{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:22:08Z","timestamp":1792844528746,"version":"4.5.0"},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Labex ICST"},{"name":"Erasmus Mundus Averroes"},{"name":"L\u2019Or\u00e9al-UNESCO for Women in Science"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186864","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T18:03:00Z","timestamp":1509040980000},"page":"e0186864","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts"],"prefix":"10.1371","volume":"12","author":[{"given":"Chaymae","family":"El Alaoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Chemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufiq","family":"Fechtali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-7604","authenticated-orcid":true,"given":"Philippe","family":"Lory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.95849","article-title":"Historical review of medicinal plants&apos; usage","volume":"6","author":"BB Petrovska","year":"2012","journal-title":"Pharmacogn Rev"},{"key":"ref2","first-page":"59","article-title":"Medicinal plants, human health and biodiversity: a broad review","volume":"147","author":"T Sen","year":"2015","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"Pt B","key":"ref3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yebeh.2015.05.012","article-title":"A pharmacological basis of herbal medicines for epilepsy","volume":"52","author":"NJ Sucher","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrd1657","article-title":"The evolving role of natural products in drug discovery","volume":"4","author":"FE Koehn","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0030-1250136","article-title":"Biosynthesis and therapeutic properties of Lavandula essential oil constituents","volume":"77","author":"G Woronuk","year":"2011","journal-title":"Planta Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"681304","DOI":"10.1155\/2013\/681304","article-title":"Lavender and the nervous system","volume":"2013","author":"PH Koulivand","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/10408398.2010.490883","article-title":"Rosemary and cancer prevention: preclinical perspectives","volume":"51","author":"SN Ngo","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ptr.1103","article-title":"Biological activities of lavender essential oil","volume":"16","author":"HM Cavanagh","year":"2002","journal-title":"Phytother Res"},{"issue":"1\u20132","key":"ref9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-8741(99)00198-1","article-title":"Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L","volume":"71","author":"AH Gilani","year":"2000","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"e59998","DOI":"10.1371\/journal.pone.0059998","article-title":"Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels","volume":"8","author":"AM Schuwald","year":"2013","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.physbeh.2005.06.031","article-title":"Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office","volume":"86","author":"J Lehrner","year":"2005","journal-title":"Physiol Behav"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/j.chroma.2009.11.032","article-title":"Green processes for the extraction of bioactives from Rosemary: Chemical and functional characterization via ultra-performance liquid chromatography-tandem mass spectrometry and in-vitro assays","volume":"1217","author":"M Herrero","year":"2010","journal-title":"J Chromatogr A"},{"issue":"21","key":"ref13","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1021\/jf8016833","article-title":"Revealing the metabonomic variation of rosemary extracts using 1H NMR spectroscopy and multivariate data analysis","volume":"56","author":"C Xiao","year":"2008","journal-title":"J Agric Food Chem"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jep.2006.12.011","article-title":"Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents","volume":"111","author":"ME Gonzalez-Trujano","year":"2007","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/jmf.2007.0524","article-title":"Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models","volume":"11","author":"I Takaki","year":"2008","journal-title":"J Med Food"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10571-010-9502-3","article-title":"Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y","volume":"30","author":"SE Park","year":"2010","journal-title":"Cell Mol Neurobiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fitote.2013.09.012","article-title":"Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain","volume":"91","author":"M Ozarowski","year":"2013","journal-title":"Fitoterapia"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/bcpt.12335","article-title":"Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation","volume":"116","author":"J Rocha","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"451682","DOI":"10.5402\/2011\/451682","article-title":"Effect of rosmarinic and caffeic acids on inflammatory and nociception process in rats","volume":"2011","author":"GD Gamaro","year":"2011","journal-title":"ISRN Pharmacol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s11064-013-1088-y","article-title":"Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes","volume":"38","author":"X Jin","year":"2013","journal-title":"Neurochem Res"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1211\/jpp.60.11.0013","article-title":"Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels","volume":"60","author":"L Huang","year":"2008","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jep.2013.03.028","article-title":"Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA\/benzodiazepine neurotransmission","volume":"147","author":"LR Chioca","year":"2013","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated T-type calcium channels","volume":"83","author":"E Perez-Reyes","year":"2003","journal-title":"Physiol Rev"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1152\/jn.00166.2006","article-title":"Bursting of thalamic neurons and states of vigilance","volume":"95","author":"RR Llinas","year":"2006","journal-title":"J Neurophysiol"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"WA Catterall","year":"2005","journal-title":"Pharmacol