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The Cochrane Collaboration"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"D Moher","year":"2009","journal-title":"BMJ"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"e2130","DOI":"10.1371\/journal.pntd.0002130","article-title":"Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis","volume":"7","author":"P Olliaro","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","unstructured":"Wells G, Shea B, O\u2019connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2011. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohrica\/programs\/clinical_epidemiology\/oxford asp\" xlink:type=\"simple\">http:\/\/www.ohrica\/programs\/clinical_epidemiology\/oxford asp<\/ext-link>. 2014."},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"CB Begg","year":"1994","journal-title":"Biometrics"},{"issue":"4","key":"ref23","first-page":"294","article-title":"Tratamiento de la leishmaniasis cutanea con ketoconazol","volume":"12","author":"M Restrepo","year":"1987","journal-title":"Acta Med Colomb"},{"key":"ref24","first-page":"32","article-title":"Efectividad del NysoralR (Ketoconazol) para el tratamiento de las leishmaniasis cut\u00e1nea y cut\u00e1neomucosa en Trujillo, Venezuela","volume":"28","author":"JV Scorza","year":"1988","journal-title":"Bol. 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Evaluation of therapeutic efficacy of fluconazole in human cutaneous leishmaniasis. Ph.D.Thesis, Universidade Federal do Cear\u00e1. 2012. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.repositorio.ufc.br\/bitstream\/riufc\/5552\/1\/2012_tese_cglsilva.pdf\" xlink:type=\"simple\">http:\/\/www.repositorio.ufc.br\/bitstream\/riufc\/5552\/1\/2012_tese_cglsilva.pdf<\/ext-link>"},{"issue":"3","key":"ref53","first-page":"365","article-title":"Epidemiology, pathology and treatment of cutaneous leishmaniasis in taif region of saudi Arabia","volume":"9","author":"W Khan","year":"2014","journal-title":"Iran J Parasitol"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cid\/ciw662","article-title":"Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial","volume":"64","author":"FV Prates","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0035-9203(86)90239-7","article-title":"Failure to cure Leishmania braziliensis guyanensis cutaneous leishmaniasis with oral ketoconazole","volume":"80","author":"JP Dedet","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6\u20137","key":"ref56","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0399-077X(87)80054-9","article-title":"Efficacite du ketoconazole dans le traitement de la leishmaniose cutanee a leishmania major en Tunisia","volume":"17","author":"A Zahaf","year":"1987","journal-title":"Med Maladies Infect"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00417211","article-title":"Efficacy of ketoconazole in cutaneous leishmaniasis","volume":"275","author":"L Weinrauch","year":"1983","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2230.1986.tb00425.x","article-title":"Cutaneous leishmaniasis from Belize\u2014treatment with ketoconazole","volume":"11","author":"DS Jolliffe","year":"1986","journal-title":"Clin Exp Dermatol"},{"issue":"2","key":"ref59","first-page":"105","article-title":"An attempt to treat skin ulcer caused by Leishmania braziliensis braziliensis with ketoconazole","volume":"22","author":"EM Netto","year":"1989","journal-title":"Rev Soc Bras Med Trop"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.20453\/rmh.v13i4.690","article-title":"Tratamiento de leishmaniasis cut\u00e1nea andina con ketoconazol en dos zonas de alta incid\u00eancia del Departamento de Amazonas: Reporte de Casos","volume":"13","author":"JC Pita","year":"2002","journal-title":"Rev. M\u00e9d. Hered"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2230.2004.01561.x","article-title":"Cutaneous leishmaniasis in a Kosovan child treated with oral fluconazole","volume":"29","author":"S Baron","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-4632.2004.02429.x","article-title":"Cutaneous leishmaniasis: successful treatment with itraconazole","volume":"45","author":"J Consigli","year":"2006","journal-title":"International Journal of Dermatology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0028-2243(86)90109-7","article-title":"Itraconazole pharmacokinetics in female genital tract: plasma and tissue levels in patients undergoing hysterectomy after a single dose of 200 mg itraconazole","volume":"23","author":"E Larosa","year":"1986","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"Suppl 1","key":"ref64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1439-0507.1989.tb02296.x","article-title":"The clinical pharmacokinetics of itraconazole: an overview","volume":"32","author":"J Heykants","year":"1989","journal-title":"Mycoses"},{"key":"ref65","first-page":"71","article-title":"Status of the american tegumentary leishmaniasis in the state of Rio de Janeiro, Brazil, from 2004 to 2013","volume":"58","author":"GF Vita","year":"2016","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s15010-013-0500-5","article-title":"Cutaneous leishmaniasis in Switzerland: first experience with species-specific treatment","volume":"41","author":"V Mosimann","year":"2013","journal-title":"Infection"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2230.2004.01677.x","article-title":"Changing pattern of imported cutaneous leishmaniasis in the Netherlands","volume":"30","author":"JE Zeegelaar","year":"2005","journal-title":"Clin Exp Dermatol"},{"issue":"2","key":"ref68","doi-asserted-by":"crossref","first-page":"e0149697","DOI":"10.1371\/journal.pone.0149697","article-title":"The Cure Rate after Placebo or No Therapy in American Cutaneous Leishmaniasis: A Systematic Review and Meta-Analysis","volume":"11","author":"GF Cota","year":"2016","journal-title":"PLoS One"},{"issue":"9263","key":"ref69","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(00)04337-3","article-title":"The CONSORT Statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"357","author":"D Moher","year":"2001","journal-title":"The Lancet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:02:05Z","timestamp":1589007725000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186117"}},"subtitle":[],"editor":[{"given":"Henk D. 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