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CDC Opiod Prescribing Guideline Call: HHS.gov; 2016 [cited 2016 May 6, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.hhs.gov\/about\/leadership\/secretary\/speeches\/2016\/cdc-opioid-prescribing-guideline-call.html\" xlink:type=\"simple\">http:\/\/www.hhs.gov\/about\/leadership\/secretary\/speeches\/2016\/cdc-opioid-prescribing-guideline-call.html<\/ext-link>."},{"key":"ref2","unstructured":"Association AP. Opioid Use Disorder\u2014Diagnostic Criteria. In: Association AP, editor. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Fifth ed. 1\u201392013. p. 1\u20139."},{"key":"ref3","unstructured":"Katz J. Drug deaths in American are rising fasteer than ever New York City: The New York Times Company; 2017 [cited 2017 07\/25\/2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.nytimes.com\/interactive\/2017\/06\/05\/upshot\/opioid-epidemic-drug-overdose-deaths-are-rising-faster-than-ever.html\" xlink:type=\"simple\">https:\/\/www.nytimes.com\/interactive\/2017\/06\/05\/upshot\/opioid-epidemic-drug-overdose-deaths-are-rising-faster-than-ever.html<\/ext-link>"},{"key":"ref4","unstructured":"Crime UNOoDa. World Drug Report 2015."},{"issue":"50\u201351","key":"ref5","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15585\/mmwr.mm6450a3","article-title":"Increases in Drug and Opioid Overdose Deaths\u2014United States, 2000\u20132014","volume":"64","author":"RA Rudd","year":"2016","journal-title":"MMWR Morbidity and mortality weekly report"},{"key":"ref6","unstructured":"Policy OoNDC. Medication-Assisted Treatment for Opiod Addiction. Executive Office of the President; 2012."},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1521-0391.2013.12049.x","article-title":"Community-based treatment for opioid dependent offenders: A pilot study","volume":"22","author":"R Brown","year":"2013","journal-title":"American Journal on Addictions"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/apc.2013.0179","article-title":"Patient Perspectives of an Integrated Program of Medical Care and Substance Use Treatment","volume":"28","author":"M-L Drainoni","year":"2014","journal-title":"AIDS Patient Care & STDs"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11524-014-9924-1","article-title":"Buprenorphine maintenance treatment retention improves nationally recommended preventive primary care screenings when integrated into urban federally qualified health centers","volume":"92","author":"MS Haddad","year":"2015","journal-title":"Journal of urban health: bulletin of the New York Academy of Medicine"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.7326\/0003-4819-152-11-201006010-00003","article-title":"Clinic-based treatment of opioid-dependent HIV-infected patients versus referral to an opioid treatment program: A randomized trial","volume":"152","author":"GM Lucas","year":"2010","journal-title":"Annals of internal medicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jsat.2015.07.007","article-title":"Engagement and Substance Dependence in a Primary Care-Based Addiction Treatment Program for People Infected with HIV and People at High-Risk for HIV Infection","volume":"59","author":"AY Walley","year":"2015","journal-title":"J Subst Abuse Treat"},{"issue":"Suppl 1","key":"ref12","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/QAI.0b013e3182097426","article-title":"The BHIVES 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American journal of psychiatry"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11606-006-0023-1","article-title":"Treating homeless opioid dependent patients with buprenorphine in an office-based setting","volume":"22","author":"DP Alford","year":"2007","journal-title":"Journal of General Internal Medicine"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archinternmed.2010.541","article-title":"Collaborative care of opioid-addicted patients in primary care using buprenorphine: five-year experience","volume":"171","author":"DP Alford","year":"2011","journal-title":"Archives of Internal Medicine"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1300\/J069v24n02_03","article-title":"Opiate dependence treatment with buprenorphine: one year&apos;s experience in a family practice residency setting","volume":"24","author":"S Colameco","year":"2005","journal-title":"J 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Therapeutic efficacy and predictors of clinical response","volume":"10","author":"A Michelazzi","year":"2008","journal-title":"Heroin Addiction and Related Clinical Problems"},{"issue":"Suppl 1","key":"ref77","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1097\/QAI.0b013e31820a8226","article-title":"Integration of buprenorphine\/naloxone treatment into HIV clinical care: lessons from the BHIVES collaborative","volume":"56","author":"L Weiss","year":"2011","journal-title":"Journal of acquired immune deficiency syndromes"},{"issue":"3","key":"ref78","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/ADT.0b013e31805dad80","article-title":"Lessons