{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:54:58Z","timestamp":1773388498711,"version":"3.50.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/26983-3"],"award-info":[{"award-number":["2014\/26983-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/24596-2"],"award-info":[{"award-number":["2014\/24596-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185559","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T17:46:04Z","timestamp":1506534364000},"page":"e0185559","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["High prevalence of HIV-1 transmitted drug-resistance mutations from proviral DNA massively parallel sequencing data of therapy-na\u00efve chronically infected Brazilian blood donors"],"prefix":"10.1371","volume":"12","author":[{"given":"Rodrigo","family":"Pess\u00f4a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-8262","authenticated-orcid":true,"given":"Sabri S.","family":"Sanabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"ref1"},{"key":"ref2","unstructured":"Division of HIV\/AIDS Epidemiology and Surveillance, National HIV and Retrovirology Laboratories, Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Health Canada: HIV-1 strain and primary drug resistance in Canada (2006) Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.phacaspc.gc.ca\/publicat\/hiv1-vih1\/pdf\/hiv-1-strain-01-e.pdf\" xlink:type=\"simple\">http:\/\/www.phacaspc.gc.ca\/publicat\/hiv1-vih1\/pdf\/hiv-1-strain-01-e.pdf<\/ext-link>. Assessed 25 September 2012."},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/jac\/dkm082","article-title":"Prevalence and determinants of transmitted antiretroviral drug resistance in HIV-1 infection","volume":"59","author":"CL Booth","year":"2007","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1056\/NEJMoa013552","article-title":"Antiretroviral-drug resistance among patients recently infected with HIV","volume":"347","author":"SJ Little","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"ref5","first-page":"17","article-title":"Temporal changes in the epidemiology of transmission of drug-resistant HIV-1 across the world","volume":"14","author":"D Frentz","year":"2012","journal-title":"AIDS Rev"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/135965350400900514","article-title":"Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe","volume":"9","author":"D Pillay","year":"2004","journal-title":"Antivir Ther"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1097\/QAD.0b013e3283388742","article-title":"Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.-2006","volume":"24","author":"WH Wheeler","year":"2010","journal-title":"AIDS"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/QAI.0b013e3182618f05","article-title":"Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients","volume":"61","author":"EL Yanik","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1086\/427212","article-title":"Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy","volume":"40","author":"RM Novak","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"ref10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/hiv.12236","article-title":"Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial","volume":"16","author":"JD Baxter","year":"2015","journal-title":"HIV Med"},{"issue":"1","key":"ref11","first-page":"3","article-title":"Update on HIV-1 acquired and transmitted drug resistance in Africa","volume":"17","author":"D Ssemwanga","year":"2015","journal-title":"AIDS Rev"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/QAD.0b013e3283367796","article-title":"High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors","volume":"24","author":"C Charpentier","year":"2010","journal-title":"AIDS"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jcv.2010.10.001","article-title":"Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naive patients","volume":"50","author":"KJ Metzner","year":"2011","journal-title":"J Clin Virol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/JCM.37.7.2291-2296.1999","article-title":"Worldwide evaluation of DNA sequencing approaches for identification of drug resistance mutations in the human immunodeficiency virus type 1 reverse transcriptase","volume":"37","author":"R Schuurman","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"13","key":"ref15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/jama.2011.375","article-title":"Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis","volume":"305","author":"JZ Li","year":"2011","journal-title":"JAMA"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1086\/596736","article-title":"Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes","volume":"199","author":"BB Simen","year":"2009","journal-title":"J Infect Dis"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/JVI.06541-11","article-title":"Deep sequencing reveals minor protease resistance mutations in patients failing a protease inhibitor regimen","volume":"86","author":"R Fisher","year":"2012","journal-title":"J Virol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"e36494","DOI":"10.1371\/journal.pone.0036494","article-title":"Low-cost ultra-wide genotyping using Roche\/454 pyrosequencing for surveillance of HIV drug resistance","volume":"7","author":"DM Dudley","year":"2012","journal-title":"PLoS One"},{"issue":"22","key":"ref19","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1128\/JVI.01378-10","article-title":"Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing","volume":"84","author":"BN Bimber","year":"2010","journal-title":"J Virol"},{"issue":"22","key":"ref20","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.1105688108","article-title":"Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine","volume":"108","author":"VF