{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:42:18Z","timestamp":1768617738523,"version":"3.49.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK072482"],"award-info":[{"award-number":["DK072482"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL135816"],"award-info":[{"award-number":["R35HL135816"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2R01HL105487"],"award-info":[{"award-number":["2R01HL105487"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["YFA130008"],"award-info":[{"award-number":["YFA130008"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["RG-305752"],"award-info":[{"award-number":["RG-305752"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0186984","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T17:31:43Z","timestamp":1509125503000},"page":"e0186984","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of ferrets for electrophysiologic monitoring of ion transport"],"prefix":"10.1371","volume":"12","author":[{"given":"Niroop","family":"Kaza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Vamsee","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M.","family":"Cadillac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Trombley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Dohm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin S.","family":"Harrod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-0133","authenticated-orcid":true,"given":"Steven M.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/cea.12712","article-title":"Chronic inflammatory airway diseases: the central role of the epithelium revisited","volume":"46","author":"ST Gohy","year":"2016","journal-title":"Clin Exp Allergy"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/archinte.160.11.1683","article-title":"Obstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988\u20131994","volume":"160","author":"DM Mannino","year":"2000","journal-title":"Arch Intern Med"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13353-013-0182-9","article-title":"Genetically modified pigs to model human diseases","volume":"55","author":"T Flisikowska","year":"2014","journal-title":"J Appl Genet"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MCP.0b013e32834b14c9","article-title":"New animal models of cystic fibrosis: what are they teaching us?","volume":"17","author":"NW Keiser","year":"2011","journal-title":"Curr Opin Pulm Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-61779-120-8_19","article-title":"Comparative biology of cystic fibrosis animal models","volume":"742","author":"JT Fisher","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejphar.2015.03.029","article-title":"Preclinical murine models of Chronic Obstructive Pulmonary Disease","volume":"759","author":"R Vlahos","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1517\/17460441.2014.909805","article-title":"Animal models of chronic obstructive pulmonary disease","volume":"9","author":"M Fricker","year":"2014","journal-title":"Expert Opin Drug Discov"},{"issue":"1 Pt 1","key":"ref8","doi-asserted-by":"crossref","first-page":"C293","DOI":"10.1152\/ajpcell.1994.267.1.C293","article-title":"Anomalies in ion transport in CF mouse tracheal epithelium","volume":"267","author":"BR Grubb","year":"1994","journal-title":"Am J Physiol"},{"issue":"1 Suppl","key":"ref9","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1152\/physrev.1999.79.1.S193","article-title":"Pathophysiology of gene-targeted mouse models for cystic fibrosis","volume":"79","author":"BR Grubb","year":"1999","journal-title":"Physiol Rev"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI43052","article-title":"Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis","volume":"120","author":"X Sun","year":"2010","journal-title":"J Clin Invest"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1165\/rcmb.2013-0261OC","article-title":"Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets","volume":"50","author":"X Sun","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"e46605","DOI":"10.1371\/journal.pone.0046605","article-title":"Neurovirulence of H5N1 infection in ferrets is mediated by multifocal replication in distinct permissive neuronal cell regions","volume":"7","author":"JR Plourde","year":"2012","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coviro.2015.06.002","article-title":"Animal models for influenza virus transmission studies: a historical perspective","volume":"13","author":"NM Bouvier","year":"2015","journal-title":"Curr Opin Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2147\/IDR.S58551","article-title":"Modeling human influenza infection in the laboratory","volume":"8","author":"KA Radigan","year":"2015","journal-title":"Infect Drug Resist"},{"issue":"15","key":"ref15","first-page":"e87536","article-title":"A ferret model of COPD-related chronic bronchitis","volume":"1","author":"SV Raju","year":"2016","journal-title":"JCI Insight"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1172\/JCI83922","article-title":"Acidic pH increases airway surface liquid viscosity in cystic fibrosis","volume":"126","author":"XX Tang","year":"2016","journal-title":"J Clin Invest"},{"issue":"6272","key":"ref17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aad5589","article-title":"Airway acidification initiates host defense abnormalities in cystic fibrosis mice","volume":"351","author":"VS Shah","year":"2016","journal-title":"Science"},{"issue":"6198","key":"ref18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1255825","article-title":"Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis","volume":"345","author":"MJ Hoegger","year":"2014","journal-title":"Science"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1378\/chest.10-0179","article-title":"An international randomized multicenter comparison of nasal potential difference techniques","volume":"138","author":"GM Solomon","year":"2010","journal-title":"Chest"},{"issue":"44","key":"ref20","doi-asserted-by":"crossref","first-page":"18825","DOI":"10.1073\/pnas.0904709106","article-title":"Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770","volume":"106","author":"F Van Goor","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"L587","DOI":"10.1152\/ajplung.00465.2010","article-title":"Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators","volume":"301","author":"LC Pyle","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-61779-117-8_6","article-title":"Nasal potential difference measurements to assess CFTR ion channel activity","volume":"741","author":"SM Rowe","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"e57317","DOI":"10.1371\/journal.pone.0057317","article-title":"Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice","volume":"8","author":"EL Saussereau","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1378\/chest.13-0274","article-title":"Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD","volume":"144","author":"MT Dransfield","year":"2013","journal-title":"Chest"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.3310\/eme03050","article-title":"A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis","author":"E Alton","year":"2016"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1378\/chest.12-2431","article-title":"Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis","volume":"144","author":"SM Rowe","year":"2013","journal-title":"Chest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-62703-125-7_8","article-title":"Human nasal and tracheo-bronchial respiratory epithelial cell culture","volume":"945","author":"ML Fulcher","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"e66955","DOI":"10.1371\/journal.pone.0066955","article-title":"Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation","volume":"8","author":"SM Rowe","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1164\/rccm.200408-1116OC","article-title":"Potential difference measurements in the lower airway of children with and without cystic fibrosis","volume":"171","author":"JC Davies","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.stem.2016.05.012","article-title":"Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells","volume":"19","author":"H Mou","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"49","key":"ref31","doi-asserted-by":"crossref","first-page":"20035","DOI":"10.1073\/pnas.1213241109","article-title":"Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells","volume":"109","author":"FA Suprynowicz","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-61779-117-8_4","article-title":"Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators","volume":"741","author":"T Neuberger","year":"2011","journal-title":"Methods in molecular biology"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"e91253","DOI":"10.1371\/journal.pone.0091253","article-title":"Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats","volume":"9","author":"KL Tuggle","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1203\/00006450-199608000-00008","article-title":"Phenotypic abnormalities in long-term surviving cystic fibrosis mice","volume":"40","author":"G Kent","year":"1996","journal-title":"Pediatr Res"},{"issue":"Suppl 4","key":"ref35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/089583700750019549","article-title":"Animal models of chronic bronchitis and their relevance to studies of particle-induced disease","volume":"12","author":"KJ Nikula","year":"2000","journal-title":"Inhalation toxicology"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1165\/rcmb.2012-0433OC","article-title":"Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets","volume":"49","author":"JT Fisher","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/jappl.1986.61.3.1065","article-title":"Ion transport across cat and ferret tracheal epithelia","volume":"61","author":"RJ Corrales","year":"1986","journal-title":"J Appl Physiol (1985)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0186984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T18:50:55Z","timestamp":1659725455000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0186984"}},"subtitle":[],"editor":[{"given":"Diego","family":"Alvarez de la Rosa","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0186984","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}