{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:26:35Z","timestamp":1748327195278},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185348","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T18:27:53Z","timestamp":1510684073000},"page":"e0185348","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ten year experience with antiretroviral treatment in Cambodia: Trends in patient characteristics and treatment outcomes"],"prefix":"10.1371","volume":"12","author":[{"given":"Phirum","family":"Lay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sokkab","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunpiseth","family":"Soeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pich Sovannary","family":"Srey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopheak","family":"Thai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutgarde","family":"Lynen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan van","family":"Griensven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"ref1","unstructured":"UNAIDS. UNAIDS Report on the global AIDS epidemic. 2016."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(10)60666-6","article-title":"Prognosis of patients with HIV-1 infection starting antiretroviral therapy in sub-Saharan Africa: a collaborative analysis of scale-up programmes","volume":"376","author":"M May","year":"2010","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cid\/cit724","article-title":"Advanced HIV Disease at Entry into HIV Care and Initiation of Antiretroviral Therapy During 2006\u20132011: Findings From Four Sub-Saharan African Countries","volume":"58","author":"M Lahuerta","year":"2014","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref4","unstructured":"WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. 2013."},{"key":"ref5","unstructured":"WHO. Antiretroviral therapy for HIV infection in adults and adolescents. Recommendations for a public health approach: 2010 revision 2010."},{"key":"ref6","unstructured":"WHO. Antiretroviral therapy for HIV infection in adults and adolescents. Recommendations for a public health approach (2006 revision) 2006."},{"key":"ref7","unstructured":"WHO. Scaling up antiretroviral therapy in resource limited settings: treatment guidelines for a public health approach; 2003 revision. 2003."},{"key":"ref8","unstructured":"WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach\u2014Second edition 2016."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/QAD.0b013e328333bfb7","article-title":"Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa","volume":"24","author":"A Boulle","year":"2010","journal-title":"AIDS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/QAI.0b013e3181ff0bdc","article-title":"Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa","volume":"56","author":"MD Nglazi","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1016\/S2214-109X(13)70149-9","article-title":"Outcomes of the Botswana national HIV\/AIDS treatment programme from 2002 to 2010: a longitudinal analysis","volume":"2","author":"M Farahani","year":"2014","journal-title":"Lancet Glob Health"},{"key":"ref12","unstructured":"Authority TNA. Cambodia Country Progress Report. Reporting Period: January-December 2014 2015."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2471\/BLT.12.111153","article-title":"Timing of antiretroviral therapy in Cambodian hospital after diagnosis of tuberculosis: impact of revised WHO guidelines","volume":"91","author":"K Choun","year":"2013","journal-title":"Bulletin of the World Health Organization"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e30647","DOI":"10.1371\/journal.pone.0030647","article-title":"Incidence of treatment-limiting toxicity with stavudine-based antiretroviral therapy in Cambodia: a retrospective cohort study","volume":"7","author":"V Phan","year":"2012","journal-title":"PloS one"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1365-3156.2009.02334.x","article-title":"Five-year experience with scaling-up access to antiretroviral treatment in an HIV care programme in Cambodia","volume":"14","author":"S Thai","year":"2009","journal-title":"Tropical medicine & international health: TM & IH"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e88552","DOI":"10.1371\/journal.pone.0088552","article-title":"Hepatitis B and C co-infection among HIV-infected adults while on antiretroviral treatment: long-term survival, CD4 cell count recovery and antiretroviral toxicity in Cambodia","volume":"9","author":"J van Griensven","year":"2014","journal-title":"PloS one"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.trstmh.2011.08.007","article-title":"Predictors of immune recovery and the association with late mortality while on antiretroviral treatment in Cambodia","volume":"105","author":"J van Griensven","year":"2011","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/QAI.0b013e3181af6705","article-title":"An algorithm to optimize viral load testing in HIV-positive patients with suspected first-line antiretroviral therapy failure in Cambodia","volume":"52","author":"L Lynen","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/QAI.0b013e318285d28c","article-title":"Validation