orsulic","year":"1999","journal-title":"J Cell Sci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"15339","DOI":"10.1073\/pnas.95.26.15339","article-title":"Inhibition of beta-catenin-mediated transactivation by cadherin derivatives","volume":"95","author":"E Sadot","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1038\/srep06940","article-title":"Vangl2 regulates E-cadherin in epithelial cells","volume":"4","author":"T Nagaoka","year":"2014","journal-title":"Sci Rep"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1242\/jcs.048074","article-title":"Vang-like protein 2 and Rac1 interact to regulate adherens junctions","volume":"123","author":"M Lindqvist","year":"2010","journal-title":"J Cell Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:22:54Z","timestamp":1660090974000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184957"}},"subtitle":[],"editor":[{"given":"Anand","family":"Swaroop","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":76,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184957","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]}}}