{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:59:54Z","timestamp":1783490394264,"version":"3.55.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Arizona Biomedical Research Commission Research","award":["ADHS14-082988"],"award-info":[{"award-number":["ADHS14-082988"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0187188","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T17:03:01Z","timestamp":1510074181000},"page":"e0187188","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Expression patterns of conjunctival mucin 5AC and aquaporin 5 in response to acute dry eye stress"],"prefix":"10.1371","volume":"12","author":[{"given":"Dhruva","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0259-3607","authenticated-orcid":true,"given":"Mingwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(03)00204-5","article-title":"Distribution of mucins at the ocular surface","volume":"78","author":"IK Gipson","year":"2004","journal-title":"Exp Eye Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.exer.2010.02.014","article-title":"Membrane-tethered mucins have multiple functions on the ocular surface","volume":"90","author":"B Govindarajan","year":"2010","journal-title":"Exp Eye Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","article-title":"Role of mucins in the function of the corneal and conjunctival epithelia","volume":"231","author":"IK Gipson","year":"2003","journal-title":"Int Rev of Cytolog"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1167\/iovs.13-13194","article-title":"The ocular surface phenotype of Muc5ac and Muc5b null mice","volume":"55","author":"CK Marko","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","first-page":"1004","article-title":"Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome","volume":"43","author":"P Argueso","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"TD Blalock","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0161-6420(97)30330-3","article-title":"Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation","volume":"104","author":"SC Pflugfelder","year":"1997","journal-title":"Ophthalmology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0161-6420(00)00347-X","article-title":"Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca","volume":"107","author":"PJ Pisella","year":"2000","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00003226-200111000-00019","article-title":"Quantification of MUC5AC protein in human tears","volume":"20","author":"H Zhao","year":"2001","journal-title":"Cornea"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1542-0124(12)70086-1","article-title":"Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","year":"2007","journal-title":"The ocular surface"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00232-005-0849-1","article-title":"Aquaporins and CFTR in ocular epithelial fluid transport","volume":"210","author":"MH Levin","year":"2006","journal-title":"J Membr Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0014-5793(03)01083-4","article-title":"Aquaporin water channels: molecular mechanisms for human diseases","volume":"555","author":"P Agre","year":"2003","journal-title":"FEBS Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1167\/iovs.15-17550","article-title":"Tear Production After Bilateral Main Lacrimal Gland Resection in Rabbits","volume":"56","author":"D Bhattacharya","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1167\/iovs.04-0816","article-title":"Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva","volume":"45","author":"MH Levin","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.exer.2006.04.006","article-title":"Identification and localization of aquaporin 5 in the mammalian conjunctival epithelium","volume":"83","author":"H Oen","year":"2006","journal-title":"Exp Eye Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2006.01.103","article-title":"Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells","volume":"342","author":"Z Chen","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","first-page":"1645","article-title":"Aquaporin 5 expression increases mucin production in lung adenocarcinoma","volume":"25","author":"ZQ Zhang","year":"2011","journal-title":"Oncol Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/path.2702","article-title":"Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer","volume":"221","author":"Z Zhang","year":"2010","journal-title":"J Pathol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1745-7254.2007.00608.x","article-title":"Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease","volume":"28","author":"K Wang","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/bjophthalmol-2011-301448","article-title":"A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients","volume":"96","author":"E Takamura","year":"2012","journal-title":"The Br J of Ophthalmol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.ophtha.2012.06.052","article-title":"Rebamipide (OPC-12759) in the treatment of dry eye: a randomized, double-masked, multicenter, placebo-controlled phase II study","volume":"119","author":"S Kinoshita","year":"2012","journal-title":"Ophthalmology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10248","DOI":"10.1038\/srep10248","article-title":"JBP485 promotes tear and mucin secretion in ocular surface epithelia","volume":"5","author":"T Nakamura","year":"2015","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3964642","DOI":"10.1155\/2016\/3964642","article-title":"Evaluating the Functionality of Conjunctiva Using a Rabbit Dry Eye Model","volume":"2016","author":"Y Ning","year":"2016","journal-title":"J Ophthalmol"},{"key":"ref24","first-page":"1455","article-title":"Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro","volume":"42","author":"MA Shatos","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"636812","DOI":"10.1155\/2013\/636812","article-title":"Modulation of conjunctival goblet cell function by inflammatory cytokines","volume":"2013","author":"L Contreras-Ruiz","year":"2013","journal-title":"Mediators of inflammation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.exer.2005.08.019","article-title":"JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells","volume":"82","author":"DQ Li","year":"2006","journal-title":"Exp Eye Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e75138","DOI":"10.1371\/journal.pone.0075138","article-title":"Toxoplasma gondii soluble tachyzoite antigen triggers protective mechanisms against fatal intestinal pathology in oral infection of C57BL\/6 mice","volume":"8","author":"L Benevides","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"22070","DOI":"10.1074\/jbc.271.36.22070","article-title":"Adenovirus-mediated expression of aquaporin-5 in epithelial cells","volume":"271","author":"C Delporte","year":"1996","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1006\/bbrc.2001.5287","article-title":"Polarized sorting of aquaporins 5 and 8 in stable MDCK-II transfectants","volume":"285","author":"RB Wellner","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3109\/02713689409047012","article-title":"Conjunctival epithelial cells do not transdifferentiate in organotypic cultures: expression of K12 keratin is restricted to corneal epithelium","volume":"13","author":"WY Chen","year":"1994","journal-title":"Curr Eye Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.exer.2006.10.005","article-title":"Development of immortalized rat conjunctival epithelial cell lines: an in vitro model to examine transepithelial antigen delivery","volume":"84","author":"NL O'Sullivan","year":"2007","journal-title":"Exp Eye Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"MC