Rev"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1523\/JNEUROSCI.19-06-01895.1999","article-title":"Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels","volume":"19","author":"EM Talley","year":"1999","journal-title":"J Neurosci"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1073\/pnas.0409644102","article-title":"Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep","volume":"102","author":"MP Anderson","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"ref28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(00)01832-9","article-title":"Overexpression of T-type calcium channels in HEK-293 cells increases intracellular calcium without affecting cellular proliferation","volume":"478","author":"J Chemin","year":"2000","journal-title":"FEBS letters"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1523\/JNEUROSCI.22-16-06856.2002","article-title":"Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line","volume":"22","author":"J Chemin","year":"2002","journal-title":"J Neurosci"},{"issue":"Pt 1","key":"ref30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2001.013269","article-title":"Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability","volume":"540","author":"J Chemin","year":"2002","journal-title":"J Physiol"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.bbamem.2012.07.028","article-title":"T-type calcium channels in burst-firing, network synchrony, and epilepsy","volume":"1828","author":"SM Cain","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception","volume":"24","author":"E Bourinet","year":"2005","journal-title":"The EMBO journal"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1476-5381.2011.01256.x","article-title":"T-type voltage-gated calcium channels as targets for the development of novel pain therapies","volume":"163","author":"SM Todorovic","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"24","key":"ref34","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1093\/emboj\/20.24.7033","article-title":"Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide","volume":"20","author":"J Chemin","year":"2001","journal-title":"The EMBO journal"},{"issue":"42","key":"ref35","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1523\/JNEUROSCI.2919-09.2009","article-title":"T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids","volume":"29","author":"G Barbara","year":"2009","journal-title":"J Neurosci"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/mol.113.089581","article-title":"Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2","volume":"85","author":"M Cazade","year":"2014","journal-title":"Mol Pharmacol"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/3669","article-title":"Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin","volume":"1","author":"RS Chuang","year":"1998","journal-title":"Nat Neurosci"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.113.207936","article-title":"Effects of eugenol on T-type Ca2+ channel isoforms","volume":"347","author":"H Seo","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"issue":"23","key":"ref39","doi-asserted-by":"crossref","first-page":"16124","DOI":"10.1074\/jbc.M707104200","article-title":"Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol","volume":"283","author":"HR Ross","year":"2008","journal-title":"J Biol Chem"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/np900227x","article-title":"Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current","volume":"72","author":"JA Enyeart","year":"2009","journal-title":"J Nat Prod"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1124\/mol.105.020842","article-title":"T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine","volume":"69","author":"A Traboulsie","year":"2006","journal-title":"Mol Pharmacol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)38902-5","article-title":"Mibefradil block of cloned T-type calcium channels","volume":"295","author":"RL Martin","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential","volume":"67","author":"GW Zamponi","year":"2015","journal-title":"Pharmacol Rev"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00702-004-0187-y","article-title":"Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells","volume":"112","author":"K Narusuye","year":"2005","journal-title":"J Neural Transm (Vienna)"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0944-7113(99)80044-0","article-title":"Anticonvulsant properties of linalool in glutamate-related seizure models","volume":"6","author":"E Elisabetsky","year":"1999","journal-title":"Phytomedicine"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/phrs.2000.0671","article-title":"Linalool modifies the nicotinic receptor-ion channel kinetics at the mouse neuromuscular junction","volume":"42","author":"L Re","year":"2000","journal-title":"Pharmacol Res"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.phymed.2008.08.001","article-title":"Inhaled linalool-induced sedation in mice","volume":"16","author":"VM Linck","year":"2009","journal-title":"Phytomedicine"},{"issue":"8\u20139","key":"ref48","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.phymed.2009.10.002","article-title":"Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice","volume":"17","author":"VM Linck","year":"2010","journal-title":"Phytomedicine"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1085\/jgp.108.6.525","article-title":"T-type Ca2+ channel lowers the threshold of spike generation in the newt olfactory receptor cell","volume":"108","author":"F Kawai","year":"1996","journal-title":"J Gen Physiol"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1476-5381.2009.00213.x","article-title":"Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death","volume":"157","author":"S Fallarini","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1021\/np50051a009","article-title":"Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes","volume":"50","author":"Y Kimura","year":"1987","journal-title":"J Nat Prod"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0944-7113(00)80015-X","article-title":"Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn","volume":"7","author":"MA Kelm","year":"2000","journal-title":"Phytomedicine"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0006-2952(99)00044-1","article-title":"Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b","volume":"57","author":"A