{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:41:12Z","timestamp":1792449672160,"version":"4.5.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011781","name":"Shriners Hospital for Children","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185937","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T13:49:27Z","timestamp":1507211367000},"page":"e0185937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Adipose-derived stem cells attenuate pulmonary microvascular hyperpermeability after smoke inhalation"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-8114","authenticated-orcid":true,"given":"Koji","family":"Ihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baigalmaa","family":"Enkhtaivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dannelys","family":"Perez-Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Hanif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Prough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perenlei","family":"Enkhbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"MA Matthay","year":"2012","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1586\/ers.09.21","article-title":"Pathophysiology, management and treatment of smoke inhalation injury","volume":"3","author":"S Rehberg","year":"2009","journal-title":"Expert Rev Respir Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(16)31458-1","article-title":"Pathophysiology, research challenges, and clinical management of smoke inhalation injury","volume":"388","author":"P Enkhbaatar","year":"2016","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.0000135902.99383.6f","article-title":"Mesenchymal stem cells and their potential as cardiac therapeutics","volume":"95","author":"MF Pittenger","year":"2004","journal-title":"Circ Res"},{"key":"ref5","first-page":"1439","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"K Le Blanc","year":"2004","journal-title":"Lanset"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/70986","article-title":"Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord","volume":"5","author":"JW McDonald","year":"1999","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"M Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"MF Pittenger","year":"1999","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"G Chamberlain","year":"2007","journal-title":"Stem Cells"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: clinical applications and biological characterization","volume":"36","author":"FP Barry","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S2213-2600(14)70217-6","article-title":"Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis","volume":"2","author":"J Walter","year":"2014","journal-title":"Lancet Respir Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S2213-2600(14)70291-7","article-title":"Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial","volume":"3","author":"JG Wilson","year":"2015","journal-title":"Lancet Respir Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13613-014-0022-z","article-title":"Design and implementation of the START (Stem cells for ARDS Treatment) trial, a phase \u00bd trial of human mesenchymal stem\/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome","volume":"4","author":"KD Liu","year":"2014","journal-title":"Ann Intensive Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/thoraxjnl-2013-204980","article-title":"Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia","volume":"69","author":"S Asmussen","year":"2014","journal-title":"Thorax"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"L1233","DOI":"10.1152\/ajplung.2001.280.6.L1233","article-title":"Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep","volume":"280","author":"K Soejima","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-4804(75)90056-6","article-title":"Preparation of chronic lung lymph fistulas in sheep","volume":"19","author":"NC Staub","year":"1975","journal-title":"J Surg Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/jappl.1988.64.3.1107","article-title":"Increasing duration of smoke exposure induces more severe lung injury in sheep","volume":"64","author":"R Kimura","year":"1988","journal-title":"J Appl Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.shk.0000191338.39154.73","article-title":"Inhalational and acute lung injury","volume":"24","author":"DL Traber","year":"2005","journal-title":"Shock"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1378\/chest.10-0518","article-title":"Therapeutic potential of mesenchymal stem cells for severe acute lung injury","volume":"138","author":"MA Matthay","year":"2010","journal-title":"Chest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/stem.643","article-title":"Mesenchymal stem cells for acute lung injury: Role of paracrine soluble factors","volume":"29","author":"JW Lee","year":"2011","journal-title":"Stem Cells"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"MN Islam","year":"2012","journal-title":"Nat Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1165\/rcmb.2004-0330OC","article-title":"Bone marrow-derived mesenchymal stem cells in repair of the injured lung","volume":"33","author":"M Rojas","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1476-9255-9-33","article-title":"Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats","volume":"9","author":"J Li","year":"2012","journal-title":"J Inflamm (Lond)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/scrt161","article-title":"Comparison of the therapeutic effects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury","volume":"4","author":"S