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Preventing overdose deaths in Europe [Internet]. Lisbon, Portugal; 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.salledeconsommation.fr\/_media\/emcdda-2013-preventing-overdose-deaths.pdf\" xlink:type=\"simple\">http:\/\/www.salledeconsommation.fr\/_media\/emcdda-2013-preventing-overdose-deaths.pdf<\/ext-link>"},{"article-title":"Preventing opioid overdoses in Europe: A critical assessment of known risk factors and preventative measures","year":"2012","author":"M Frisher","key":"ref39"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.drugalcdep.2013.02.007","article-title":"Development of Opioid Overdose Knowledge (OOKS) and Attitudes (OOAS) Scales for take-home naloxone training evaluation","volume":"132","author":"AV Williams","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1360-0443.2010.02990.x","article-title":"Meta-analysis of drug-related deaths soon after release from prison","volume":"105","author":"ELC Merrall","year":"2010","journal-title":"Addiction"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/add.13200","article-title":"Clinical risk factors for death after release from prison in Washington State: a nested case-control study","volume":"111","author":"IA Binswanger","year":"2016","journal-title":"Addiction"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T13:31:41Z","timestamp":1540215101000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186833"}},"subtitle":[],"editor":[{"given":"Georgios \u039a","family":"Nikolopoulos","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186833","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}