Sahu","year":"1999","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/eji.200323010","article-title":"Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner","volume":"33","author":"J Won","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.ph.58.030196.001553","article-title":"Low-threshold calcium currents in central nervous system neurons","volume":"58","author":"JR Huguenard","year":"1996","journal-title":"Annu Rev Physiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.pa.24.040184.002131","article-title":"Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs","volume":"24","author":"LM Hondeghem","year":"1984","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"24","key":"ref57","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1073\/pnas.94.24.13323","article-title":"Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation","volume":"94","author":"S Hering","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"ref58","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1113\/JP271053","article-title":"Hypoxic induction of T-type Ca(2+) channels in rat cardiac myocytes: role of HIF-1alpha and RhoA\/ROCK signalling","volume":"593","author":"P Gonzalez-Rodriguez","year":"2015","journal-title":"J Physiol"},{"issue":"Pt 1","key":"ref59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1113\/jphysiol.2007.132274","article-title":"Chronic hypoxia up-regulates alpha1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells","volume":"584","author":"V Carabelli","year":"2007","journal-title":"J Physiol"},{"issue":"13","key":"ref60","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1074\/jbc.M108754200","article-title":"Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells","volume":"277","author":"P Mariot","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/bcp.12205","article-title":"Low threshold T-type calcium channels as targets for novel epilepsy treatments","volume":"77","author":"KL Powell","year":"2014","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1523\/JNEUROSCI.15-04-03110.1995","article-title":"Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy","volume":"15","author":"E Tsakiridou","year":"1995","journal-title":"J Neurosci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuropharm.2015.09.032","article-title":"Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model","volume":"101","author":"S Sakkaki","year":"2016","journal-title":"Neuropharmacology"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/14728222.11.5.717","article-title":"Towards the discovery of novel T-type calcium channel blockers","volume":"11","author":"P Lory","year":"2007","journal-title":"Expert Opin Ther Targets"},{"issue":"5","key":"ref65","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1124\/mol.60.5.1121","article-title":"Block of cloned human T-type calcium channels by succinimide antiepileptic drugs","volume":"60","author":"JC Gomora","year":"2001","journal-title":"Mol Pharmacol"},{"issue":"121","key":"ref66","doi-asserted-by":"crossref","first-page":"121ra19","DOI":"10.1126\/scitranslmed.3003120","article-title":"T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures","volume":"4","author":"E Tringham","year":"2012","journal-title":"Sci Transl Med"},{"issue":"26","key":"ref67","doi-asserted-by":"crossref","first-page":"15222","DOI":"10.1073\/pnas.96.26.15222","article-title":"Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography","volume":"96","author":"RR Llinas","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1744-8069-10-77","article-title":"NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors","volume":"10","author":"ND Berger","year":"2014","journal-title":"Mol Pain"},{"issue":"6","key":"ref69","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve","volume":"99","author":"MM Jagodic","year":"2008","journal-title":"J Neurophysiol"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.103.060814","article-title":"NNC 55\u20130396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2, 3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels","volume":"309","author":"L Huang","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"ref71","first-page":"7","article-title":"Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex","volume":"11","author":"FY Shen","year":"2015","journal-title":"Mol Pain"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bcp.2014.03.015","article-title":"A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats","volume":"89","author":"MF Jarvis","year":"2014","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"ref73","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/j.pain.0000000000000263","article-title":"A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain","volume":"156","author":"D Ziegler","year":"2015","journal-title":"Pain"},{"issue":"11","key":"ref74","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1097\/j.pain.0000000000000249","article-title":"Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial","volume":"156","author":"J Serra","year":"2015","journal-title":"Pain"},{"issue":"Suppl 2","key":"ref75","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1111\/jns.12080_2","article-title":"Z944: a first in class T-type calcium channel modulator for the treatment of pain","volume":"19","author":"M Lee","year":"2014","journal-title":"J Peripher Nerv Syst"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.eplepsyres.2015.01.001","article-title":"Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)","volume":"111","author":"M Bialer","year":"2015","journal-title":"Epilepsy Res"},{"issue":"3","key":"ref77","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/bph.12321","article-title":"Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism","volume":"170","author":"TD Hill","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/bja\/aen119","article-title":"Therapeutic potential of cannabis in pain medicine","volume":"101","author":"RD Hosking","year":"2008","journal-title":"Br J Anaesth"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:16:34Z","timestamp":1750965394000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186864"}},"subtitle":[],"editor":[{"given":"J. David","family":"Spafford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":78,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186864","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}