{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:42:20Z","timestamp":1787766140583,"version":"build-2784847793"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Labor and Welfare Japan","award":["H20-Hepatitis-general-008"],"award-info":[{"award-number":["H20-Hepatitis-general-008"]}]},{"name":"Core Research for Evolutional Science and Technology (JP)"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185490","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:31:20Z","timestamp":1517423480000},"page":"e0185490","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":125,"title":["Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-7404","authenticated-orcid":true,"given":"Takahisa","family":"Kawaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Mitsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kanbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohichiro","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Tokushige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendo","family":"Kiyosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Uto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuji","family":"Komorizono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Kawanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Okanoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"CA Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"ZM Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jhep.2014.11.034","article-title":"Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management","volume":"62","author":"S McPherson","year":"2015","journal-title":"J Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","article-title":"Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma","volume":"123","author":"E Bugianesi","year":"2002","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study","volume":"129","author":"LA Adams","year":"2005","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhep.2014.02.030","article-title":"Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"61","author":"Y-L Liu","year":"2014","journal-title":"J Hepatol"},{"key":"ref7","first-page":"428","article-title":"Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma","volume":"9","author":"K Yasui","year":"2011","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/hep.24268","article-title":"Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality","volume":"53","author":"ZM Younossi","year":"2011","journal-title":"Hepatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease","volume":"149","author":"P Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"S Romeo","year":"2008","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/hep.24283","article-title":"Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease","volume":"53","author":"S Sookoian","year":"2011","journal-title":"Hepatol Baltim Md"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1001324","DOI":"10.1371\/journal.pgen.1001324","article-title":"Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits","volume":"7","author":"EK Speliotes","year":"2011","journal-title":"PLoS Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00439-012-1141-y","article-title":"A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease","volume":"131","author":"SM Zain","year":"2012","journal-title":"Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.jhep.2012.01.007","article-title":"IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease","volume":"56","author":"S Petta","year":"2012","journal-title":"J Hepatol"},{"key":"ref15","article-title":"PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease","author":"L Valenti","year":"2013","journal-title":"Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00535-015-1116-6","article-title":"The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus","volume":"51","author":"M Ueyama","year":"2015","journal-title":"J Gastroenterol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","author":"J Kozlitina","year":"2014","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.27556","article-title":"Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity","volume":"61","author":"S Sookoian","year":"2015","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"S Buch","year":"2015","journal-title":"Nat Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent","volume":"150","author":"RM Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e38322","DOI":"10.1371\/journal.pone.0038322","article-title":"Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese","volume":"7","author":"T Kawaguchi","year":"2012","journal-title":"PloS One"},{"key":"ref22","article-title":"Human genetic variation database, a reference database of genetic variations in the Japanese population","author":"K Higasa","year":"2016","journal-title":"J Hum Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A Tool for Genome-wide Complex Trait Analysis","volume":"88","author":"J Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.genom.9.081307.164242","article-title":"Genotype imputation","volume":"10","author":"Y Li","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"T Consortium","year":"2012","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1053\/j.gastro.2016.01.037","article-title":"Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease","volume":"150","author":"QM Anstee","year":"2016","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"E1126","DOI":"10.1210\/jc.2010-2017","article-title":"Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans","volume":"96","author":"A Peter","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/hep.24793","article-title":"Glucokinase links Kr\u00fcppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease","volume":"55","author":"LP Bechmann","year":"2012","journal-title":"Hepatol Baltim Md"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","article-title":"Mapping the Genetic Architecture of Gene Expression in Human Liver","volume":"6","author":"EE Schadt","year":"2008","journal-title":"PLOS Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s11033-010-0212-1","article-title":"Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people","volume":"38","author":"Z Yang","year":"2010","journal-title":"Mol Biol Rep"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1101\/gr.092189.109","article-title":"Genome-wide comparisons of variation in linkage disequilibrium","volume":"19","author":"YY Teo","year":"2009","journal-title":"Genome Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T21:45:07Z","timestamp":1719783907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185490"}},"subtitle":[],"editor":[{"given":"Silvia C.","family":"Sookoian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185490","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}