{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:48:32Z","timestamp":1793062112743,"version":"4.5.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR000457-06"],"award-info":[{"award-number":["UL1 TR000457-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004863","name":"New York State Foundation for Science, Technology and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1650441"],"award-info":[{"award-number":["DGE-1650441"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185716","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T13:33:55Z","timestamp":1508506435000},"page":"e0185716","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Total disc replacement using tissue-engineered intervertebral discs in the canine cervical spine"],"prefix":"10.1371","volume":"12","author":[{"given":"Yu","family":"Moriguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mojica-Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Grunert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenton","family":"Pennicooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamina","family":"Khair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Navarro-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo J.","family":"Ricart Arbona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"H\u00e4rtl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-6433","authenticated-orcid":true,"given":"Lawrence J.","family":"Bonassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"issue":"9178","key":"ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(99)01312-4","article-title":"Epidemiological features of chronic low-back pain","volume":"354","author":"GB Andersson","year":"1999","journal-title":"Lancet"},{"key":"ref2","first-page":"279","article-title":"Nonsurgical management of low back pain and lumbar disk degeneration","volume":"54","author":"DS Brodke","year":"2005","journal-title":"Instr Course Lect"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/BRS.0b013e31820cccfb","article-title":"Spinal fusion in the United States: analysis of trends from 1998 to 2008","volume":"37","author":"SS Rajaee","year":"2012","journal-title":"Spine"},{"key":"ref4","first-page":"20","article-title":"Adjacent-level degeneration after cervical disc arthroplasty versus fusion","volume":"3","author":"CV Maldonado","year":"2011","journal-title":"Eur Spine J"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00701-009-0217-5","article-title":"Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages","volume":"151","author":"T Sugawara","year":"2009","journal-title":"Acta Neurochir (Wien)"},{"issue":"15","key":"ref6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1097\/BRS.0b013e3181ec5c7d","article-title":"Adjacent segment motion after anterior cervical discectomy and fusion versus Prodisc-c cervical total disk arthroplasty: analysis from a randomized, controlled trial","volume":"36","author":"MP Kelly","year":"2011","journal-title":"Spine"},{"issue":"9566","key":"ref7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(07)60496-6","article-title":"Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study","volume":"369","author":"D Ruan","year":"2007","journal-title":"Lancet"},{"issue":"5110","key":"ref8","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue engineering","volume":"260","author":"R Langer","year":"1993","journal-title":"Science"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/01.BRS.0000128264.46510.27","article-title":"Tissue-engineered composites of anulus fibrosus and nucleus pulposus for intervertebral disc replacement","volume":"29","author":"H Mizuno","year":"2004","journal-title":"Spine"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biomaterials.2005.06.042","article-title":"Biomechanical and biochemical characterization of composite tissue-engineered intervertebral discs","volume":"27","author":"H Mizuno","year":"2006","journal-title":"Biomaterials"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbrc.2011.03.015","article-title":"Construction of tissue-engineered composite intervertebral disc and preliminary morphological and biochemical evaluation","volume":"407","author":"Y Zhuang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.actbio.2014.02.024","article-title":"Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model","volume":"10","author":"JT Martin","year":"2014","journal-title":"Acta Biomater"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.biomaterials.2005.07.007","article-title":"Formation of a nucleus pulposus-cartilage endplate construct in vitro","volume":"27","author":"DJ Hamilton","year":"2006","journal-title":"Biomaterials"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1089\/ten.tea.2009.0442","article-title":"Self-assembly of aligned tissue-engineered annulus fibrosus and intervertebral disc composite via collagen gel contraction","volume":"16","author":"RD Bowles","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/nbm.1651","article-title":"Image-based tissue engineering of a total intervertebral disc implant for restoration of function to the rat lumbar spine","volume":"25","author":"RD Bowles","year":"2012","journal-title":"NMR Biomed"},{"issue":"32","key":"ref16","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1073\/pnas.1107094108","article-title":"Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine","volume":"108","author":"RD Bowles","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0028-1100918","article-title":"Total disc replacement using a tissue-engineered intervertebral disc in vivo: new animal model and initial results","volume":"1","author":"H Gebhard","year":"2010","journal-title":"Evid Based Spine Care J"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0030-1267084","article-title":"Biological intervertebral disc replacement: an in vivo model and comparison of two surgical techniques to approach the rat caudal disc","volume":"2","author":"H Gebhard","year":"2011","journal-title":"Evid Based Spine Care