Zhang","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"832","DOI":"10.5966\/sctm.2015-0006","article-title":"Study of bone marrow and embryonic stem cell-derived human mesenchymal stem cells for treatment of Escherichia coli endotoxin-induced acute lung injury in mice","volume":"4","author":"Q Hao","year":"2015","journal-title":"Stem Cell Transl Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1089\/hum.2009.147","article-title":"Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury","volume":"21","author":"E Manning","year":"2010","journal-title":"Hum Gene Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1073\/pnas.0704421104","article-title":"Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury","volume":"104","author":"LA Ortiz","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12192-012-0331-9","article-title":"Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity","volume":"17","author":"M Mohammadzadeh","year":"2012","journal-title":"Cell Stress Chperones"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4103\/0366-6999.150106","article-title":"Mesenchymal stem cell attenuates neutrophil-predominant inflammation and acute lung injury in an in vivo rat model of ventilator-induced lung injury","volume":"128","author":"TS Lai","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e25171","DOI":"10.1371\/journal.pone.0025171","article-title":"Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock","volume":"6","author":"S Pati","year":"2011","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/CS20040135","article-title":"Pathophysiology of acute lung injury in combined burn and smoke inhalation injury","volume":"107","author":"P Enkhbaatar","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1164\/ajrccm.163.3.9912052","article-title":"Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury","volume":"163","author":"K Soejima","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/rccm.200209-1031PP","article-title":"The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury","volume":"167","author":"P Enkhbaatar","year":"2003","journal-title":"Am J Respr Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/01902140600574967","article-title":"Acute bronchial obstruction in sheep: histopathology and gland cytokine expression","volume":"31","author":"RA Cox","year":"2005","journal-title":"Exp Lung Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pupt.2006.03.013","article-title":"Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance","volume":"20","author":"RA Cox","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/01902148.2012.663453","article-title":"Time course of the inflammatory and oxidative stress response to pulmonary infection in mice","volume":"38","author":"M Lange","year":"2012","journal-title":"Exp Lung Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/SHK.0b013e31824b1793","article-title":"Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis","volume":"37","author":"M Lange","year":"2012","journal-title":"Shock"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1097\/CCM.0b013e318298ad3a","article-title":"Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury","volume":"41","author":"S Rehberg","year":"2013","journal-title":"Crit Care Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1165\/rcmb.2012-0274OC","article-title":"Lipoxin A(4) activates alveolar epithelial sodium channel, Na, K-ATPase, and increases alveolar fluid clearance","volume":"48","author":"Q Wang","year":"2013","journal-title":"Am J Resp Cell Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.1500244","article-title":"Human mesenchymal stem (stromal) cells promote the resolution of acute lung injury in part through lipoxin A4","volume":"195","author":"XH Fang","year":"2015","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.CCM.0000251640.77679.D7","article-title":"Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators","volume":"35","author":"SE Orfanos","year":"2007","journal-title":"Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/thx.2007.087387","article-title":"Angiopoietin-2, permeability oedema, occurrence and severity of ALI\/ARDS in septic and non-septic critically ill patients","volume":"63","author":"M Van der Heijden","year":"2008","journal-title":"Thorax"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.pmed.0030046","article-title":"Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans","volume":"3","author":"SM Parikh","year":"2006","journal-title":"PLoS Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.transproceed.2006.12.019","article-title":"Stem cell transplantation: The lung barrier","volume":"39","author":"S Schrepfer","year":"2007","journal-title":"Transplant Proc"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect","volume":"18","author":"UM Fischer","year":"2009","journal-title":"Stem Cell Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.CIR.0000084828.50310.6A","article-title":"Systemic delivery of bone marrow\u2013derived mesenchymal stem cells to the infarcted myocardium feasibility, cell migration, and body distribution","volume":"108","author":"IM Barbash","year":"2003","journal-title":"Circulation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:55:41Z","timestamp":1570164941000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185937"}},"subtitle":[],"editor":[{"given":"Yu Ru","family":"Kou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185937","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]}}}