{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:44Z","timestamp":1792000544657,"version":"4.4.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00259"],"award-info":[{"award-number":["PI15\/00259"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/01806"],"award-info":[{"award-number":["PI12\/01806"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007752","name":"Agencia La\u00edn Entralgo","doi-asserted-by":"publisher","award":["RS_AP10\/6"],"award-info":[{"award-number":["RS_AP10\/6"]}],"id":[{"id":"10.13039\/501100007752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186220","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T13:49:43Z","timestamp":1509025783000},"page":"e0186220","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study"],"prefix":"10.1371","volume":"12","author":[{"given":"V.","family":"Cornejo del R\u00edo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mostaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lahoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"S\u00e1nchez-Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sab\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Patr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fern\u00e1ndez-Puntero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vicent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Montesano-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Garc\u00eda-Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gonz\u00e1lez-Alegre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Estirado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Laguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"de Burgos-Lunar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"G\u00f3mez-Campelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Abanades-Herranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"de Miguel-Yanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Salinero-Fort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf SPREDIA-2 Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.CIR.88.3.837","article-title":"Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study (CHS) Collaborative Research Group","volume":"88","author":"AB Newman","year":"1993","journal-title":"Circulation"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/01.ATV.0000168911.78624.b7","article-title":"Sensitivity and specificity of the ankle-brachial index to predict future cardiovascular outcomes: a systematic review","volume":"25","author":"AV Doobay","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ejvs.2010.02.009","article-title":"Characteristics and outcome of patients hospitalised for lower extremity peripheral artery disease in France: the COPART Registry","volume":"39","author":"JP Cambou","year":"2010","journal-title":"Eur J Vasc Endovasc Surg Off J Eur Soc Vasc Surg"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1161\/CIRCULATIONAHA.106.174526","article-title":"ACC\/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery\/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC\/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation","volume":"113","author":"AT Hirsch","year":"2006","journal-title":"Circulation"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cjca.2012.06.014","article-title":"Diagnostic value of ankle-brachial index in peripheral arterial disease: a meta-analysis","volume":"29","author":"D Xu","year":"2013","journal-title":"Can J Cardiol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1161\/01.CIR.101.1.e16","article-title":"Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III","volume":"101","author":"P Greenland","year":"2000","journal-title":"Circulation"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.CIR.0000137913.26087.F0","article-title":"Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999\u20132000","volume":"110","author":"E Selvin","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ajh.2012.13","article-title":"Associations of noninvasive measures of arterial compliance and ankle-brachial index: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"25","author":"JT Wilkins","year":"2012","journal-title":"Am J Hypertens"},{"issue":"1","key":"ref9","first-page":"5","article-title":"Peripheral arteriopathy in type 2 diabetes mellitus","volume":"22","author":"M Bund\u00f3","year":"1998","journal-title":"Aten Primaria"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1067\/mva.2002.120030","article-title":"Age at onset of smoking is an independent risk factor in peripheral artery disease development","volume":"35","author":"A Planas","year":"2002","journal-title":"J Vasc Surg"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1177\/0003319714556651","article-title":"Peripheral Arterial Disease and Cardiovascular Risk: The Role of Mediterranean Diet","volume":"66","author":"C Chrysohoou","year":"2015","journal-title":"Angiology"},{"issue":"14","key":"ref12","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","article-title":"Primary prevention of cardiovascular disease with a Mediterranean diet","volume":"368","author":"R Estruch","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejvs.2009.04.013","article-title":"Prevalence of symptomatic and asymptomatic peripheral arterial disease and the value of the ankle-brachial index to stratify cardiovascular risk","volume":"38","author":"R Ramos","year":"2009","journal-title":"Eur J Vasc Endovasc Surg Off J Eur Soc Vasc Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2458-10-38","article-title":"The peripheral arterial disease study (PERART\/ARTPER): prevalence and risk factors in the general population","volume":"10","author":"MT Alzamora","year":"2010","journal-title":"BMC Public Health"},{"issue":"1","key":"ref15","first-page":"20","article-title":"Prevalence of peripheral artery disease and its associated risk factors in Spain: The ESTIME Study","volume":"28","author":"JI Blanes","year":"2009","journal-title":"Int Angiol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.numecd.2005.08.009","article-title":"Using