{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T16:31:02Z","timestamp":1772382662868,"version":"3.50.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Tecnolog\u00eda Agropecuaria (AR)","award":["PNSA 1115052"],"award-info":[{"award-number":["PNSA 1115052"]}]},{"name":"MINECO","award":["AGL2014-52395-C2"],"award-info":[{"award-number":["AGL2014-52395-C2"]}]},{"name":"INTA-INIA","award":["SA 20938"],"award-info":[{"award-number":["SA 20938"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185184","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T17:28:55Z","timestamp":1506446935000},"page":"e0185184","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-8993","authenticated-orcid":true,"given":"Ivana","family":"Soria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Quattrocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Langellotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Gammella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Digiacomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Garcia de la Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Sobrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Zamorano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"ref1","first-page":"449","article-title":"Very fast (and safe) inactivation of foot-and-mouth disease virus and enteroviruses by a combination of binary ethyleneimine and formaldehyde","volume":"119","author":"SJ Barteling","year":"2004","journal-title":"Developments in biologicals"},{"key":"ref2","article-title":"Foot-and-mouth disease vaccines","author":"F Diaz-San Segundo","year":"2016","journal-title":"Vet Microbiol"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1128\/JVI.00401-08","article-title":"Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide","volume":"82","author":"C Cubillos","year":"2008","journal-title":"J Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.antiviral.2016.03.005","article-title":"Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide","volume":"129","author":"E Blanco","year":"2016","journal-title":"Antiviral Res"},{"issue":"5869","key":"ref5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/298030a0","article-title":"Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence","volume":"298","author":"JL Bittle","year":"1982","journal-title":"Nature"},{"issue":"4750","key":"ref6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.3008333","article-title":"Protection of cattle against foot-and-mouth disease by a synthetic peptide","volume":"232","author":"R DiMarchi","year":"1986","journal-title":"Science"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/JVI.71.4.2606-2614.1997","article-title":"A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants","volume":"71","author":"O Taboga","year":"1997","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"475960","DOI":"10.1155\/2013\/475960","article-title":"B epitope multiplicity and B\/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines","volume":"2013","author":"E Blanco","year":"2013","journal-title":"Clin Dev Immunol"},{"issue":"3\u20134","key":"ref9","first-page":"195","article-title":"Peptide dendrimers: applications and synthesis","volume":"90","author":"K Sadler","year":"2002","journal-title":"J Biotechnol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/bc900290d","article-title":"Dendrimers for vaccine and immunostimulatory uses","volume":"21","author":"PM Heegaard","year":"2010","journal-title":"A review. Bioconjugate chemistry"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4049\/jimmunol.146.2.749","article-title":"A T cell epitope in VP1 of foot-and-mouth disease virus is immunodominant for vaccinated cattle","volume":"146","author":"T Collen","year":"1991","journal-title":"J Immunol"},{"issue":"4","key":"ref12","first-page":"594","article-title":"MHC class II restricted recognition of FMDV peptides by bovine T cells","volume":"74","author":"EJ Glass","year":"1991","journal-title":"Immunology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/bc300515t","article-title":"Influence of conjugation chemistry and B epitope orientation on the immune response of branched peptide antigens","volume":"24","author":"M Monso","year":"2013","journal-title":"Bioconjugate chemistry"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1128\/JVI.02879-12","article-title":"Early adaptive immune responses in the respiratory tract of foot-and-mouth disease virus-infected cattle","volume":"87","author":"J Pega","year":"2013","journal-title":"J Virol"},{"issue":"51","key":"ref15","doi-asserted-by":"crossref","first-page":"6577","DOI":"10.1016\/j.vaccine.2008.09.033","article-title":"Updating of the correlation between lpELISA titers and protection from virus challenge for the assessment of the potency of polyvalent aphtovirus vaccines in Argentina","volume":"26","author":"E Maradei","year":"2008","journal-title":"Vaccine"},{"issue":"10","key":"ref16","first-page":"1059","article-title":"The effect of foot-and-mouth disease (FMD) vaccination on virus transmission and the significance for the field","volume":"50","author":"K Orsel","year":"2009","journal-title":"Can Vet J"},{"issue":"41","key":"ref17","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1016\/j.vaccine.2005.05.014","article-title":"Vaccination against foot and mouth disease reduces virus transmission in groups of calves","volume":"23","author":"K Orsel","year":"2005","journal-title":"Vaccine"},{"issue":"7711","key":"ref18","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(71)91748-X","article-title":"Foot-and-mouth virus","volume":"1","author":"RF Sellers","year":"1971","journal-title":"Lancet"},{"key":"ref19","unstructured":"(OIE) WOfAH. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwoieint\/fileadmin\/Home\/eng\/Health_standards\/tahm\/20108_FMDpdf\" xlink:type=\"simple\">http:\/\/wwwoieint\/fileadmin\/Home\/eng\/Health_standards\/tahm\/20108_FMDpdf<\/ext-link>. 2017."