Rose","year":"2006","journal-title":"Physiolog Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/OPX.0000000000000664","article-title":"Altered Mucin and Glycoprotein Expression in Dry Eye Disease","volume":"92","author":"DN Stephens","year":"2015","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1167\/iovs.10-5782","article-title":"Entrapment of conjunctival goblet cells by desiccation-induced cornification","volume":"52","author":"RM Corrales","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","first-page":"2609","article-title":"Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye","volume":"43","author":"ME Stern","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated Sjogren's Syndrome-like lacrimal keratoconjunctivitis","volume":"176","author":"JY Niederkorn","year":"2006","journal-title":"J Immunol"},{"key":"ref38","first-page":"1720","article-title":"MUC1 expression in Sjogren's syndrome, KCS, and control subjects","volume":"16","author":"B Caffery","year":"2010","journal-title":"Mol Vis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/ICO.0b013e31820d852a","article-title":"Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye","volume":"30","author":"IK Gipson","year":"2011","journal-title":"Cornea"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/j.1398-9995.2008.01781.x","article-title":"Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis","volume":"63","author":"M Dogru","year":"2008","journal-title":"Allergy"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","article-title":"Regulation of mucin and fluid secretion by conjunctival epithelial cells","volume":"21","author":"DA Dartt","year":"2002","journal-title":"Progress in retinal and eye research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/glycob\/cwm027","article-title":"The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity","volume":"17","author":"AN Round","year":"2007","journal-title":"Glycobiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1172\/JCI73469","article-title":"Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure","volume":"124","author":"AG Henderson","year":"2014","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e0138988","DOI":"10.1371\/journal.pone.0138988","article-title":"Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs","volume":"10","author":"M Kesimer","year":"2015","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/292340a0","article-title":"Control of mucus hydration as a Donnan equilibrium process","volume":"292","author":"PY Tam","year":"1981","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"L15","DOI":"10.1152\/ajplung.00194.2009","article-title":"Unpacking a gel-forming mucin: a view of MUC5B organization after granular release","volume":"298","author":"M Kesimer","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/exer.1998.0520","article-title":"Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva","volume":"67","author":"JE Jumblatt","year":"1998","journal-title":"Exp Eye Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/bjophthalmol-2014-306084","article-title":"A randomised, parallel-group comparison study of diquafosol ophthalmic solution in patients with dry eye in China and Singapore","volume":"99","author":"L Gong","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1165\/rcmb.2003-0211OC","article-title":"Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells","volume":"31","author":"PA Kemp","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/01.ico.0000133993.14768.a9","article-title":"Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye","volume":"23","author":"J Tauber","year":"2004","journal-title":"Cornea"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1517\/13543784.13.1.47","article-title":"Diquafosol tetrasodium: a novel dry eye therapy","volume":"13","author":"KK Nichols","year":"2004","journal-title":"Opin Investig Drugs"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000076887","article-title":"Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva","volume":"36","author":"T Murakami","year":"2004","journal-title":"Ophthalmic Res"},{"key":"ref53","article-title":"A randomised, parallel-group comparison study of diquafosol ophthalmic solution in patients with dry eye in China and Singapore","author":"L Gong","year":"2015","journal-title":"Br J of Ophthalmol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ajo.2013.09.009","article-title":"Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes","volume":"157","author":"N Yokoi","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1111\/aos.12443","article-title":"Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous-deficient dry eye","volume":"92","author":"S Koh","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3109\/02713683.2014.967871","article-title":"Diquafosol Tetrasodium Increases the Concentration of Mucin-like Substances in Tears of Healthy Human Subjects","volume":"40","author":"C Shigeyasu","year":"2015","journal-title":"Curr Eye Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tvjl.2014.05.022","article-title":"Conjunctival expression of the P2Y2 receptor and the effects of 3% diquafosol ophthalmic solution in dogs","volume":"202","author":"K Terakado","year":"2014","journal-title":"Vet J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/ICO.0000000000000136","article-title":"Effect of diquafosol tetrasodium eye drop for persistent dry eye after laser in situ keratomileusis","volume":"33","author":"Y Mori","year":"2014","journal-title":"Cornea"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"C Widmann","year":"1999","journal-title":"Physiol Rev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1089\/neu.2012.2430","article-title":"Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes","volume":"29","author":"C Nito","year":"2012","journal-title":"J Neurotrauma"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1074\/jbc.275.12.9070","article-title":"Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway","volume":"275","author":"JD Hoffert","year":"2000","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"44525","DOI":"10.1074\/jbc.M304368200","article-title":"Hyperosmolar mannitol simulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytes","volume":"278","author":"H Arima","year":"2003","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"15765","DOI":"10.1074\/jbc.M209980200","article-title":"Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene","volume":"278","author":"F Umenishi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm1469","article-title":"From structure to disease: the evolving tale of aquaporin biology","volume":"5","author":"LS King","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1074\/jbc.M411038200","article-title":"cAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells","volume":"280","author":"V Sidhaye","year":"2005","journal-title":"The J of Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/ACI.0000000000000098","article-title":"Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation","volume":"14","author":"DA Dartt","year":"2014","journal-title":"Curr Opin in Allergy and Clin Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"C595","DOI":"10.1152\/ajpcell.2001.281.2.C595","article-title":"Rabbit conjunctival epithelium transports fluid, and P2Y2(2) receptor agonists stimulate Cl(-) and fluid secretion","volume":"281","author":"Y Li","year":"2001","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0187188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T15:42:18Z","timestamp":1570290138000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0187188"}},"subtitle":[],"editor":[{"given":"Wei-Chun","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0187188","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}