{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:35:32Z","timestamp":1785245732662,"version":"3.55.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["19703"],"award-info":[{"award-number":["19703"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186096","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T13:50:05Z","timestamp":1507816205000},"page":"e0186096","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Triggers of acute attacks of gout, does age of gout onset matter? A primary care based cross-sectional study"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-4919","authenticated-orcid":true,"given":"Abhishek","family":"Abhishek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Valdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.rdc.2014.01.001","article-title":"Epidemiology of gout","volume":"40","author":"E Roddy","year":"2014","journal-title":"Rheumatic diseases clinics of North America"},{"issue":"10055","key":"ref2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"N Dalbeth","year":"2016","journal-title":"Lancet (London, England)"},{"key":"ref3","article-title":"Online patient information resources on gout provide inadequate information and minimal emphasis on potentially curative urate lowering treatment","author":"LM Jimenez-Linan","year":"2016","journal-title":"Arthritis care & research"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1002\/art.34677","article-title":"Cherry consumption and decreased risk of recurrent gout attacks","volume":"64","author":"Y Zhang","year":"2012","journal-title":"Arthritis and rheumatism"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/art.38917","article-title":"Nocturnal risk of gout attacks","volume":"67","author":"HK Choi","year":"2015","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/annrheumdis-2011-201215","article-title":"Purine-rich foods intake and recurrent gout attacks","volume":"71","author":"Y Zhang","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.amjmed.2013.12.019","article-title":"Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study","volume":"127","author":"T Neogi","year":"2014","journal-title":"The American journal of medicine"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"800 e13","DOI":"10.1016\/j.amjmed.2006.01.020","article-title":"Alcohol consumption as a trigger of recurrent gout attacks","volume":"119","author":"Y Zhang","year":"2006","journal-title":"The American journal of medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12891-015-0661-8","article-title":"Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares","volume":"16","author":"TJ Flynn","year":"2015","journal-title":"BMC musculoskeletal disorders"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/art.20761","article-title":"Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey","volume":"52","author":"HK Choi","year":"2005","journal-title":"Arthritis and rheumatism"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/annrheumdis-2014-206564","article-title":"Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra","volume":"75","author":"TO Crisan","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/art.27667","article-title":"Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis","volume":"62","author":"LA Joosten","year":"2010","journal-title":"Arthritis and rheumatism"},{"issue":"7081","key":"ref13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"F Martinon","year":"2006","journal-title":"Nature"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/annrheumdis-2012-201676","article-title":"Patients with gout adhere to curative treatment if informed appropriately: proof-of-concept observational study","volume":"72","author":"F Rees","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/rheumatology\/kew235","article-title":"Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks","volume":"55","author":"AM Valdes","year":"2016","journal-title":"Rheumatology (Oxford, England)"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/acr.22855","article-title":"Association of Serum Uric Acid and Disease Duration With Frequent Gout Attacks: A Case-Control Study","volume":"68","author":"A Abhishek","year":"2016","journal-title":"Arthritis care & research"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","article-title":"Preliminary criteria for the classification of the acute arthritis of primary gout","volume":"20","author":"SL Wallace","year":"1977","journal-title":"Arthritis and rheumatism"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.amjmed.2013.12.019","article-title":"Alcohol quantity and type on risk of recurrent gout attacks: An internet-based case-crossover study","volume":"127","author":"T Neogi","year":"2014","journal-title":"The American journal of medicine"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1249\/00005768-198802000-00008","article-title":"Differential effects of exercise intensity on serum uric acid concentration","volume":"20","author":"HJ Green","year":"1988","journal-title":"Medicine and science in sports and exercise"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1172\/JCI104172","article-title":"THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY","volume":"39","author":"JS Handler","year":"1960","journal-title":"Journal of Clinical Investigation"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2842.2007.01732.x","article-title":"Serum markers of chronic dehydration are associated with saliva spinability","volume":"34","author":"A Yoshihara","year":"2007","journal-title":"Journal of oral rehabilitation"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1136\/ard.2008.096693","article-title":"Seasonality and trends in the incidence and prevalence of gout in England and Wales 1994\u20132007","volume":"68","author":"AJ Elliot","year":"2009","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10067-015-3042-7","article-title":"Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample","volume":"35","author":"P Karmacharya","year":"2016","journal-title":"Clinical rheumatology"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.1620910114","article-title":"Uric acid priming in human monocytes is driven by the AKT\u2013PRAS40 autophagy pathway","volume":"114","author":"TO Cri\u015fan","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1194\/jlr.D029546","article-title":"Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways","volume":"53","author":"S Huang","year":"2012","journal-title":"Journal of Lipid Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"751374","DOI":"10.1155\/2013\/751374","article-title":"Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice","volume":"2013","author":"DA DeSantis","year":"2013","journal-title":"Mediators of inflammation"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1189\/jlb.1212659","article-title":"Alcohol-induced IL-1beta in the brain is mediated by NLRP3\/ASC inflammasome activation that amplifies neuroinflammation","volume":"94","author":"D Lippai","year":"2013","journal-title":"Journal of leukocyte biology"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"J Petrasek","year":"2012","journal-title":"Journal of Clinical Investigation"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/rheumatology\/kem056a","article-title":"British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout","volume":"46","author":"KM Jordan","year":"2007","journal-title":"Rheumatology (Oxford, England)"},{"issue":"10","key":"ref30","first-page":"13747","article-title":"rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout","volume":"8","author":"J Deng","year":"2015","journal-title":"International journal of clinical and experimental pathology"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1159\/000373960","article-title":"CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population","volume":"35","author":"Y Chen","year":"2015","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/03009742.2012.726372","article-title":"IL-8 -251T\/A and IL-12B 1188A\/C polymorphisms are associated with gout in a Chinese male population","volume":"42","author":"S Liu","year":"2013","journal-title":"Scandinavian journal of rheumatology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13075-015-0802-3","article-title":"Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout","volume":"17","author":"C McKinney","year":"2015","journal-title":"Arthritis research & therapy"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147939","article-title":"The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets","volume":"11","author":"H Rasheed","year":"2016","journal-title":"PloS one"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"e64845","DOI":"10.1371\/journal.pone.0064845","article-title":"Association of TLR4 Gene rs2149356 polymorphism with primary gouty arthritis in a case-control study","volume":"8","author":"YF Qing","year":"2013","journal-title":"PloS one"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1136\/annrheumdis-2015-208237","article-title":"2015 Gout classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"74","author":"T Neogi","year":"2015","journal-title":"Annals of the Rheumatic Diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:24:03Z","timestamp":1540340643000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186096"}},"subtitle":[],"editor":[{"given":"Gotthard","family":"Kunze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186096","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]}}}