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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/influenza\/human_animal_interface\/H5N1_cumulative_table_archives\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/influenza\/human_animal_interface\/H5N1_cumulative_table_archives\/en\/<\/ext-link>."},{"issue":"20","key":"ref4","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"R Gao","year":"2013","journal-title":"N Engl J Med"},{"key":"ref5","unstructured":"FAO H7N9 situation update\u2014Avian Influenza A(H7N9) virus\u2014FAO Emergency Prevention System for Animal Health (EMPRES-AH) 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fao.org\/ag\/againfo\/programmes\/en\/empres\/h7n9\/situation_update.html\" xlink:type=\"simple\">http:\/\/www.fao.org\/ag\/againfo\/programmes\/en\/empres\/h7n9\/situation_update.html<\/ext-link>."},{"issue":"7468","key":"ref6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature12476","article-title":"Limited airborne transmission of H7N9 influenza A virus between ferrets","volume":"501","author":"M Richard","year":"2013","journal-title":"Nature"},{"issue":"6142","key":"ref7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.1239844","article-title":"Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs","volume":"341","author":"H Zhu","year":"2013","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"f4752","DOI":"10.1136\/bmj.f4752","article-title":"Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation","volume":"347","author":"X Qi","year":"2013","journal-title":"BMJ"},{"issue":"6163","key":"ref9","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1243761","article-title":"Preferential recognition of avian-like receptors in human influenza A H7N9 viruses","volume":"342","author":"R Xu","year":"2013","journal-title":"Science"},{"key":"ref10","unstructured":"WHO | Avian and other zoonotic influenza: World Health Organization; 2017 [updated 2017-09-08 13:05:31]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/influenza\/human_animal_interface\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/influenza\/human_animal_interface\/en\/<\/ext-link>."},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1073\/pnas.0308352100","article-title":"Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome","volume":"101","author":"RA Fouchier","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9182","key":"ref12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0140-6736(99)03311-5","article-title":"Human infection with influenza H9N2","volume":"354","author":"M Peiris","year":"1999","journal-title":"Lancet"},{"issue":"2","key":"ref13","first-page":"105","article-title":"Discovery of men infected by avian influenza A (H9N2) 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