J"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3171\/2013.12.SPINE13112","article-title":"Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine","volume":"20","author":"P Grunert","year":"2014","journal-title":"J Neurosurg Spine"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0031-1274758","article-title":"Tissue-engineered total disc replacement: final outcomes of a murine caudal disc in vivo study","volume":"2","author":"AR James","year":"2011","journal-title":"Evid Based Spine Care J"},{"issue":"23","key":"ref21","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1097\/01.brs.0000146498.04628.f9","article-title":"Animal models of intervertebral disc degeneration: lessons learned","volume":"29","author":"JC Lotz","year":"2004","journal-title":"Spine"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/01.brs.0000253961.40910.c1","article-title":"Comparison of animals used in disc research to human lumbar disc geometry","volume":"32","author":"GD O'Connell","year":"2007","journal-title":"Spine"},{"issue":"15","key":"ref23","doi-asserted-by":"crossref","first-page":"E900","DOI":"10.1097\/BRS.0b013e31824d911c","article-title":"Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen content","volume":"37","author":"BL Showalter","year":"2012","journal-title":"Spine"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"E369","DOI":"10.1097\/BRS.0000000000000194","article-title":"Assessment of intervertebral disc degeneration based on quantitative magnetic resonance imaging analysis: an in vivo study","volume":"39","author":"P Grunert","year":"2014","journal-title":"Spine"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/BRS.0b013e3181d74414","article-title":"Engineered disc-like angle-ply structures for intervertebral disc replacement","volume":"35","author":"NL Nerurkar","year":"2010","journal-title":"Spine"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1089\/ten.tea.2008.0215","article-title":"Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam","volume":"14","author":"LJ Nesti","year":"2008","journal-title":"Tissue Eng Part A"},{"issue":"14","key":"ref27","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/BRS.0b013e3181788760","article-title":"Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration","volume":"33","author":"A Abbushi","year":"2008","journal-title":"Spine"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1097\/BRS.0b013e3181dce34c","article-title":"Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration","volume":"36","author":"M Bendtsen","year":"2011","journal-title":"Spine"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1007\/s00586-012-2443-4","article-title":"Intervertebral disc cell- and hydrogel-supported and spontaneous intervertebral disc repair in nucleotomized sheep","volume":"21","author":"K Benz","year":"2012","journal-title":"Eur Spine J"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.biomaterials.2013.10.056","article-title":"Effects of bound versus soluble pentosan polysulphate in PEG\/HA-based hydrogels tailored for intervertebral disc regeneration","volume":"35","author":"JE Frith","year":"2014","journal-title":"Biomaterials"},{"issue":"21","key":"ref31","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1097\/BRS.0b013e3181a54157","article-title":"Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model","volume":"34","author":"T Ganey","year":"2009","journal-title":"Spine"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3171\/2012.1.SPINE11852","article-title":"Immunoselected STRO-3+ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs","volume":"16","author":"P Ghosh","year":"2012","journal-title":"J Neurosurg Spine"},{"issue":"26","key":"ref33","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1097\/BRS.0b013e318209fd85","article-title":"Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II\/hyaluronan\/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model","volume":"36","author":"B Huang","year":"2011","journal-title":"Spine"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1097\/01.brs.0000217687.36874.c4","article-title":"Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration","volume":"31","author":"T Iwashina","year":"2006","journal-title":"Spine"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/stem.1717","article-title":"Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair","volume":"32","author":"VY Leung","year":"2014","journal-title":"Stem Cells"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10856-009-3871-5","article-title":"Construction of collagen II\/hyaluronate\/chondroitin-6-sulfate tri-copolymer scaffold for nucleus pulposus tissue engineering and preliminary analysis of its physico-chemical properties and biocompatibility","volume":"21","author":"CQ Li","year":"2010","journal-title":"J Mater Sci Mater Med"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s00586-014-3314-y","article-title":"Short-term follow-up of disc cell therapy in a porcine nucleotomy model with an albumin-hyaluronan hydrogel: in vivo and in vitro results of metabolic disc cell activity and implant distribution","volume":"23","author":"GW Omlor","year":"2014","journal-title":"Eur Spine J"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10856-006-0693-6","article-title":"Tissue engineered intervertebral disc repair in the pig using injectable polymers","volume":"18","author":"PA Revell","year":"2007","journal-title":"J Mater Sci Mater Med"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1089\/ten.tea.2009.0770","article-title":"Experimental intervertebral disc regeneration with tissue-engineered composite in a canine model","volume":"16","author":"DK Ruan","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.spinee.2010.06.019","article-title":"Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta1 decrease rabbit intervertebral disc degeneration","volume":"10","author":"H Yang","year":"2010","journal-title":"Spine J"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2010.3.FOCUS1050","article-title":"Cervical motion preservation using mesenchymal progenitor cells and pentosan polysulfate, a novel chondrogenic agent: preliminary study in an ovine