},{"issue":"19","key":"ref20","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.vaccine.2014.02.061","article-title":"Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant","volume":"32","author":"V Quattrocchi","year":"2014","journal-title":"Vaccine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2017.00037","article-title":"A DNA Vaccine Formulated with Chemical Adjuvant Provides Partial Protection against Bovine Herpes Virus Infection in Cattle","volume":"8","author":"V Quattrocchi","year":"2017","journal-title":"Frontiers in immunology"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.4049\/jimmunol.166.12.7381","article-title":"Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections","volume":"166","author":"VC Huber","year":"2001","journal-title":"J Immunol"},{"issue":"3\u20134","key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0165-2427(94)05348-V","article-title":"Immortalization and characterization of bovine peritoneal macrophages transfected with SV40 plasmid DNA","volume":"45","author":"JR Stabel","year":"1995","journal-title":"Vet Immunol Immunopathol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1128\/CVI.00034-14","article-title":"Comparison of test methodologies for foot-and-mouth disease virus serotype A vaccine matching","volume":"21","author":"T Tekleghiorghis","year":"2014","journal-title":"Clinical and vaccine immunology: CVI"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1746-6148-10-8","article-title":"Protection induced by a glycoprotein E-deleted bovine herpesvirus type 1 marker strain used either as an inactivated or live attenuated vaccine in cattle","volume":"10","author":"SA Romera","year":"2014","journal-title":"BMC veterinary research"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0264-410X(97)00244-2","article-title":"Induction of anti foot and mouth disease virus T and B cell responses in cattle immunized with a peptide representing ten amino acids of VP1","volume":"16","author":"PI Zamorano","year":"1998","journal-title":"Vaccine"},{"issue":"2","key":"ref27","first-page":"187","article-title":"Opsonization-enhanced phagocytosis of foot-and-mouth disease virus","volume":"65","author":"KC McCullough","year":"1988","journal-title":"Immunology"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.coi.2008.06.005","article-title":"Antibodies against viruses: passive and active immunization","volume":"20","author":"M Law","year":"2008","journal-title":"Current opinion in immunology"},{"issue":"34","key":"ref29","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1016\/j.vaccine.2007.06.010","article-title":"Foot and mouth disease virus transmission among vaccinated pigs after exposure to virus shedding pigs","volume":"25","author":"K Orsel","year":"2007","journal-title":"Vaccine"},{"issue":"25\u201326","key":"ref30","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1016\/S0264-410X(03)00364-5","article-title":"A synthetic peptide containing the consensus sequence of the G-H loop region of foot-and-mouth disease virus type-O VP1 and a promiscuous T-helper epitope induces peptide-specific antibodies but fails to protect cattle against viral challenge","volume":"21","author":"LL Rodriguez","year":"2003","journal-title":"Vaccine"},{"key":"ref31","first-page":"439","article-title":"Handbook of Vertebrate Immunology","author":"P-P Pastoret","year":"1998"},{"issue":"6\u20137","key":"ref32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0264-410X(96)00284-8","article-title":"Total and isotype humoral responses in cattle vaccinated with foot and mouth disease virus (FMDV) immunogen produced either in bovine tongue tissue or in BHK-21 cell suspension cultures","volume":"15","author":"AV Capozzo","year":"1997","journal-title":"Vaccine"},{"issue":"48","key":"ref33","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1016\/j.vaccine.2012.09.011","article-title":"Avidity and subtyping of specific antibodies applied to the indirect assessment of heterologous protection against Foot-and-Mouth Disease Virus in cattle","volume":"30","author":"MA Lavoria","year":"2012","journal-title":"Vaccine"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1128\/JVI.66.4.1835-1840.1992","article-title":"Protective immune response against foot-and-mouth disease","volume":"66","author":"KC McCullough","year":"1992","journal-title":"J Virol"},{"issue":"47\u201348","key":"ref35","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1016\/j.vaccine.2006.04.050","article-title":"Comparative evaluation of six ELISAs for the detection of antibodies to the non-structural proteins of foot-and-mouth disease virus","volume":"24","author":"E Brocchi","year":"2006","journal-title":"Vaccine"},{"issue":"5138","key":"ref36","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.8248784","article-title":"The influence of antigen organization on B cell responsiveness","volume":"262","author":"MF Bachmann","year":"1993","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.immunol.21.120601.141045","article-title":"On natural and artificial vaccinations","volume":"21","author":"RM Zinkernagel","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref38","first-page":"9","article-title":"Foot-and-mouth disease: host range and pathogenesis","volume":"288","author":"S Alexandersen","year":"2005","journal-title":"Current topics in microbiology and immunology"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1471-4906(02)02186-5","article-title":"Stimulation of local antibody production: parenteral or mucosal vaccination?","volume":"23","author":"JP Bouvet","year":"2002","journal-title":"Trends in immunology"},{"issue":"18","key":"ref40","doi-asserted-by":"crossref","first-page":"9581","DOI":"10.1128\/JVI.01082-15","article-title":"Systemic Foot-and-Mouth Disease Vaccination in Cattle Promotes Specific Antibody-Secreting Cells at the Respiratory Tract and Triggers Local Anamnestic Responses upon Aerosol Infection","volume":"89","author":"J Pega","year":"2015","journal-title":"J Virol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/viro.1994.1305","article-title":"Recognition of B and T cell epitopes by cattle immunized with a synthetic peptide containing the major immunogenic site of VP1 FMDV 01 Campos","volume":"201","author":"P Zamorano","year":"1994","journal-title":"Virology"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jviromet.2012.11.011","article-title":"Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity","volume":"187","author":"C Porta","year":"2013","journal-title":"J Virol Methods"},{"issue":"11\u201312","key":"ref43","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0264-410X(01)00483-2","article-title":"Early protection against homologous challenge after a single dose of replication-defective human adenovirus type 5 expressing capsid proteins of foot-and-mouth disease virus (FMDV) strain A24","volume":"20","author":"MP Moraes","year":"2002","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T11:23:02Z","timestamp":1693048982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185184"}},"subtitle":[],"editor":[{"given":"Paulo Lee","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,26]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185184","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,26]]}}}