{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:20:29Z","timestamp":1775647229182,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T00:00:00Z","timestamp":1506902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185850","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T17:48:41Z","timestamp":1506966521000},"page":"e0185850","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pleural effusion biomarkers and computed tomography findings in diagnosing malignant pleural mesothelioma: A retrospective study in a single center"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-9468","authenticated-orcid":true,"given":"Takehiro","family":"Otoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunkichi","family":"Ikegaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Hirabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1183\/09031936.00148211","article-title":"A prospective trial evaluating the role of mesothelin in undiagnosed pleural effusions","volume":"41","author":"CE Hooper","year":"2013","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00432-010-0834-7","article-title":"Clinical investigation of malignant mesothelioma in Japan","volume":"136","author":"N Fujimoto","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1164\/rccm.200801-063OC","article-title":"Mapping the risk of mesothelioma due to neighborhood asbestos exposure","volume":"178","author":"N Kurumatani","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1164\/rccm.200811-1729OC","article-title":"Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions","volume":"180","author":"HE Davies","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.lungcan.2015.05.014","article-title":"Treatment patterns and survival analysis in 9014 patients with malignant pleural mesothelioma from Belgium, the Netherlands and England","volume":"89","author":"RA Damhuis","year":"2015","journal-title":"Lung Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1378\/chest.119.4.1138","article-title":"Diagnostic value of CYFRA 21\u20131 tumor marker and CEA in pleural effusion due to mesothelioma","volume":"119","author":"M Paganuzzi","year":"2001","journal-title":"Chest"},{"key":"ref7","first-page":"4343","article-title":"Cytokeratin 19 fragment\/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma","volume":"30","author":"H Suzuki","year":"2010","journal-title":"Anticancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"413946","DOI":"10.1155\/2014\/413946","article-title":"Pleural fluid mesothelin as an adjunct to the diagnosis of pleural malignant mesothelioma","volume":"2014","author":"J Creaney","year":"2014","journal-title":"Dis Markers"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s12032-013-0543-6","article-title":"Diagnostic value of mesothelin in pleural fluids: comparison with CYFRA 21\u20131 and CEA","volume":"30","author":"R Filiberti","year":"2013","journal-title":"Med Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/thx.2006.068114","article-title":"Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma","volume":"62","author":"J Creaney","year":"2007","journal-title":"Thorax"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1164\/rccm.200511-1789OC","article-title":"Soluble mesothelin-related peptides in the diagnosis of malignant pleural mesothelioma","volume":"173","author":"A Scherpereel","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","first-page":"7425","article-title":"Mesothelin in serum and pleural effusion in the diagnosis of malignant pleural mesothelioma with non-positive cytology","volume":"34","author":"MC Franceschini","year":"2014","journal-title":"Anticancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12032-013-0649-x","article-title":"Clinical value of mesothelin in pleural effusions versus histology by medical thoracoscopy: brief report","volume":"30","author":"PA Canessa","year":"2013","journal-title":"Med Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3892\/etm_00000048","article-title":"Soluble mesothelin-related protein in pleural effusion from patients with malignant pleural mesothelioma","volume":"1","author":"N Fujimoto","year":"2010","journal-title":"Exp Ther Med"},{"key":"ref15","first-page":"2707","article-title":"Mesothelin is more useful in pleural effusion than in serum in the diagnosis of pleural mesothelioma","volume":"33","author":"P Ferro","year":"2013","journal-title":"Anticancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.athoracsur.2007.07.042","article-title":"Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusions","volume":"85","author":"HI Pass","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/07357907.2012.749265","article-title":"Evaluation of soluble mesothelin-related peptide as a diagnostic marker of malignant pleural mesothelioma effusions: its contribution to cytology","volume":"31","author":"PA Canessa","year":"2013","journal-title":"Cancer Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2105-16-S9-S3","article-title":"Differential diagnosis of pleural mesothelioma using Logic Learning Machine","volume":"16","author":"S Parodi","year":"2015","journal-title":"BMC bioinformatics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1515\/CCLM.2011.242","article-title":"Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma","volume":"49","author":"S Yamada","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.medcli.2008.11.047","article-title":"Pleural fluid mesothelin for the differential diagnosis of exudative pleural effusions","volume":"133","author":"C Aleman","year":"2009","journal-title":"Med Clin"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2214\/ajr.154.3.2106209","article-title":"CT in differential diagnosis of diffuse pleural disease","volume":"154","author":"AN Leung","year":"1990","journal-title":"Am J Roentgenol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1440-1843.1998.00069.x","article-title":"Computed tomographic findings of environmental asbestos-related malignant pleural mesothelioma","volume":"3","author":"UM Yilmaz","year":"1998","journal-title":"Respirology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0720-048X(01)00426-0","article-title":"Computed tomography features in malignant pleural mesothelioma and other commonly seen pleural diseases","volume":"41","author":"M Metintas","year":"2002","journal-title":"Eur J Radiol"},{"key":"ref24","first-page":"261","article-title":"Fundamental evaluation of Lumipulse mesothelin","volume":"65","author":"M Nakamachi","year":"2011","journal-title":"Igaku to Yakugaku"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"ii4","DOI":"10.1136\/thx.2010.136978","article-title":"Investigation of a unilateral pleural effusion in adults: British Thoracic Society Pleural Disease Guideline 2010","volume":"65","author":"C Hooper","year":"2010","journal-title":"Thorax"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1378\/chest.109.2.414","article-title":"Combined use of pleural adenosine deaminase with lymphocyte\/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis","volume":"109","author":"LJ Burgess","year":"1996","journal-title":"Chest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1037\/h0026256","article-title":"Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit","volume":"70","author":"J Cohen","year":"1968","journal-title":"Psychol Bull"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.resinv.2013.02.002","article-title":"Hyaluronic acid in the pleural fluid of patients with malignant pleural mesothelioma","volume":"51","author":"N Fujimoto","year":"2013","journal-title":"Respir Investig"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1378\/chest.94.5.1037","article-title":"Concentration of hyaluronic acid in pleural fluid as a diagnostic aid for malignant mesothelioma","volume":"94","author":"T Pettersson","year":"1988","journal-title":"Chest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"PF Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"RJ Little","year":"2012","journal-title":"N Engl J Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:12:12Z","timestamp":1589015532000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185850"}},"subtitle":[],"editor":[{"given":"Hyun-Sung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,2]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185850","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,2]]}}}