{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:27Z","timestamp":1761823947203,"version":"3.37.3"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186349","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T13:41:34Z","timestamp":1508247694000},"page":"e0186349","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decreased NK cell immunity in kidney transplant recipients late post-transplant and increased NK-cell immunity in patients with recurrent miscarriage"],"prefix":"10.1371","volume":"12","author":[{"given":"Li","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Aly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristos","family":"Karakizlis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Weimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Morath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben Jeremias","family":"Kuon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Opelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-1031","authenticated-orcid":true,"given":"Volker","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1681\/ASN.2007040423","article-title":"Frontiers in nephrology: the varied faces of natural killer cells in transplantation\u2014contributions to both allograft immunity and tolerance","volume":"18","author":"JN Beilke","year":"2007","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"8","key":"ref2","first-page":"2845","article-title":"Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients","volume":"118","author":"M Martinez-Llordella","year":"2008","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/j.1600-6143.2011.03928.x","article-title":"A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation","volume":"12","author":"L Li","year":"2012","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1172\/JCI39922","article-title":"Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans","volume":"120","author":"P Sagoo","year":"2010","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1172\/JCI59411","article-title":"Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation","volume":"122","author":"F Bohne","year":"2012","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s12026-015-8766-6","article-title":"Unexplained post-renal transplant tolerance: a case report","volume":"64","author":"S Kesiraju","year":"2016","journal-title":"Immunologic research"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cei.12945","article-title":"Association of peripheral NK cell counts with Helios+ IFN-gamma- Tregs in patients with good long-term renal allograft function","volume":"188","author":"K Trojan","year":"2017","journal-title":"Clinical and experimental immunology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4049\/jimmunol.180.2.850","article-title":"Regulatory NK cells suppress antigen-specific T cell responses","volume":"180","author":"G Deniz","year":"2008","journal-title":"Journal of immunology"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00281-016-0574-0","article-title":"The decidua-the maternal bed embracing the embryo-maintains the pregnancy","volume":"38","author":"M Mori","year":"2016","journal-title":"Seminars in immunopathology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2016.00262","article-title":"Human Circulating and Tissue-Resident CD56(bright) Natural Killer Cell Populations","volume":"7","author":"JE Melsen","year":"2016","journal-title":"Frontiers in immunology"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00441-015-2315-4","article-title":"To serve and to protect: the role of decidual innate immune cells on human pregnancy","volume":"363","author":"J Zhang","year":"2016","journal-title":"Cell and tissue research"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12016-009-8184-4","article-title":"NK cells, autoantibodies, and immunologic infertility: a complex interplay","volume":"39","author":"C De Carolis","year":"2010","journal-title":"Clinical reviews in allergy & immunology"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/rheumatology\/kem197","article-title":"High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis","volume":"46","author":"C Perricone","year":"2007","journal-title":"Rheumatology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.fertnstert.2007.02.012","article-title":"Intracellular cytokine expression of peripheral blood natural killer cell subsets in women with recurrent spontaneous abortions and implantation failures","volume":"89","author":"A Fukui","year":"2008","journal-title":"Fertility and sterility"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jri.2016.11.002","article-title":"The &quot;killer cell story&quot; in recurrent miscarriage: Association between activated peripheral lymphocytes and uterine natural killer cells","volume":"119","author":"RJ Kuon","year":"2017","journal-title":"Journal of reproductive immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","article-title":"Biology of natural killer cells","volume":"47","author":"G Trinchieri","year":"1989","journal-title":"Advances in immunology"},{"issue":"4","key":"ref17","first-page":"212","article-title":"Natural Killer Cell Subsets and IL-2, IL-15, and IL-18 Genes Expressions in Chronic Kidney Allograft Dysfunction and Graft Function in Kidney Allograft Recipients","volume":"7","author":"S Assadiasl","year":"2016","journal-title":"International journal of organ transplantation medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fimmu.2016.00288","article-title":"Antibody-Dependent NK Cell Activation Is Associated with Late Kidney