{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:30:48Z","timestamp":1788795048365,"version":"build-2803163510"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186777","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T13:35:42Z","timestamp":1510752942000},"page":"e0186777","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Adherence to inhaled therapies of COPD patients from seven Latin American countries: The LASSYC study"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-7574","authenticated-orcid":true,"given":"Maria","family":"Montes de Oca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando C.","family":"Wehrmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victorina","family":"Lopez Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ugalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Ramirez-Venegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Surmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Miravitlles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.arbr.2017.02.001","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report","volume":"53","author":"CF Vogelmeier","year":"2017","journal-title":"Arch Bronconeumol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/15412555.2011.650241","article-title":"Adherence to long-acting inhaled therapies among patients with chronic obstructive pulmonary disease (COPD)","volume":"9","author":"LM Cecere","year":"2012","journal-title":"COPD"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1378\/chest.99.4.837","article-title":"Medication adherence patterns in chronic obstructive pulmonary disease","volume":"99","author":"JJ Dolce","year":"1991","journal-title":"Chest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11606-014-3029-0","article-title":"Low use and adherence to maintenance medication in chronic obstructive pulmonary disease in the general population","volume":"30","author":"TS Ingebrigtsen","year":"2015","journal-title":"J Gen Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1183\/09031936.94.07030504","article-title":"Patient compliance with inhaled medication. Does combining beta agonists with corticosteroids improve compliance?","volume":"7","author":"CM Bosley","year":"1994","journal-title":"Eur Respir J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/pds.1321","article-title":"Refill adherence for patients with asthma and COPD: comparison of a pharmacy record database with manually collected repeat prescriptions","volume":"16","author":"K Krigsman","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.amjopharm.2010.10.002","article-title":"Impact of maintenance therapy on hospitalization and expenditures for Medicare beneficiaries with chronic obstructive pulmonary disease","volume":"8","author":"BC Stuart","year":"2010","journal-title":"Am J Geriat Pharmacother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjopharm.2012.04.002","article-title":"Association of chronic obstructive pulmonary disease maintenance medication adherence with all-cause hospitalization and spending in a Medicare population","volume":"10","author":"L Simoni-Wastila","year":"2012","journal-title":"Am J Geriatr Pharmacother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.rmed.2010.09.006","article-title":"Treatment of COPD: relationships between daily dosing frequency, adherence, resource use, and costs","volume":"105","author":"EL Toy","year":"2011","journal-title":"Respir Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/thx.2009.113662","article-title":"Adherence to inhaled therapy, mortality and hospital admission in COPD","volume":"64","author":"J Vestbo","year":"2009","journal-title":"Thorax"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/jamp.2009.0785","article-title":"Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped scoring method","volume":"23","author":"GN Rootmensen","year":"2010","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/COPD.S117196","article-title":"The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes","volume":"12","author":"S Bosnic-Anticevich","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1751-7176.2008.07572.x","article-title":"Predictive validity of a medication adherence measure in an outpatient setting","volume":"10","author":"DE Morisky","year":"2008","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref14","first-page":"2","article-title":"Validation of the \u2018Test of the Adherence to Inhalers\u2019(TAI) for Asthma and COPD Patients","volume":"28","author":"V Plaza","year":"2015","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12931-014-0124-z","article-title":"Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials","volume":"15","author":"NK Leidy","year":"2014","journal-title":"Respir Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1477-7525-11-104","article-title":"The development of a patient-reported outcome measure for assessing nighttime symptoms of chronic obstructive pulmonary disease","volume":"11","author":"A Hareendran","year":"2013","journal-title":"Health Qual Life Outcomes"},{"key":"ref17","first-page":"475","article-title":"Evaluation of the psychometric properties of the Nighttime Symptoms of COPD Instrument","volume":"10","author":"M Mocarski","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2147\/COPD.S76157","article-title":"Impact and factors associated with nighttime and early morning symptoms among patients with chronic obstructive pulmonary disease","volume":"10","author":"JJ Stephenson","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S1579-2129(07)60123-2","article-title":"Spirometry reference values after inhalation of 200 microg of salbutamol","volume":"43","author":"R P\u00e9rez-Padilla","year":"2007","journal-title":"Arch Bronconeumol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"ML McHugh","year":"2012","journal-title":"Biochemia Medica"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1378\/chest.128.5.3198","article-title":"Factors associated with medication nonadherence in patients with COPD","volume":"128","author":"J George","year":"2005","journal-title":"Chest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000324453","article-title":"Factors associated with medication adherence in patients with chronic obstructive pulmonary disease","volume":"82","author":"T \u00c1gh","year":"2011","journal-title":"Respiration"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1164\/rccm.201604-0733OC","article-title":"Objective Assessment of Adherence to Inhalers by Patients with Chronic Obstructive Pulmonary Disease","volume":"195","author":"I Sulaiman","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3109\/15412555.2015.1118449","article-title":"Differences in adherence and non-adherence behaviour patterns to inhaler devices between COPD and asthma patients","volume":"13","author":"V Plaza","year":"2016","journal-title":"COPD"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T10:47:17Z","timestamp":1540032437000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186777"}},"subtitle":[],"editor":[{"given":"Sanjay Haresh","family":"Chotirmall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186777","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}