ankle-brachial index to detect peripheral arterial disease: prevalence and associated risk factors in a random population sample","volume":"17","author":"JA Carbayo","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","DOI":"10.3390\/nu8110680","article-title":"Adherence to the \u201cMediterranean Diet\u201d in Spain and Its Relationship with Cardiovascular Risk (DIMERICA Study)","volume":"8","author":"J Abell\u00e1n Alem\u00e1n","year":"2016","journal-title":"Nutrients"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11906-001-0036-4","article-title":"Serum uric acid as a cardiovascular risk factor for heart disease","volume":"3","author":"MH Alderman","year":"2001","journal-title":"Curr Hypertens Rep"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1464-5491.2004.01239.x","article-title":"Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes","volume":"21","author":"C-H Tseng","year":"2004","journal-title":"Diabet Med"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1093\/rheumatology\/keq184","article-title":"Association between endothelial dysfunction and hyperuricaemia","volume":"49","author":"W-J Ho","year":"2010","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study","volume":"131","author":"BF Culleton","year":"1999","journal-title":"Ann Intern Med"},{"issue":"16","key":"ref22","doi-asserted-by":"crossref","first-page":"e3454","DOI":"10.1097\/MD.0000000000003454","article-title":"A Prediction Model for the Peripheral Arterial Disease Using NHANES Data","volume":"95","author":"Y Zhang","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"e007195","DOI":"10.1136\/bmjopen-2014-007195","article-title":"Validating prediction scales of type 2 diabetes mellitus in Spain: the SPREDIA-2 population-based prospective cohort study protocol","volume":"5","author":"M\u00c1 Salinero-Fort","year":"2015","journal-title":"BMJ Open"},{"issue":"24","key":"ref24","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1161\/CIR.0b013e318276fbcb","article-title":"Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association","volume":"126","author":"V Aboyans","year":"2012","journal-title":"Circulation"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"e43134","DOI":"10.1371\/journal.pone.0043134","article-title":"A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial","volume":"7","author":"MA Mart\u00ednez-Gonz\u00e1lez","year":"2012","journal-title":"PloS One"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3945\/jn.110.135566","article-title":"A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women","volume":"141","author":"H Schr\u00f6der","year":"2011","journal-title":"J Nutr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12966-016-0394-6","article-title":"Predictors of short- and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial","volume":"13","author":"MK Downer","year":"2016","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/ageing\/17.1.57","article-title":"Epidemiology of intermittent claudication: evaluation of risk factors","volume":"17","author":"WE Hale","year":"1988","journal-title":"Age Ageing"},{"issue":"8","key":"ref29","first-page":"726","article-title":"Prevalence and clinical characteristics of peripheral arterial disease in the study population Hermex","volume":"65","author":"FJ F\u00e9lix-Redondo","year":"2012","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"9901","key":"ref30","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"FGR Fowkes","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mehy.2012.11.015","article-title":"Mediterranean diet and the Spanish paradox. A hypothesis","volume":"80","author":"F Soriguer","year":"2013","journal-title":"Med Hypotheses"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1191\/1358863x03vm511oa","article-title":"Ethnic differences in peripheral arterial disease in the NHLBI Genetic Epidemiology Network of Arteriopathy (GENOA) study","volume":"8","author":"IJ Kullo","year":"2003","journal-title":"Vasc Med"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.jvs.2007.02.004","article-title":"A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences","volume":"45","author":"B Sigvant","year":"2007","journal-title":"J Vasc Surg"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.amepre.2005.07.019","article-title":"Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"29","author":"Z-J Zheng","year":"2005","journal-title":"Am J Prev Med"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1708538113476023","article-title":"Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study","volume":"22","author":"JS Hiramoto","year":"2014","journal-title":"Vascular"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/01.CIR.96.7.2468","article-title":"Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Writing Group","volume":"96","author":"L Mosca","year":"1997","journal-title":"Circulation"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/jama.2013.280618","article-title":"Association of Mediterranean diet with peripheral artery disease: the PREDIMED randomized trial","volume":"311","author":"M Ruiz-Canela","year":"2014","journal-title":"JAMA"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.numecd.2014.02.014","article-title":"Decline of the Mediterranean diet at a time of economic crisis. Results from the Moli-sani study","volume":"24","author":"M Bonaccio","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/0003319714566228","article-title":"Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk","volume":"66","author":"Y Zhan","year":"2015","journal-title":"Angiology"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.amjcard.2012.02.061","article-title":"Risk factors for peripheral arterial disease among patients with chronic kidney disease","volume":"110","author":"J Chen","year":"2012","journal-title":"Am J Cardiol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.atherosclerosis.2006.12.029","article-title":"Association between serum uric acid level and peripheral arterial