{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:12:36Z","timestamp":1762542756236,"version":"3.37.3"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273265"],"award-info":[{"award-number":["81273265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572562"],"award-info":[{"award-number":["81572562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Science and Technology Project Foundation","award":["2013FJ2005"],"award-info":[{"award-number":["2013FJ2005"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186409","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T17:30:15Z","timestamp":1507915815000},"page":"e0186409","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphism of keratin 1 associates with systemic lupus erythematosus and systemic sclerosis in a south Chinese population"],"prefix":"10.1371","volume":"12","author":[{"given":"Weiguang","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-1161","authenticated-orcid":true,"given":"Yizhou","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1074-7613(01)00201-1","article-title":"Delineating the genetic basis of systemic lupus erythematosus","volume":"15","author":"EK Wakeland","year":"2001","journal-title":"IMMUNITY"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/08916930601061363","article-title":"Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function","volume":"39","author":"VC Kyttaris","year":"2006","journal-title":"AUTOIMMUNITY"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"J Varga","year":"2007","journal-title":"J CLIN INVEST"},{"issue":"19","key":"ref4","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"A Gabrielli","year":"2009","journal-title":"N Engl J Med"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus","volume":"41","author":"JW Han","year":"2009","journal-title":"NAT GENET"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/ddp118","article-title":"ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai","volume":"18","author":"W Yang","year":"2009","journal-title":"HUM MOL GENET"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"e1000841","DOI":"10.1371\/journal.pgen.1000841","article-title":"Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus","volume":"6","author":"W Yang","year":"2010","journal-title":"PLOS GENET"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ajhg.2012.11.018","article-title":"Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians","volume":"92","author":"W Yang","year":"2013","journal-title":"AM J HUM GENET"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","article-title":"Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis","volume":"94","author":"MD Mayes","year":"2014","journal-title":"AM J HUM GENET"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1469-7580.2009.01066.x","article-title":"Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia","volume":"214","author":"HH Bragulla","year":"2009","journal-title":"J ANAT"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.200603161","article-title":"New consensus nomenclature for mammalian keratins","volume":"174","author":"J Schweizer","year":"2006","journal-title":"The Journal of Cell Biology"},{"issue":"15","key":"ref12","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1016\/S0021-9258(19)38954-9","article-title":"The two-chain coiled-coil molecule of native epidermal keratin intermediate filaments is a type I-type II heterodimer","volume":"265","author":"PM Steinert","year":"1990","journal-title":"J BIOL CHEM"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0625.2008.00775.x","article-title":"Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes","volume":"18","author":"L Micallef","year":"2009","journal-title":"EXP DERMATOL"},{"issue":"2 Pt 1","key":"ref14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1083\/jcb.95.2.580","article-title":"Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies","volume":"95","author":"J Woodcock-Mitchell","year":"1982","journal-title":"J CELL BIOL"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.yexcr.2007.04.023","article-title":"Intermediate filaments and stress","volume":"313","author":"M Pekny","year":"2007","journal-title":"EXP CELL RES"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1182\/blood.V97.8.2342","article-title":"Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells","volume":"97","author":"F Mahdi","year":"2001","journal-title":"BLOOD"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1073\/pnas.95.7.3615","article-title":"Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells","volume":"95","author":"AA Hasan","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11 Pt A","key":"ref18","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1016\/j.bbamcr.2015.09.002","article-title":"New insights into circulating FABP4: Interaction with cytokeratin 1 on endothelial cell membranes","volume":"1853","author":"P Saavedra","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"e697","DOI":"10.1371\/journal.pone.0000697","article-title":"In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval","volume":"2","author":"H Tao","year":"2007","journal-title":"PLOS ONE"},{"issue":"Pt 22","key":"ref20","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1242\/jcs.116574","article-title":"Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18","volume":"125","author":"W Roth","year":"2012","journal-title":"J CELL SCI"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2133.2010.10096.x","article-title":"Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis","volume":"164","author":"MJ Arin","year":"2011","journal-title":"Br J Dermatol"},{"issue":"20","key":"ref22","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1056\/NEJMra040319","article-title":"Intermediate filament proteins and their associated diseases","volume":"351","author":"MB Omary","year":"2004","journal-title":"N Engl J Med"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrrheum.2015.106","article-title":"Pathogenesis and targeted treatment of skin injury in SLE","volume":"11","author":"GM Deng","year":"2015","journal-title":"NAT REV