{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:33:09Z","timestamp":1777591989517,"version":"3.51.4"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nacional Academy of Sciences of Ukraine","award":["0115U002970"],"award-info":[{"award-number":["0115U002970"]}]},{"DOI":"10.13039\/501100004742","name":"National Academy of Sciences of Ukraine","doi-asserted-by":"publisher","award":["0116U007817"],"award-info":[{"award-number":["0116U007817"]}],"id":[{"id":"10.13039\/501100004742","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Allergy and Infectious Diseases (US)","award":["AI52203"],"award-info":[{"award-number":["AI52203"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0185940","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T17:49:38Z","timestamp":1507225778000},"page":"e0185940","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling"],"prefix":"10.1371","volume":"12","author":[{"given":"Inna","family":"Gordiienko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larysa","family":"Shlapatska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriia","family":"Kholodniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Sklyarenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Gluzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-8006","authenticated-orcid":true,"given":"Svetlana P.","family":"Sidorenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrc.2016.8","article-title":"The molecular pathogenesis of chronic lymphocytic leukaemia","volume":"16","author":"G Fabbri","year":"2016","journal-title":"Nat Rev Cancer"},{"issue":"7574","key":"ref2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature15395","article-title":"Mutations driving CLL and their evolution in progression and relapse","volume":"526","author":"DA Landau","year":"2015","journal-title":"Nature"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng.3488","article-title":"DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia","volume":"48","author":"CC Oakes","year":"2016","journal-title":"Nat Genet"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood-2015-02-585042","article-title":"Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia","volume":"126","author":"R Guieze","year":"2015","journal-title":"Blood"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3109\/10428194.2013.867486","article-title":"Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia","volume":"55","author":"PY Huang","year":"2014","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.imlet.2010.09.017","article-title":"Cluster analysis of immunophenotypic data: the example of chronic lymphocytic leukemia","volume":"134","author":"A Zucchetto","year":"2011","journal-title":"Immunol Lett"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3324\/haematol.2014.119123","article-title":"The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia","volume":"100","author":"A Wiestner","year":"2015","journal-title":"Haematologica"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1182\/blood-2015-03-585075","article-title":"Targeted therapies in CLL: mechanisms of resistance and strategies for management","volume":"126","author":"JA Woyach","year":"2015","journal-title":"Blood"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3324\/haematol.2013.098384","article-title":"The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy","volume":"99","author":"G Packham","year":"2014","journal-title":"Haematologica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-020712-163955","article-title":"The pathogenesis of chronic lymphocytic leukemia","volume":"9","author":"S Zhang","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.4049\/jimmunol.151.9.4614","article-title":"Characterization of a cell surface glycoprotein IPO-3, expressed on activated human B and T lymphocytes","volume":"151","author":"SP Sidorenko","year":"1993","journal-title":"J Immunol"},{"issue":"6537","key":"ref12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/376260a0","article-title":"A novel receptor involved in T-cell activation","volume":"376","author":"BG Cocks","year":"1995","journal-title":"Nature"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ni0103-19","article-title":"The dual-function CD150 receptor subfamily: the viral attraction","volume":"4","author":"SP Sidorenko","year":"2003","journal-title":"Nat Immunol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/icb.2010.145","article-title":"SLAM (CD150) is a multitasking immunoreceptor: from cosignalling to bacterial recognition","volume":"89","author":"J Sintes","year":"2011","journal-title":"Immunol Cell Biol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ni.1931","article-title":"SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages","volume":"11","author":"SB Berger","year":"2010","journal-title":"Nat Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.coi.2015.11.003","article-title":"SLAM family receptors in normal immunity and immune pathologies","volume":"38","author":"N Wu","year":"2016","journal-title":"Curr Opin Immunol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"e28277","DOI":"10.1371\/journal.pone.0028277","article-title":"A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia","volume":"6","author":"CD Schweighofer","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1172\/JCI83013","article-title":"SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response","volume":"126","author":"C Bologna","year":"2016","journal-title":"J Clin Invest"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1084\/jem.185.6.993","article-title":"Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes","volume":"185","author":"J Punnonen","year":"1997","journal-title":"J Exp Med"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"e0118302","DOI":"10.1371\/journal.pone.0118302","article-title":"Expression of CD150 in tumors of the central nervous system: identification of a novel isoform","volume":"10","author":"O Romanets-Korbut","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2141.2005.05775.x","article-title":"Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes","volume":"131","author":"N Porakishvili","year":"2005","journal-title":"Br J Haematol"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.4049\/jimmunol.1100198","article-title":"Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway","volume":"187","author":"JW Chaplin","year":"2011","journal-title":"J Immunol"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1084\/jem.20130188","article-title":"Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory","volume":"210","author":"JW Chaplin","year":"2013","journal-title":"J Exp