disease","volume":"196","author":"A Shankar","year":"2008","journal-title":"Atherosclerosis"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/eurheartj\/ehi879","article-title":"Uric acid and inflammatory markers","volume":"27","author":"C Ruggiero","year":"2006","journal-title":"Eur Heart J"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.86.9.3375","article-title":"Role of endothelium-derived nitric oxide in the regulation of blood pressure","volume":"86","author":"DD Rees","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/01.mnh.0000199010.33929.7f","article-title":"Hormonal and cytokine effects of uric acid","volume":"15","author":"LG S\u00e1nchez-Lozada","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/j.ajkd.2010.06.004","article-title":"Uric acid, CKD, and cardiovascular disease: confounders, culprits, and circles","volume":"56","author":"N Tangri","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/MNH.0b013e328330d9d0","article-title":"Uric acid: a novel mediator and marker of risk in chronic kidney disease?","volume":"18","author":"DI Feig","year":"2009","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.CIR.100.4.354","article-title":"Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study","volume":"100","author":"SS Franklin","year":"1999","journal-title":"Circulation"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1161\/01.HYP.23.3.395","article-title":"Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction","volume":"23","author":"S Madhavan","year":"1994","journal-title":"Hypertens"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jacc.2015.10.084","article-title":"Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry","volume":"67","author":"S Selvaraj","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.HYP.32.3.560","article-title":"Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects","volume":"32","author":"A Benetos","year":"1998","journal-title":"Hypertens"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.HYP.30.6.1410","article-title":"Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population","volume":"30","author":"A Benetos","year":"1997","journal-title":"Hypertens"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2188\/jea.JE20110140","article-title":"Prevalence of low ankle brachial index and its association with pulse pressure in an elderly Chinese population: a cross-sectional study","volume":"22","author":"Y Zhan","year":"2012","journal-title":"J Epidemiol"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.atherosclerosis.2010.11.015","article-title":"Derivation and validation of REASON: a risk score identifying candidates to screen for peripheral arterial disease using ankle brachial index","volume":"214","author":"R Ramos","year":"2011","journal-title":"Atherosclerosis"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1024\/0301-1526\/a000492","article-title":"Predicting the prevalence of peripheral arterial diseases: modelling and validation in different cohorts","volume":"45","author":"Y Zhan","year":"2016","journal-title":"VASA"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4103\/2319-4170.113371","article-title":"Pulse pressure and Michigan Neuropathy Screening Instrument are independently associated with asymptomatic peripheral arterial disease among type 2 diabetes community residents: a community-based screening program in Taiwan","volume":"36","author":"L-C Fan","year":"2013","journal-title":"Biomed J"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/jhh.2013.99","article-title":"Pulse pressure and subclinical peripheral artery disease","volume":"28","author":"P Korhonen","year":"2014","journal-title":"J Hum Hypertens"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2010.10.011","article-title":"Lower extremity peripheral artery disease in the absence of traditional risk factors. The Multi-Ethnic Study of Atherosclerosis","volume":"214","author":"V Aboyans","year":"2011","journal-title":"Atherosclerosis"},{"issue":"7","key":"ref58","first-page":"241","article-title":"Value of the ankle-brachial index in cardiovascular risk stratification of patients without known atherotrombotic disease. MERITO study","volume":"128","author":"L Manzano","year":"2007","journal-title":"Med Clin (Barc)"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/euhj.1999.1741","article-title":"The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study)","volume":"21","author":"E Kristal-Boneh","year":"2000","journal-title":"Eur Heart J"},{"issue":"9","key":"ref60","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/oxfordjournals.aje.a009901","article-title":"Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry","volume":"149","author":"P Greenland","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"8","key":"ref61","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/heartjnl-2014-306472","article-title":"Cardiovascular risk profile and frailty in a population-based study of older British men","volume":"101","author":"SE Ramsay","year":"2015","journal-title":"Heart"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"M158","DOI":"10.1093\/gerona\/56.3.M158","article-title":"Associations of subclinical cardiovascular disease with frailty","volume":"56","author":"AB Newman","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1067\/mhj.2002.122871","article-title":"Wilson PW f. Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study","volume":"143","author":"JM Murabito","year":"2002","journal-title":"Am Heart J"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/oxfordjournals.aje.a116709","article-title":"Prevalence and correlates of lower extremity arterial disease in elderly women","volume":"137","author":"MT Vogt","year":"1993","journal-title":"Am J Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T02:15:31Z","timestamp":1570241731000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186220"}},"subtitle":[],"editor":[{"given":"Xianwu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186220","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}