{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:54:51Z","timestamp":1782284091430,"version":"3.54.5"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270280"],"award-info":[{"award-number":["81270280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2016CFB445"],"award-info":[{"award-number":["2016CFB445"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186635","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T14:08:52Z","timestamp":1508854132000},"page":"e0186635","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis"],"prefix":"10.1371","volume":"12","author":[{"given":"Liming","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-5191","authenticated-orcid":true,"given":"Junming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"ref1","article-title":"Physiological and pathological cardiac hypertrophy","author":"I Shimizu","year":"2016","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"BJ Maron","year":"2013","journal-title":"The Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/01.hjh.0000388492.73954.0b","article-title":"Novel regulators and drug targets of cardiac hypertrophy","volume":"28","author":"P Finckenberg","year":"2010","journal-title":"Journal of hypertension"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCRESAHA.110.225888","article-title":"TRPC channels as effectors of cardiac hypertrophy","volume":"108","author":"P Eder","year":"2011","journal-title":"Circulation research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca 2+\/calmodulin\u2013dependent kinase II in the transition from pressure overload\u2013induced cardiac hypertrophy to heart failure in mice","volume":"119","author":"H Ling","year":"2009","journal-title":"The Journal of clinical investigation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","article-title":"Molecular pathways underlying cardiac remodeling during pathophysiological stimulation","volume":"122","author":"I Kehat","year":"2010","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1073\/pnas.94.14.7543","article-title":"Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload","volume":"94","author":"TC Herzig","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.01.013","article-title":"Fibroblast-mediated pathways in cardiac hypertrophy","volume":"70","author":"K Fujiu","year":"2014","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1096\/fj.09-146589","article-title":"Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension","volume":"24","author":"Y Oishi","year":"2010","journal-title":"The FASEB Journal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbamcr.2014.12.001","article-title":"Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression","volume":"1853","author":"X Song","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.yjmcc.2007.07.046","article-title":"Overt expression of AP-1 reduces alpha myosin heavy chain expression and contributes to heart failure from chronic volume overload","volume":"43","author":"G Freire","year":"2007","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1101\/gr.121749.111","article-title":"Coevolution of retroelements and tandem zinc finger genes","volume":"21","author":"JH Thomas","year":"2011","journal-title":"Genome research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e23747","DOI":"10.1371\/journal.pone.0023747","article-title":"MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression","volume":"6","author":"TZ Xiao","year":"2011","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e21553","DOI":"10.1371\/journal.pone.0021553","article-title":"Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species","volume":"6","author":"K Nowick","year":"2011","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-007-9674-4","article-title":"ZNF418, a novel human KRAB\/C2H2 zinc finger protein, suppresses MAPK signaling pathway","volume":"310","author":"Y Li","year":"2008","journal-title":"Molecular and cellular biochemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"E Shaulian","year":"2002","journal-title":"Nature cell biology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"H282","DOI":"10.1152\/ajpheart.00231.2012","article-title":"Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18","volume":"303","author":"AJ Valente","year":"2012","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11010-012-1341-8","article-title":"Guanylyl cyclase\/natriuretic peptide receptor-A signaling antagonizes the vascular endothelial growth factor-stimulated MAPKs and downstream effectors AP-1 and CREB in mouse mesangial cells","volume":"368","author":"S Tripathi","year":"2012","journal-title":"Molecular and cellular biochemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00424-006-0180-4","article-title":"Repression of anti-apoptotic genes via AP-1 as a mechanism of apoptosis induction in ventricular cardiomyocytes","volume":"454","author":"A Schlieper","year":"2007","journal-title":"Pfl\u00fcgers Archiv-European Journal of Physiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"11267","DOI":"10.1038\/ncomms11267","article-title":"The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling","volume":"7","author":"Yan-Xiao Ji","year":"2016","journal-title":"Nat Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2174\/13892029113149990002","article-title":"KRAB-zinc finger proteins: a repressor family displaying multiple biological functions","volume":"14","author":"A Lupo","year":"2013","journal-title":"Current genomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbrc.2004.05.182","article-title":"A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE","volume":"320","author":"Z Yi","year":"2004","journal-title":"Biochemical and biophysical research communications"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0006-291X(02)02700-6","article-title":"Expression of a novel Kr\u00fcpple-like zinc-finger gene, ZNF382, in human heart","volume":"299","author":"K Luo","year":"2002","journal-title":"Biochemical and biophysical research communications"},{"key":"ref24","first-page":"615","article-title":"ZNF307(Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy","volume":"4","author":"Cj Yu","year":"2017","journal-title":"Hypertension"},{"key":"ref25","first-page":"1","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"D Fan","year":"2012","journal-title":"Fibrogenesis & tissue repair"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jjcc.2013.06.008","article-title":"Puerarin attenuates pressure overload-induced cardiac hypertrophy","volume":"63","author":"Y Yuan","year":"2014","journal-title":"Journal of cardiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.yjmcc.2012.07.014","article-title":"Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis","volume":"53","author":"BA Mohamed","year":"2012","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncomms2090","article-title":"The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy","volume":"3","author":"A Ucar","year":"2012","journal-title":"Nature communications"},{"key":"ref29","article-title":"Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras and CaMKII Signaling","author":"M Bisserier","year":"2014","journal-title":"Circulation: CIRCULATIONAHA"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.RES.82.7.773","article-title":"Hypertrophy, pathology, and molecular markers of cardiac pathogenesis","volume":"82","author":"KL Vikstrom","year":"1998","journal-title":"Circulation research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.cellsig.2013.02.019","article-title":"Activation of SRE and AP1 by olfactory receptors via the MAPK and Rho dependent pathways","volume":"25","author":"N Benbernou","year":"2013","journal-title":"Cellular signalling"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"L Chang","year":"2001","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.yjmcc.2003.10.001","article-title":"Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models","volume":"35","author":"Q Liang","year":"2003","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"J Heineke","year":"2006","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/01.RES.78.6.954","article-title":"Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes","volume":"78","author":"PE Glennon","year":"1996","journal-title":"Circulation research"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1074\/jbc.273.10.5423","article-title":"Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells","volume":"273","author":"Y Wang","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"H2369","DOI":"10.1152\/ajpheart.00741.2003","article-title":"Transcription activator protein 1 mediates \u03b1-but not \u03b2-adrenergic hypertrophic growth responses in adult cardiomyocytes","volume":"286","author":"G Taimor","year":"2004","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.CIR.0000112596.06954.00","article-title":"Endothelin-1\u2013Induced Cardiac Hypertrophy Is Inhibited by Activation of Peroxisome Proliferator\u2013Activated Receptor-\u03b1 Partly Via Blockade of c-Jun NH2-Terminal Kinase Pathway","volume":"109","author":"Y Irukayama-Tomobe","year":"2004","journal-title":"Circulation"},{"key":"ref39","first-page":"cvt094","article-title":"Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction","author":"C Hill","year":"2013","journal-title":"Cardiovascular research"},{"key":"ref40","first-page":"208","article-title":"Distinct functions of junD in cardiac hypertrophy and heart failure","author":"U Eriksson","year":"2005","journal-title":"Genes & development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/hy0102.100783","article-title":"Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine","volume":"39","author":"T Omura","year":"2002","journal-title":"Hypertension"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e73294","DOI":"10.1371\/journal.pone.0073294","article-title":"The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart","volume":"8","author":"R Windak","year":"2013","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T11:44:45Z","timestamp":1540208685000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186635"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186635","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]}}}