{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T02:41:47Z","timestamp":1787366507024,"version":"build-2736575974"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"MIUR","doi-asserted-by":"crossref","award":["PRIN 2012"],"award-info":[{"award-number":["PRIN 2012"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185822","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T17:47:13Z","timestamp":1507830433000},"page":"e0185822","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease"],"prefix":"10.1371","volume":"12","author":[{"given":"Carlo","family":"Tolone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5255-9824","authenticated-orcid":true,"given":"Giulia","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Punzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Papparella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2012.03.011","article-title":"The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention","volume":"66","author":"F Rossi","year":"2012","journal-title":"Pharmacol Res"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.dld.2008.09.001","article-title":"A common CTLA4 polymorphism confers susceptibility to autoimmune thyroid disease in celiac children","volume":"41","author":"C Tolone","year":"2009","journal-title":"Dig Liver Dis"},{"key":"ref3","article-title":"At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study","author":"L Kivel\u00e4","year":"2017","journal-title":"J Pediatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/blood-2006-07-031104","article-title":"Hematologic manifestations of celiac disease","volume":"109","author":"TR Halfdanarson","year":"2007","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1572-0241.2001.03463.x","article-title":"Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients","volume":"96","author":"B Annibale","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0300-5089(21)00352-7","article-title":"Anaemia in adult coeliac disease","volume":"3","author":"AV Hoffbrand","year":"1974","journal-title":"Clin Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(05)76459-X","article-title":"Iron-deficiency anaemia in premenopausal women","volume":"353","author":"DJ Unsworth","year":"1999","journal-title":"Lancet"},{"key":"ref8","first-page":"691","article-title":"The clinical pattern of subclinical\/silent celiac disease: an analysis on 1026 consecutive cases","volume":"94","author":"G Bottaro","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref9","first-page":"100","article-title":"How often do hematologists consider celiac disease in iron-deficiency anemia? Results of a national survey","volume":"12","author":"S Smukalla","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/ped.12448","article-title":"Changing face and clinical features of celiac disease in children","volume":"57","author":"S Gokce","year":"2015","journal-title":"Pediatr Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4318\/tjg.2013.0529","article-title":"The prevalence of celiac disease in children with iron-deficiency anemia","volume":"24","author":"V Ertekin","year":"2013","journal-title":"Turk J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/MEG.0000000000000100","article-title":"Improving detection of celiac disease patients: a prospective study in iron-deficient blood donors without anemia in north Italy","volume":"26","author":"R Cannizzaro","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","article-title":"Iron homeostasis","volume":"69","author":"NC Andrews","year":"2007","journal-title":"Annu Rev Physiol"},{"issue":"6641","key":"ref14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter","volume":"388","author":"H Gunshin","year":"1997","journal-title":"Nature"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S1357-2725(99)00065-5","article-title":"The iron transporter DMT1","volume":"31","author":"NC Andrews","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.95.3.1148","article-title":"Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport","volume":"95","author":"MD Fleming","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0888-7543(95)80053-O","article-title":"Identification and characterization of a second mouse Nramp gene","volume":"25","author":"S Gruenheid","year":"1995","journal-title":"Genomics"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1182\/blood.V93.12.4406","article-title":"Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron","volume":"93","author":"F Canonne-Hergaux","year":"1999","journal-title":"Blood"},{"issue":"19","key":"ref19","doi-asserted-by":"crossref","first-page":"12345","DOI":"10.1073\/pnas.192423399","article-title":"Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function","volume":"99","author":"N Hubert","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/j.seminhematol.2009.06.005","article-title":"Mutations in the gene encoding DMT1: clinical presentation and treatment","volume":"46","author":"A Iolascon","year":"2009","journal-title":"Semin Hematol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jtemb.2013.08.002","article-title":"Polymorphisms of metal transporter genes DMT1 and ATP7A in Wilson's disease","volume":"28","author":"A Przyby\u0142kowski","year":"2014","journal-title":"J Trace Elem Med Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exer.2012.10.003","article-title":"An association of transferrin gene polymorphism and serum transferrin levels with age-related macular degeneration","volume":"106","author":"D Wysokinski","year":"2013","journal-title":"Exp Eye Res"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neulet.2011.07.001","article-title":"DMT1 polymorphism and risk of Parkinson's disease","volume":"501","author":"Q He","year":"2011","journal-title":"Neurosci Lett"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s11033-010-0410-x","article-title":"Genotype and allele frequencies of divalent metal transporter 1 polymorphism in Turkish population","volume":"38","author":"Z Kayaalti","year":"2011","journal-title":"Mol Biol Rep"},{"issue":"36","key":"ref25","doi-asserted-by":"crossref","first-page":"15489","DOI":"10.1073\/pnas.0904880106","article-title":"Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons","volume":"106","author":"J Howitt","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/physiolgenomics.00211.2003","article-title":"Adaptive changes of duodenal iron transport proteins in celiac disease","volume":"17","author":"D Barisani","year":"2004","journal-title":"Physiol Genomics"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"S Husby","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1182\/blood-2005-07-3046","article-title":"The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?","volume":"107","author":"E Beutler","year":"2006","journal-title":"Blood"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/pbc.25861","article-title":"Deficiencies in the Management of Iron Deficiency Anemia During Childhood","volume":"63","author":"JM Powers","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/MEG.0b013e328308676b","article-title":"Differential ferritin expression is associated with iron deficiency in coeliac disease","volume":"21","author":"N Sharma","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1210\/jc.2009-1361","article-title":"Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency","volume":"94","author":"EM del Giudice","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/ijo.2010.204","article-title":"Effect of body mass index reduction on serum hepcidin levels and iron status in obese children","volume":"34","author":"A Amato","year":"2010","journal-title":"Int J Obes"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1006\/bcmd.2002.0578","article-title":"Mechanisms and regulation of intestinal iron absorption","volume":"29","author":"EH Morgan","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(01)03189-1","article-title":"Iron-dependent regulation of the divalent metal ion transporter","volume":"509","author":"H Gunshin","year":"2001","journal-title":"FEBS Lett"},{"issue":"3","key":"ref35","first-page":"384","article-title":"Expression of the DMT1 (NRAMP2\/DCT1) iron transporter in mice with genetic iron overload disorders","volume":"29","author":"F Canonne-Hergaux","year":"2001","journal-title":"Blood"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00535-007-2138-5","article-title":"Effect of erythropoietin on hepcidin, DMT1 with IRE, and hephaestin gene expression in duodenum of rats","volume":"43","author":"WN Kong","year":"2008","journal-title":"J Gastroenterol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fphar.2014.00176","article-title":"The IRP\/IRE system in vivo: insights from mouse models","volume":"5","author":"N Wilkinson","year":"2014","journal-title":"Front Pharmacol"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1073\/pnas.85.6.1787","article-title":"Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor","volume":"85","author":"JL Casey","year":"1988","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T12:51:45Z","timestamp":1659617505000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185822"}},"subtitle":[],"editor":[{"given":"Anna Carla","family":"Goldberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185822","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]}}}