{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:12:35Z","timestamp":1781043155206,"version":"3.54.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","award":["01C-102"],"award-info":[{"award-number":["01C-102"]}],"id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0187068","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T14:17:43Z","timestamp":1509027463000},"page":"e0187068","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children"],"prefix":"10.1371","volume":"12","author":[{"given":"Genoveva","family":"Keustermans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-8128","authenticated-orcid":true,"given":"Laila B.","family":"van der Heijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berlinda","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Scholman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos","family":"Nuboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pasterkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berent","family":"Prakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilco","family":"de Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kalkhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arieke J.","family":"Janse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk S.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1056\/NEJMoa1503840","article-title":"Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood","volume":"374","author":"G Twig","year":"2016","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1056\/NEJMoa072515","article-title":"Childhood body-mass index and the risk of coronary heart disease in adulthood","volume":"357","author":"JL Baker","year":"2007","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ijo.2011.186","article-title":"Childhood obesity and risk of the adult metabolic syndrome: a systematic review","volume":"36","author":"LJ Lloyd","year":"2012","journal-title":"Int J Obes (Lond)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"N Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fphys.2015.00304","article-title":"Adipokines, diabetes and atherosclerosis: an inflammatory association","volume":"6","author":"LC Freitas Lima","year":"2015","journal-title":"Front Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s00125-012-2641-y","article-title":"Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14(++) monocytes","volume":"55","author":"HS Schipper","year":"2012","journal-title":"Diabetologia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vph.2015.10.007","article-title":"Chemerin in renal dysfunction and cardiovascular disease","volume":"77","author":"M Bonomini","year":"2016","journal-title":"Vascul Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/obr.12009","article-title":"Towards an integrative approach to understanding the role of chemerin in human health and disease","volume":"14","author":"JL Rourke","year":"2013","journal-title":"Obes Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrrheum.2016.209","article-title":"Leptin in the interplay of inflammation, metabolism and immune system disorders","volume":"13","author":"V Abella","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cmet.2013.01.001","article-title":"Adiponectin receptor as a key player in healthy longevity and obesity-related diseases","volume":"17","author":"T Yamauchi","year":"2013","journal-title":"Cell Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tem.2014.03.009","article-title":"Role of anti-inflammatory adipokines in obesity-related diseases","volume":"25","author":"K Ohashi","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.beem.2013.09.003","article-title":"Adiponectin receptors: a review of their structure, function and how they work","volume":"28","author":"T Yamauchi","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0006-291X(02)02462-2","article-title":"Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation","volume":"298","author":"Z Tian","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1210\/en.2007-1516","article-title":"Resistance of Janus kinase-2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesity","volume":"149","author":"H Nave","year":"2008","journal-title":"Endocrinology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fimmu.2013.00332","article-title":"Role of adipokines signaling in the modulation of T cells function","volume":"4","author":"C Procaccini","year":"2013","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2249.2003.02190.x","article-title":"Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action","volume":"133","author":"V Sanchez-Margalet","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1196\/annals.1447.021","article-title":"The distribution of adiponectin receptors on human peripheral blood mononuclear cells","volume":"1150","author":"TT Pang","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1053\/meta.2000.18519","article-title":"Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: implications for leptin's actions","volume":"49","author":"PC Tsiotra","year":"2000","journal-title":"Metabolism"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e27608","DOI":"10.1371\/journal.pone.0027608","article-title":"Increase in prevalence of overweight in Dutch children and adolescents: a comparison of nationwide growth studies in 1980, 1997 and 2009","volume":"6","author":"Y Schonbeck","year":"2011","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"TJ Cole","year":"2000","journal-title":"BMJ"},{"key":"ref21","article-title":"Development of a Dutch intervention for obese young children","author":"E van Hoek","year":"2016","journal-title":"Health Promot Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"A Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1373\/clinchem.2010.146118","article-title":"A multiplex immunoassay for human adipokine profiling","volume":"56","author":"HS Schipper","year":"2010","journal-title":"Clin Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nri3229","article-title":"Standardizing immunophenotyping for the Human Immunology Project","volume":"12","author":"HT Maecker","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.atherosclerosis.2011.12.014","article-title":"Adiponectin-AdipoR1\/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses","volume":"221","author":"L Tian","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1096\/fj.14-253831","article-title":"Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response","volume":"29","author":"CM van Stijn","year":"2015","journal-title":"FASEB J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/CIRCGENETICS.111.960385","article-title":"Elevated CD14++CD16- monocytes predict cardiovascular events","volume":"5","author":"KE Berg","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1160\/TH16-02-0091","article-title":"Role and analysis of monocyte subsets in cardiovascular disease. Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis"","volume":"116","author":"C Weber","year":"2016","journal-title":"Thromb Haemost"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/imm.12262","article-title":"Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential","volume":"142","author":"D Cipolletta","year":"2014","journal-title":"Immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","article-title":"PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells","volume":"486","author":"D Cipolletta","year":"2012","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4049\/jimmunol.1301158","article-title":"Leptin metabolically licenses T cells for activation to link nutrition and immunity","volume":"192","author":"DC Saucillo","year":"2014","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.4049\/jimmunol.1402996","article-title":"Leptin receptor signaling in T cells is required for Th17 differentiation","volume":"194","author":"BS Reis","year":"2015","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molmed.2015.12.001","article-title":"Leptin Regulation of Immune Responses","volume":"22","author":"C Naylor","year":"2016","journal-title":"Trends Mol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/oby.21383","article-title":"Obesity decreases B cell responses in young and elderly individuals","volume":"24","author":"D Frasca","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"ref36","article-title":"B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection","author":"R Kosaraju","year":"2017","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1016\/j.vaccine.2016.08.027","article-title":"Hepatitis B vaccine response in obesity: A meta-analysis","volume":"34","author":"W Fan","year":"2016","journal-title":"Vaccine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1463-1326.2006.00614.x","article-title":"Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients","volume":"9","author":"L Alberti","year":"2007","journal-title":"Diabetes Obes Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-2840-10-14","article-title":"Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease","volume":"10","author":"A Kollias","year":"2011","journal-title":"Cardiovasc Diabetol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0187068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T02:18:10Z","timestamp":1570241890000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0187068"}},"subtitle":[],"editor":[{"given":"Silke","family":"Appel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0187068","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}