learned in OBOT: 3 case studies of women who did not succeed in pharmacy-based methadone treatment","volume":"7","author":"E Tuchman","year":"2008","journal-title":"Addictive Disorders & Their Treatment"},{"key":"ref79","first-page":"281","article-title":"Buprenorphine: New treatment of opioid addiction in primary care","volume":"57","author":"M Kahan","year":"2011","journal-title":"Canadian Family Physician"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"74.e11","DOI":"10.1016\/j.amjmed.2012.07.005","article-title":"A randomized trial of cognitive behavioral therapy in primary care-based buprenorphine","volume":"126","author":"DA Fiellin","year":"2013","journal-title":"Am J Med"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/ADM.0b013e3182596492","article-title":"Counseling and directly observed medication for primary care buprenorphine maintenance: a pilot study","volume":"6","author":"BA Moore","year":"2012","journal-title":"J Addict Med"},{"issue":"Suppl 1","key":"ref82","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/QAI.0b013e3182097537","article-title":"Drug treatment outcomes among HIV-infected opioid-dependent patients receiving buprenorphine\/naloxone","volume":"56","author":"DA Fiellin","year":"2011","journal-title":"Journal of acquired immune deficiency syndromes"},{"issue":"Suppl 1","key":"ref83","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1080\/10550490490440843","article-title":"Processes of care during a randomized trial of office-based treatment of opioid dependence in primary care","volume":"13","author":"DA Fiellin","year":"2004","journal-title":"Am J Addict"},{"issue":"3","key":"ref84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1300\/J126v02n03_03","article-title":"Initiating office based prescribing of methadone: experience of primary care providers in New York City","volume":"2","author":"K Bonuck","year":"2003","journal-title":"Journal of Maintenance in the Addictions"},{"issue":"1","key":"ref85","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/08897077.2015.1129388","article-title":"Project ECHO (Extension for Community Healthcare Outcomes): A new model for educating primary care providers about treatment of substance use disorders","volume":"37","author":"M Komaromy","year":"2016","journal-title":"Subst Abus"},{"issue":"5","key":"ref86","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archinternmed.2010.541","article-title":"Collaborative care of opioid-addicted patients in primary care using buprenorphine: five-year experience","volume":"171","author":"DP Alford","year":"2011","journal-title":"Arch Intern Med"},{"issue":"12","key":"ref87","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1001\/jamainternmed.2014.5302","article-title":"Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial","volume":"174","author":"DA Fiellin","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"11","key":"ref88","doi-asserted-by":"crossref","first-page":"712","DOI":"10.7326\/0003-4819-152-11-201006010-00004","article-title":"Systematic review: treatment agreements and urine drug testing to reduce opioid misuse in patients with chronic pain","volume":"152","author":"JL Starrels","year":"2010","journal-title":"Annals of internal medicine"},{"key":"ref89","doi-asserted-by":"crossref","DOI":"10.1186\/s13011-015-0009-2","article-title":"Implementing buprenorphine in addiction treatment: Payer and provider perspectives in Ohio","volume":"10","author":"T Molfenter","year":"2015","journal-title":"Substance Abuse Treatment, Prevention, and Policy"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.addbeh.2011.01.004","article-title":"Consumer and treatment provider perspectives on reducing barriers to opioid substitution treatment and improving treatment attractiveness","volume":"36","author":"DEA Deering","year":"2011","journal-title":"Addictive Behaviors"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1747-597X-8-26","article-title":"Structural barriers in the context of opiate substitution treatment in Germany\u2014a survey among physicians in primary care","volume":"8","author":"B Schulte","year":"2013","journal-title":"Subst Abuse Treat Prev Policy"},{"key":"ref92","unstructured":"PCSSMAT. PCSSMAT PCSS-MAT <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/pcssmat.org\/\" xlink:type=\"simple\">http:\/\/pcssmat.org\/<\/ext-link>) PCSSO Training; [cited 2016]."},{"key":"ref93","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2147\/SAR.S69715","article-title":"Primary care for opioid use disorder","volume":"7","author":"P Mannelli","year":"2016","journal-title":"Substance abuse and rehabilitation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:28:50Z","timestamp":1540340930000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186315"}},"subtitle":[],"editor":[{"given":"Tina","family":"Hernandez-Boussard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":93,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186315","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}