Boltz","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.antiviral.2009.09.015","article-title":"Clinical management of HIV-1 resistance","volume":"85","author":"R Paredes","year":"2010","journal-title":"Antiviral Res"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/trf.12936","article-title":"Enhanced detection of viral diversity using partial and near full-length genomes of human immunodeficiency virus Type 1 provirus deep sequencing data from recently infected donors at four blood centers in Brazil","volume":"55","author":"R Pessoa","year":"2015","journal-title":"Transfusion"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"e112674","DOI":"10.1371\/journal.pone.0112674","article-title":"Deep sequencing of HIV-1 near full-length proviral genomes identifies high rates of BF1 recombinants including two novel circulating recombinant forms (CRF) 70_BF1 and a disseminating 71_BF1 among blood donors in Pernambuco, Brazil","volume":"9","author":"R Pessoa","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"e1002529","DOI":"10.1371\/journal.ppat.1002529","article-title":"Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection","volume":"8","author":"MR Henn","year":"2012","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tibtech.2012.05.005","article-title":"Next generation deep sequencing and vaccine design: today and tomorrow","volume":"30","author":"F Luciani","year":"2012","journal-title":"Trends Biotechnol"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1101\/gr.6468307","article-title":"Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistance","volume":"17","author":"C Wang","year":"2007","journal-title":"Genome Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-genom-091212-153406","article-title":"Deep sequencing of HIV: clinical and research applications","volume":"15","author":"SB Chabria","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/JCM.42.1.426-430.2004","article-title":"Prevalence of human immunodeficiency virus drug resistance mutations and subtypes in drug-naive, infected individuals in the army health service of Rio de Janeiro, Brazil","volume":"42","author":"IL Pires","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1128\/AAC.43.7.1674","article-title":"Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals","volume":"43","author":"R Brindeiro","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00002030-200301030-00004","article-title":"A specific subtype C of human immunodeficiency virus type 1 circulates in Brazil","volume":"17","author":"MA Soares","year":"2003","journal-title":"AIDS"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/01.qai.0000199097.88344.50","article-title":"Trends in antiretroviral drug resistance and clade distributions among HIV-1\u2014infected blood donors in Sao Paulo, Brazil","volume":"41","author":"CC Barreto","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4172\/2155-6113.1000141","article-title":"Comparing Peripheral Blood Mononuclear Cell DNA and Circulating Plasma viral RNA pol Genotypes of Subtype C HIV-1","volume":"3","author":"L Banks","year":"2012","journal-title":"J AIDS Clin Res"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"e0152499","DOI":"10.1371\/journal.pone.0152499","article-title":"Ultra-Deep Sequencing of HIV-1 near Full-Length and Partial Proviral Genomes Reveals High Genetic Diversity among Brazilian Blood Donors","volume":"11","author":"R Pessoa","year":"2016","journal-title":"PLoS One"},{"key":"ref34","unstructured":"Zenodo repository browser <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.5281\/zenodo.46793\" xlink:type=\"simple\">https:\/\/doi.org\/10.5281\/zenodo.46793<\/ext-link><\/comment>"},{"issue":"3","key":"ref35","first-page":"642","article-title":"2014 Update of the drug resistance mutations in HIV-1","volume":"22","author":"AM Wensing","year":"2014","journal-title":"Top Antivir Med"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"e4724","DOI":"10.1371\/journal.pone.0004724","article-title":"Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update","volume":"4","author":"DE Bennett","year":"2009","journal-title":"PLoS One"},{"issue":"2","key":"ref37","first-page":"67","article-title":"HIV-1 drug resistance mutations: an updated framework for the second decade of HAART","volume":"10","author":"RW Shafer","year":"2008","journal-title":"AIDS Rev"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"E523","DOI":"10.1111\/1469-0691.12264","article-title":"Transmitted drug-resistance in human immunodeficiency virus-infected adult population in El Salvador, Central America","volume":"19","author":"A Holguin","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1016\/j.ijid.2009.05.006","article-title":"Antiretroviral drug resistance in HIV-infected patients in Colombia","volume":"14","author":"CA DiazGranados","year":"2010","journal-title":"Int J Infect Dis"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"e27812","DOI":"10.1371\/journal.pone.0027812","article-title":"National prevalence and trends of HIV transmitted drug resistance in Mexico","volume":"6","author":"S Avila-Rios","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jcv.2010.03.013","article-title":"Transmitted drug resistance and type of infection in newly diagnosed HIV-1 individuals in Honduras","volume":"49","author":"W Murillo","year":"2010","journal-title":"J Clin Virol"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S1020-49892011001200024","article-title":"Prevalence and patterns of HIV transmitted drug resistance in Guatemala","volume":"30","author":"S