model","volume":"28","author":"T Goldschlager","year":"2010","journal-title":"Neurosurg Focus"},{"issue":"1\u20132","key":"ref42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/ten.tea.2012.0255","article-title":"Tissue-engineered allograft intervertebral disc transplantation for the treatment of degenerative disc disease: experimental study in a beagle model","volume":"19","author":"H Xin","year":"2013","journal-title":"Tissue Eng Part A"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/0021-9290(94)90279-8","article-title":"Stress analysis of a canine spinal motion segment using the finite element technique","volume":"27","author":"TH Lim","year":"1994","journal-title":"J Biomech"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s005860100346","article-title":"The use of a quadruped as an in vivo model for the study of the spine\u2014biomechanical considerations","volume":"11","author":"TH Smit","year":"2002","journal-title":"Eur Spine J"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/BRS.0b013e31821e5665","article-title":"The dog as an animal model for intervertebral disc degeneration?","volume":"37","author":"N Bergknut","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jor.1100030304","article-title":"Effects of spinal fusion on the proteoglycans of the canine intervertebral disc","volume":"3","author":"TC Cole","year":"1985","journal-title":"J Orthop Res"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1292\/jvms.70.37","article-title":"Enhanced type X collagen expression in the extruded nucleus pulposus of the chondrodystrophoid dog","volume":"70","author":"H Itoh","year":"2008","journal-title":"J Vet Med Sci"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1532-950X.2010.00780.x","article-title":"Microfenestration using the CUSA Excel ultrasonic aspiration system in chondrodystrophic dogs with thoracolumbar disk extrusion: a descriptive cadaveric and clinical study","volume":"40","author":"F Forterre","year":"2011","journal-title":"Vet Surg"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.0021-8782.2004.00352.x","article-title":"Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison","volume":"205","author":"CJ Hunter","year":"2004","journal-title":"J Anat"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1302\/0301-620X.89B6.18806","article-title":"Survival and clinical outcome of SB Charite III disc replacement for back pain","volume":"89","author":"R Ross","year":"2007","journal-title":"The Journal of bone and joint surgery British volume"},{"issue":"24","key":"ref51","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1097\/00007632-200112150-00012","article-title":"Mechanical properties of the human cervical spine as shown by three-dimensional load-displacement curves","volume":"26","author":"MM Panjabi","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jocn.2015.01.021","article-title":"Posterior longitudinal ligament resection or preservation in anterior cervical decompression surgery","volume":"22","author":"MJ Avila","year":"2015","journal-title":"J Clin Neurosci"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrrheum.2014.91","article-title":"Intervertebral disc regeneration: do nutrients lead the way?","volume":"10","author":"YC Huang","year":"2014","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1302\/0301-620X.92B5.23015","article-title":"Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc","volume":"92","author":"HT Hee","year":"2010","journal-title":"The Journal of bone and joint surgery British volume"},{"issue":"15","key":"ref55","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1097\/01.brs.0000224558.81765.56","article-title":"Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis","volume":"31","author":"T Guehring","year":"2006","journal-title":"Spine"},{"issue":"9","key":"ref56","doi-asserted-by":"crossref","first-page":"E550","DOI":"10.1097\/BRS.0000000000000269","article-title":"Spinal traction promotes molecular transportation in a simulated degenerative intervertebral disc model","volume":"39","author":"YW Kuo","year":"2014","journal-title":"Spine"},{"key":"ref57","article-title":"Systemic Delivery of Bone Marrow Mesenchymal Stem Cells for In Situ Intervertebral Disc Regeneration","author":"C Cunha","year":"2016","journal-title":"Stem Cells Transl Med"},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/PHM.0000000000000194","article-title":"Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo","volume":"94","author":"Y Zhang","year":"2015","journal-title":"Am J Phys Med Rehabil"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1097\/BRS.0b013e318232909d","article-title":"The effect of remodeling on the kinematics of the malpositioned disc allograft transplantation","volume":"37","author":"SK Lam","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1083\/jcb.54.3.626","article-title":"Collagen substrata for studies on cell behavior","volume":"54","author":"T Elsdale","year":"1972","journal-title":"J Cell Biol"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/BRS.0000000000000103","article-title":"Annular repair using high-density collagen gel: a rat-tail in vivo model","volume":"39","author":"P Grunert","year":"2014","journal-title":"Spine"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.actbio.2015.06.006","article-title":"Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: An in vivo study","volume":"26","author":"P Grunert","year":"2015","journal-title":"Acta Biomater"},{"issue":"16","key":"ref63","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1097\/00007632-199708150-00006","article-title":"Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study","volume":"22","author":"DS Lu","year":"1997","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:48:48Z","timestamp":1588963728000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185716"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Grasso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,20]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185716","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,20]]}}}