RHEUMATOL"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/art.39287","article-title":"A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis","volume":"67","author":"LM Rice","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.humimm.2013.05.003","article-title":"Alleles of keratin 1 in families and populations","volume":"74","author":"M Han","year":"2013","journal-title":"HUM IMMUNOL"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"F van den Hoogen","year":"2013","journal-title":"ANN RHEUM DIS"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"F van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref28","first-page":"47","article-title":"Arlequin (version 3.0): An integrated software package for population genetics data analysis","volume":"1","author":"L Excoffier","year":"2005","journal-title":"Evolutionary Bioinformatics Online"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1111\/j.1360-0443.2009.02697.x","article-title":"Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence","volume":"104","author":"L Chen","year":"2009","journal-title":"Addiction (Abingdon, England)"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0197-2456(90)90005-M","article-title":"Power and sample size calculations. A review and computer program","volume":"11","author":"WD Dupont","year":"1990","journal-title":"Control Clin Trials"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/1523-1747.ep12614149","article-title":"The two size alleles of human keratin 1 are due to a deletion in the glycine-rich carboxyl-terminal V2 subdomain","volume":"99","author":"BP Korge","year":"1992","journal-title":"J INVEST DERMATOL"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ng.565","article-title":"Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus","volume":"42","author":"TR Radstake","year":"2010","journal-title":"NAT GENET"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"e1002091","DOI":"10.1371\/journal.pgen.1002091","article-title":"Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis","volume":"7","author":"Y Allanore","year":"2011","journal-title":"PLOS GENET"},{"issue":"6","key":"ref34","first-page":"e127957","article-title":"Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis","volume":"10","author":"Y Chen","year":"2015","journal-title":"PLOS ONE"},{"issue":"41","key":"ref35","doi-asserted-by":"crossref","first-page":"E6162","DOI":"10.1073\/pnas.1606996113","article-title":"Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function","volume":"113","author":"SK Ippagunta","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/BOR.0000000000000411","article-title":"Genetic advances in systemic lupus erythematosus: an update","volume":"29","author":"L Chen","year":"2017","journal-title":"CURR OPIN RHEUMATOL"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/BOR.0000000000000214","article-title":"Genetics of systemic sclerosis: recent advances","volume":"27","author":"PS Ramos","year":"2015","journal-title":"CURR OPIN RHEUMATOL"},{"issue":"20","key":"ref38","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1128\/JVI.00770-09","article-title":"Activation of MDA5 requires higher-order RNA structures generated during virus infection","volume":"83","author":"A Pichlmair","year":"2009","journal-title":"J VIROL"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ng.2933","article-title":"Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling","volume":"46","author":"GI Rice","year":"2014","journal-title":"NAT GENET"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/hmg\/ddn342","article-title":"IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells","volume":"18","author":"S Liu","year":"2009","journal-title":"HUM MOL GENET"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"A Strange","year":"2010","journal-title":"NAT GENET"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajhg.2014.06.007","article-title":"Aicardi-Goutieres syndrome is caused by IFIH1 mutations","volume":"95","author":"H Oda","year":"2014","journal-title":"AM J HUM GENET"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.20021553","article-title":"Interferon and granulopoiesis signatures in systemic lupus erythematosus blood","volume":"197","author":"L Bennett","year":"2003","journal-title":"J EXP MED"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"EC Baechler","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"e1002341","DOI":"10.1371\/journal.pgen.1002341","article-title":"Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus","volume":"7","author":"GD Cunninghame","year":"2011","journal-title":"PLOS GENET"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/art.39110","article-title":"Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency","volume":"67","author":"L Van Eyck","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/08916930600739233","article-title":"Complement deficiencies in humans and animals: links to autoimmunity","volume":"39","author":"MJ Lewis","year":"2006","journal-title":"AUTOIMMUNITY"},{"key":"ref48","article-title":"Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease","author":"E Demirkaya","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1101\/gr.4559106","article-title":"Analysis of allelic differential expression in human white blood cells","volume":"16","author":"PV Pant","year":"2006","journal-title":"GENOME RES"},{"issue":"Pt 7","key":"ref50","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1242\/jcs.097139","article-title":"Deletion of K1\/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity","volume":"125","author":"L Wallace","year":"2012","journal-title":"J CELL SCI"},{"key":"ref51","first-page":"8679841","article-title":"Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies","volume":"2017","author":"X Guo","year":"2017","journal-title":"J Immunol Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T15:59:00Z","timestamp":1659628740000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186409"}},"subtitle":[],"editor":[{"given":"Tao","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,13]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186409","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,10,13]]}}}