{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:43:00Z","timestamp":1778481780528,"version":"3.51.4"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186424","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T17:46:04Z","timestamp":1508435164000},"page":"e0186424","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["The prevalence of human papillomavirus in oropharyngeal cancer in a New Zealand population"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-3935","authenticated-orcid":true,"given":"Rebecca","family":"Lucas-Roxburgh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Benschop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Lockett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"van den Heever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laryssa","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"ref1","first-page":"1429","article-title":"Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?","author":"EM Sturgis","year":"2007","journal-title":"J.B. Lippincott Company"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12105-009-0100-y","article-title":"The changing face of head and neck cancer in the 21st century: the impact of HPV on the epidemiology and pathology of oral cancer","volume":"3","author":"WH Westra","year":"2009","journal-title":"Head Neck Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic","author":"S Marur","year":"2010","journal-title":"Lancet Oncology"},{"key":"ref4","article-title":"The "New" Head and Neck Cancer Patient-Young, Nonsmoker, Nondrinker, and HPV Positive: Evaluation","author":"DG Deschler","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.anndiagpath.2011.07.003","article-title":"Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma","volume":"16","author":"XI Wang","year":"2012","journal-title":"Ann Diagn Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.vaccine.2006.05.115","article-title":"Chapter 1: HPV in the etiology of human cancer","volume":"24","author":"N Mu\u00f1oz","year":"2006","journal-title":"Vaccine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ijc.28201","article-title":"Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix","volume":"134","author":"ML Gillison","year":"2014","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1471-2407-13-220","article-title":"Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population","volume":"13","author":"M Evans","year":"2013","journal-title":"BMC Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1158\/1078-0432.CCR-11-0388","article-title":"Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination","volume":"17","author":"AG Schache","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jcp.2010.088450","article-title":"Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice","volume":"64","author":"S Thavaraj","year":"2011","journal-title":"J Clin Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ijc.11633","article-title":"Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers","volume":"108","author":"EM Smith","year":"2004","journal-title":"Int J Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.humpath.2011.03.009","article-title":"Incidence of human papillomavirus in oropharyngeal squamous cell carcinomas: now and 50 years ago","volume":"43","author":"J Chenevert","year":"2012","journal-title":"Hum Pathol"},{"issue":"Suppl 1","key":"ref13","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1007\/s12105-012-0377-0","article-title":"Epidemiology and clinical aspects of HPV in head and neck cancers","volume":"6","author":"AK Chaturvedi","year":"2012","journal-title":"Head Neck Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"ML Gillison","year":"2008","journal-title":"JNCI: Journal of the National Cancer Institute"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1080\/01635581.2011.570894","article-title":"Higher Micronutrient Intake Is Associated With Human Papillomavirus-Positive Head and Neck Cancer: A Case-Only Analysis","volume":"63","author":"AE Arthur","year":"2011","journal-title":"Nutrition & Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canep.2013.12.004","article-title":"Comparison of oropharyngeal and oral cavity squamous cell cancer incidence and trends in New Zealand and Queensland, Australia","volume":"38","author":"JM Elwood","year":"2014","journal-title":"Cancer Epidemiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.2448875","article-title":"Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase","author":"RK Saiki","year":"1988","journal-title":"The American Association for the Advancement of Science"},{"issue":"Pt 4","key":"ref18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1099\/0022-1317-76-4-1057","article-title":"The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR","volume":"76","author":"AM de Roda Husman","year":"1995","journal-title":"The Journal Of General Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-9378-6-1","article-title":"Single-tube multiplex PCR using type-specific E6\/E7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia","volume":"6","author":"M Dictor","year":"2011","journal-title":"Infect Agent Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"Journal of Molecular Biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/ijc.27821","article-title":"Increasing prevalence rates of HPV attributable oropharyngeal squamous cell carcinomas in the Netherlands as assessed by a validated test algorithm","volume":"132","author":"MM Rietbergen","year":"2013","journal-title":"Int J Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ijc.24339","article-title":"Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?","volume":"125","author":"A Nasman","year":"2009","journal-title":"Int J Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"AK Chaturvedi","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bjoms.2016.05.033","article-title":"Changing prevalence and treatment outcomes of patients with p16 human papillomavirus related oropharyngeal squamous cell carcinoma in New Zealand","volume":"54","author":"HJ Kwon","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/modpathol.2011.91","article-title":"A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer","volume":"24","author":"NF Schlecht","year":"2011","journal-title":"Mod Pathol"},{"issue":"Suppl 1","key":"ref26","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1007\/s12105-012-0369-0","article-title":"p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma","volume":"6","author":"JS Lewis Jr.","year":"2012","journal-title":"Head Neck Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/cncr.25033","article-title":"Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience","volume":"116","author":"AD Singhi","year":"2010","journal-title":"Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1200\/JCO.2004.00.3335","article-title":"Molecular classification identifies a subset of human papillomavirus\u2014associated oropharyngeal cancers with favorable prognosis","volume":"24","author":"PM Weinberger","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/bjc.2011.542","article-title":"Benefit of chemotherapy as part of treatment for HPV DNA-positive but p16-negative squamous cell carcinoma of the oropharynx","volume":"106","author":"E Junor","year":"2012","journal-title":"British Journal of Cancer"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2014.05.004","article-title":"Detection of human papillomavirus (HPV) in clinical samples: Evolving methods and strategies for the accurate determination of HPV status of head and neck carcinomas","author":"WH Westra","year":"2014","journal-title":"Oral Oncology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/hed.23034","article-title":"Viral load, physical status, and E6\/E7 mRNA expression of human papillomavirus in head and neck squamous cell carcinoma","volume":"35","author":"Z Deng","year":"2013","journal-title":"Head & Neck"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.humpath.2011.05.010","article-title":"The relationship between p16 expression and high-risk human papillomavirus infection in squamous cell carcinomas from sites other than uterine cervix: a study of 137 cases","volume":"43","author":"EE Doxtader","year":"2012","journal-title":"Hum Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s12105-012-0382-3","article-title":"Equivocal p16 immunostaining in squamous cell carcinoma of the head and neck: staining patterns are suggestive of HPV status","volume":"6","author":"ZW Chen","year":"2012","journal-title":"Head Neck Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/modpathol.2012.79","article-title":"Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status","volume":"25","author":"JS Lewis Jr.","year":"2012","journal-title":"Mod Pathol"},{"key":"ref35","unstructured":"Kreimer AR, Clifford GM, Boyle P, Franceschi S Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1405044","article-title":"A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women","volume":"372","author":"EA Joura","year":"2015","journal-title":"N Engl J Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T22:00:16Z","timestamp":1719525616000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186424"}},"subtitle":[],"editor":[{"given":"Maria Lina","family":"Tornesello","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186424","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}