of a clinical prediction score to target viral load testing in adults with suspected first-line treatment failure in resource-constrained settings","volume":"62","author":"V Phan","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref20","first-page":"6","article-title":"Integrated Cryptococcal Antigen Screening and Pre-Emptive Treatment Prior to Initiation of Antiretroviral Treatment in Cambodia","volume":"4","author":"B PS Chim","year":"2013","journal-title":"Journal of AIDS & clinical research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1097\/QAD.0b013e32828cc8b7","article-title":"Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia","volume":"21","author":"L Ferradini","year":"2007","journal-title":"AIDS"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/QAD.0b013e328012c54f","article-title":"Response to highly active antiretroviral therapy among severely immuno-compromised HIV-infected patients in Cambodia","volume":"21","author":"Y Madec","year":"2007","journal-title":"AIDS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-3156.2010.02689.x","article-title":"Immunovirological outcomes and resistance patterns at 4 years of antiretroviral therapy use in HIV-infected patients in Cambodia","volume":"16","author":"M Pujades-Rodriguez","year":"2011","journal-title":"Tropical medicine & international health: TM & IH"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/QAI.0b013e3181967602","article-title":"National expansion of antiretroviral treatment in Thailand, 2000\u20132007: program scale-up and patient outcomes","volume":"50","author":"S Chasombat","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1468-1293.2007.00417.x","article-title":"Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database","volume":"8","author":"J Zhou","year":"2007","journal-title":"HIV medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/apc.2012.0439","article-title":"Antiretroviral treatment interruption and loss to follow-up in two HIV cohorts in Australia and Asia: implications for 'test and treat' prevention strategy","volume":"27","author":"R Guy","year":"2013","journal-title":"AIDS patient care and STDs"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e0143320","DOI":"10.1371\/journal.pone.0143320","article-title":"Advanced HIV Disease at Enrolment in HIV Care: Trends and Associated Factors over a Ten Year Period in Cambodia","volume":"10","author":"R Pe","year":"2015","journal-title":"PloS one"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1097\/QAI.0000000000000268","article-title":"Outcomes of antiretroviral therapy over a 10-year period of expansion: a multicohort analysis of African and Asian HIV programs","volume":"67","author":"A Grimsrud","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1001494","DOI":"10.1371\/journal.pmed.1001494","article-title":"Switching HIV treatment in adults based on CD4 count versus viral load monitoring: a randomized, non-inferiority trial in Thailand","volume":"10","author":"G Jourdain","year":"2013","journal-title":"PLoS medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e68995","DOI":"10.1371\/journal.pone.0068995","article-title":"Outcomes for efavirenz versus nevirapine-containing regimens for treatment of HIV-1 infection: a systematic review and meta-analysis","volume":"8","author":"P Pillay","year":"2013","journal-title":"PloS one"},{"key":"ref31","first-page":"42","article-title":"Risk factors associated with virologic failure in HIV- infected patients receiving antiretroviral therapy at a public hospital in Peru","volume":"30","author":"J Alave","year":"2013","journal-title":"Revista chilena de infectologia: organo oficial de la Sociedad Chilena de Infectologia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1001167","DOI":"10.1371\/journal.pmed.1001167","article-title":"Engaging men in prevention and care for HIV\/AIDS in Africa","volume":"9","author":"EJ Mills","year":"2012","journal-title":"PLoS medicine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/09540120903111536","article-title":""No one can ask me 'Why do you take that stuff?'": men's experiences of antiretroviral treatment in South Africa","volume":"22","author":"M Fitzgerald","year":"2010","journal-title":"AIDS care"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1758-2652-14-52","article-title":"Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda","volume":"14","author":"EJ Mills","year":"2011","journal-title":"Journal of the International AIDS Society"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/aid.2013.0208","article-title":"Sex differences in HIV outcomes in the highly active antiretroviral therapy era: a systematic review","volume":"30","author":"JL Castilho","year":"2014","journal-title":"AIDS research and human retroviruses"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:47:48Z","timestamp":1540298868000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185348"}},"subtitle":[],"editor":[{"given":"Dimitrios","family":"Paraskevis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185348","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,14]]}}}