Med"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1189\/jlb.2VMR1215-582R","article-title":"The RP105\/MD-1 complex: molecular signaling mechanisms and pathophysiological implications","volume":"101","author":"TE Schultz","year":"2017","journal-title":"J Leukoc Biol"},{"issue":"3","key":"ref25","first-page":"162","article-title":"Intrinsic defect in B-lymphoblastoid cell lines from patients with X-linked lymphoproliferative disease type 1. II. receptor-mediated Akt\/PKB and ERK1\/2 activation and transcription factors expression profile","volume":"36","author":"LM Shlapatska","year":"2014","journal-title":"Exp Oncol"},{"issue":"1","key":"ref26","first-page":"9","article-title":"CD150-mediated Akt signalling pathway in normal and malignant B cells","volume":"33","author":"M Yurchenko","year":"2011","journal-title":"Exp Oncol"},{"issue":"13","key":"ref27","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1182\/blood-2004-04-1273","article-title":"The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells","volume":"104","author":"SV Mikhalap","year":"2004","journal-title":"Blood"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/icb.2010.14","article-title":"CD150 regulates JNK1\/2 activation in normal and Hodgkin&apos;s lymphoma B cells","volume":"88","author":"MY Yurchenko","year":"2010","journal-title":"Immunol Cell Biol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.imlet.2010.09.021","article-title":"Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cells","volume":"134","author":"J De Salort","year":"2011","journal-title":"Immunol Lett"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.imlet.2010.09.015","article-title":"Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation","volume":"134","author":"B Rodriguez-Bayona","year":"2011","journal-title":"Immunol Lett"},{"issue":"1","key":"ref31","first-page":"3","article-title":"Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping","volume":"39","author":"SP Sidorenko","year":"1992","journal-title":"Neoplasma"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.imlet.2010.09.022","article-title":"New monoclonal antibodies against B-cell antigens: possible new strategies for diagnosis of primary cutaneous B-cell lymphomas","volume":"134","author":"D Fanoni","year":"2011","journal-title":"Immunol Lett"},{"issue":"3","key":"ref33","first-page":"186","article-title":"Immunohistochemical studies of CD150 expression in some human tumors","volume":"25","author":"O.V. Yurchenko","year":"2003","journal-title":"Experimental Oncology"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cyto.b.21279","article-title":"Multiple myeloma: New surface antigens for the characterization of plasma cells in the era of novel agents","volume":"90","author":"VE Muccio","year":"2016","journal-title":"Cytometry B Clin Cytom"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.31768\/2312-8852.2016.38(2):101-107","article-title":"Differential expression of CD150\/SLAMF1 in normal and malignant B cells on the different stages of maturation","volume":"38","author":"IM Gordiienko","year":"2016","journal-title":"Exp Oncol"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02255-16","article-title":"The measles virus receptor SLAMF1 can mediate particle endocytosis","volume":"91","author":"D Goncalves-Carneiro","year":"2017","journal-title":"J Virol"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2119\/molmed.2014.00265","article-title":"Rewiring of sIgM-mediated intracellular signaling through the CD180 Toll-like receptor","volume":"21","author":"N Porakishvili","year":"2015","journal-title":"Mol Med"},{"issue":"36","key":"ref38","doi-asserted-by":"crossref","first-page":"28100","DOI":"10.1074\/jbc.M004117200","article-title":"Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity","volume":"275","author":"N Mavaddat","year":"2000","journal-title":"J Biol Chem"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.devcel.2007.03.020","article-title":"The two TORCs and Akt","volume":"12","author":"PT Bhaskar","year":"2007","journal-title":"Dev Cell"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"R Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"19","key":"ref41","doi-asserted-by":"crossref","first-page":"14056","DOI":"10.1074\/jbc.M700906200","article-title":"RAS\/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation","volume":"282","author":"PP Roux","year":"2007","journal-title":"J Biol Chem"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation","volume":"36","author":"MC Mendoza","year":"2011","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"W Zhang","year":"2002","journal-title":"Cell Res"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.1600915","article-title":"Functional differences between IgM and IgD signaling in chronic lymphocytic leukemia","volume":"197","author":"E Ten Hacken","year":"2016","journal-title":"J Immunol"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1182\/blood-2007-12-127688","article-title":"BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells","volume":"112","author":"A Guarini","year":"2008","journal-title":"Blood"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.4049\/jimmunol.162.10.5719","article-title":"CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis","volume":"162","author":"SV Mikhalap","year":"1999","journal-title":"J Immunol"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.4049\/jimmunol.166.9.5480","article-title":"CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A","volume":"166","author":"LM Shlapatska","year":"2001","journal-title":"J Immunol"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1478-811X-10-21","article-title":"Functions of the Lyn tyrosine kinase in health and disease","volume":"10","author":"E Ingley","year":"2012","journal-title":"Cell Commun Signal"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1074\/jbc.M006820200","article-title":"The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells","volume":"276","author":"AK Somani","year":"2001","journal-title":"J Biol Chem"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"EK Kim","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ceb.2009.11.005","article-title":"TOR-dependent control of autophagy: biting the hand that feeds","volume":"22","author":"TP Neufeld","year":"2010","journal-title":"Curr Opin Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0185940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T20:40:09Z","timestamp":1693082409000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0185940"}},"subtitle":[],"editor":[{"given":"Spencer B.","family":"Gibson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0185940","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]}}}