Avila-Rios","year":"2011","journal-title":"Rev Panam Salud Publica"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/aid.2014.0057","article-title":"HIV-1 drug resistance surveillance in antiretroviral treatment-naive individuals from a reference hospital in Guatemala, 2010\u20132013","volume":"31","author":"S Avila-Rios","year":"2015","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S1473-3099(11)70149-9","article-title":"HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study","volume":"11","author":"RL Hamers","year":"2011","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"ref45","doi-asserted-by":"crossref","first-page":"e42996","DOI":"10.1371\/journal.pone.0042996","article-title":"HIV-1 genetic diversity and transmitted drug resistance mutations among patients from the North, Central and South regions of Angola","volume":"7","author":"JM Afonso","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/jac\/dkv500","article-title":"Sharp increase in rates of HIV transmitted drug resistance at antenatal clinics in Botswana demonstrates the need for routine surveillance","volume":"71","author":"CF Rowley","year":"2016","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"e23091","DOI":"10.1371\/journal.pone.0023091","article-title":"HIV drug resistance (HIVDR) in antiretroviral therapy-naive patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high","volume":"6","author":"C Kasang","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1473-3099(11)70032-9","article-title":"Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study","volume":"11","author":"L Wittkop","year":"2011","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1093\/jac\/dkv120","article-title":"Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999\u20132011","volume":"70","author":"K Buchacz","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"e25281","DOI":"10.1371\/journal.pone.0025281","article-title":"Sentinel surveillance of HIV-1 transmitted drug resistance, acute infection and recent infection","volume":"6","author":"HM Truong","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/aid.2011.0333","article-title":"Moderate prevalence of transmitted drug resistance mutations among antiretroviral-naive HIV-infected pregnant women in Rio de Janeiro, Brazil","volume":"29","author":"JH Pilotto","year":"2013","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00042560-199910010-00001","article-title":"Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations","volume":"22","author":"K Van Laethem","year":"1999","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/aid.1998.14.869","article-title":"Comparative performance of high-density oligonucleotide sequencing and dideoxynucleotide sequencing of HIV type 1 pol from clinical samples","volume":"14","author":"HF Gunthard","year":"1998","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/AAC.02710-13","article-title":"Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism","volume":"58","author":"RM Gibson","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12977-014-0122-8","article-title":"Cross-clade simultaneous HIV drug resistance genotyping for reverse transcriptase, protease, and integrase inhibitor mutations by Illumina MiSeq","volume":"11","author":"DM Dudley","year":"2014","journal-title":"Retrovirology"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JVI.01960-08","article-title":"Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals","volume":"83","author":"M Kearney","year":"2009","journal-title":"J Virol"},{"issue":"10","key":"ref57","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1086\/379215","article-title":"Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions","volume":"188","author":"KJ Metzner","year":"2003","journal-title":"J Infect Dis"},{"issue":"8","key":"ref58","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1468-1293.2009.00814.x","article-title":"HIV-1 proviral resistance mutations: usefulness in clinical practice","volume":"11","author":"B Kabamba-Mukadi","year":"2010","journal-title":"HIV Med"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jcv.2006.12.018","article-title":"Genotypic resistance in plasma and peripheral blood lymphocytes in a group of naive HIV-1 patients","volume":"38","author":"I Bon","year":"2007","journal-title":"J Clin Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2334-13-52","article-title":"Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing","volume":"13","author":"V Bansode","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1086\/650001","article-title":"Transmission of HIV-1 drug-resistant variants: prevalence and effect on treatment outcome","volume":"50","author":"MR Jakobsen","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/jac\/dki038","article-title":"The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance","volume":"55","author":"A Noe","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/AAC.01795-09","article-title":"The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity","volume":"54","author":"HT Xu","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/jac\/dkt316","article-title":"Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing","volume":"69","author":"GL Melikian","year":"2014","journal-title":"J Antimicrob Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:17:48Z","timestamp":1719479868000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185559"}},"subtitle":[],"editor":[{"given":"Dimitrios","family":"Paraskevis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":64,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185559","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}