Allograft Dysfunction and the Complement-Independent Alloreactive Potential of Donor-Specific Antibodies","volume":"7","author":"T Legris","year":"2016","journal-title":"Frontiers in immunology"},{"key":"ref19","article-title":"Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: associations with microcirculation injuries and graft survival","author":"DC Dos Santos","year":"2016","journal-title":"Nephrology"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/MOT.0000000000000193","article-title":"The molecular phenotypes of rejection in kidney transplant biopsies","volume":"20","author":"PF Halloran","year":"2015","journal-title":"Current opinion in organ transplantation"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/ajt.13115","article-title":"The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors","volume":"15","author":"JM Venner","year":"2015","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1097\/TP.0000000000000792","article-title":"Natural Killer Lymphocytes Are Dysfunctional in Kidney Transplant Recipients on Diagnosis of Cancer","volume":"99","author":"MN Peraldi","year":"2015","journal-title":"Transplantation"},{"issue":"23","key":"ref23","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1182\/blood-2012-08-453738","article-title":"LAMP1\/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity","volume":"121","author":"K Krzewski","year":"2013","journal-title":"Blood"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/1521-4141(200202)32:2<413::AID-IMMU413>3.0.CO;2-X","article-title":"Distinction between IL-13+ and IFN-gamma+ natural killer cells and regulation of their pool size by IL-4","volume":"32","author":"MJ Loza","year":"2002","journal-title":"European journal of immunology"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.imbio.2014.11.015","article-title":"Accentuated hypo- and hyper-NK lymphocyte CD8 expression is a marker of NK subsets&apos; misbalance and is predictive for reproductive failures","volume":"220","author":"BV Dons'koi","year":"2015","journal-title":"Immunobiology"},{"issue":"21","key":"ref26","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1128\/JVI.01420-14","article-title":"High frequencies of polyfunctional CD8+ NK cells in chronic HIV-1 infection are associated with slower disease progression","volume":"88","author":"F Ahmad","year":"2014","journal-title":"Journal of virology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molimm.2004.07.017","article-title":"Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell","volume":"42","author":"B Perussia","year":"2005","journal-title":"Molecular immunology"},{"issue":"1\u20132","key":"ref28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cellimm.2015.09.002","article-title":"Peripheral blood NK cells expressing HLA-G, IL-10 and TGF-beta in healthy donors and breast cancer patients","volume":"298","author":"YO Ostapchuk","year":"2015","journal-title":"Cellular immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jri.2015.05.001","article-title":"Characterization of the subsets of human NKT-like cells and the expression of Th1\/Th2 cytokines in patients with unexplained recurrent spontaneous abortion","volume":"110","author":"J Yuan","year":"2015","journal-title":"Journal of reproductive immunology"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/imm.12224","article-title":"Subsets of human natural killer cells and their regulatory effects","volume":"141","author":"B Fu","year":"2014","journal-title":"Immunology"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jri.2007.04.007","article-title":"The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy","volume":"77","author":"S Saito","year":"2008","journal-title":"Journal of reproductive immunology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00281-007-0067-2","article-title":"Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance","volume":"29","author":"S Saito","year":"2007","journal-title":"Seminars in immunopathology"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jaut.2012.05.006","article-title":"Regulatory NK cells in autoimmune disease","volume":"39","author":"Z Tian","year":"2012","journal-title":"Journal of autoimmunity"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7150\/jca.5519","article-title":"Dual functions of natural killer cells in selection and differentiation of stem cells; role in regulation of inflammation and regeneration of tissues","volume":"4","author":"A Jewett","year":"2013","journal-title":"Journal of Cancer"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/cei.12580","article-title":"Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis","volume":"180","author":"E Rodriguez-Martin","year":"2015","journal-title":"Clinical and experimental immunology"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.4049\/jimmunol.174.9.5187","article-title":"Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis","volume":"174","author":"Z Li","year":"2005","journal-title":"Journal of immunology"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"e0132484","DOI":"10.1371\/journal.pone.0132484","article-title":"NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging","volume":"10","author":"U Hoffmann","year":"2015","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:11:25Z","timestamp":1540257085000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186349"}},"subtitle":[],"editor":[{"given":"Golo","family":"Ahlenstiel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186349","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}