{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:40:35Z","timestamp":1776919235849,"version":"3.51.2"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0187269","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T18:28:55Z","timestamp":1510338535000},"page":"e0187269","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spironolactone is effective in treating hypokalemia among peritoneal dialysis patients"],"prefix":"10.1371","volume":"12","author":[{"given":"Amit","family":"Langote","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapnil","family":"Hiremath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Ruzicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-9654","authenticated-orcid":true,"given":"Brendan B.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0272-6386(85)80022-6","article-title":"Potassium supplementation via the dialysate in continuous ambulatory peritoneal dialysis","volume":"6","author":"A Spital","year":"1985","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000182504","article-title":"Continuous ambulatory peritoneal dialysis\u20141981","volume":"30","author":"DG Oreopoulos","year":"1982","journal-title":"Nephron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/089686089601600628","article-title":"Hypokalemia in peritoneal dialysis patients","volume":"16","author":"AN Khan","year":"1996","journal-title":"Perit Dial Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000013418","article-title":"Biochemical parameters, nutritional status and efficiency of dialysis in CAPD and CCPD patients","volume":"19","author":"H Gao","year":"1999","journal-title":"Am J Nephrol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2215\/CJN.00960112","article-title":"Serum potassium and cause-specific mortality in a large peritoneal dialysis cohort","volume":"7","author":"K Torlen","year":"2012","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/039139889702000302","article-title":"Do potassium deficient diets and K+ removal by dialysis contribute to the cardiovascular morbidity and mortality of patients with end stage renal disease?","volume":"20","author":"GM Dolson","year":"1997","journal-title":"Int J Artif Organs"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/ndt\/gfn709","article-title":"Hypokalaemia: an independent risk factor of Enterobacteriaceae peritonitis in CAPD patients","volume":"24","author":"YW Chuang","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/j.ajkd.2005.03.015","article-title":"Hypokalemia in Chinese peritoneal dialysis patients: prevalence and prognostic implication. American journal of kidney diseases: the official journal of the","volume":"46","author":"CC Szeto","year":"2005","journal-title":"National Kidney Foundation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/path.1750","article-title":"Enhanced large intestinal potassium permeability in end-stage renal disease","volume":"206","author":"T Mathialahan","year":"2005","journal-title":"J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/cs0730247","article-title":"Evidence for large intestinal control of potassium homoeostasis in uraemic patients undergoing long-term dialysis","volume":"73","author":"GI Sandle","year":"1987","journal-title":"Clin Sci (Lond)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1681\/ASN.2013030273","article-title":"Long-term effects of spironolactone in peritoneal dialysis patients","volume":"25","author":"Y Ito","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"ref12","first-page":"507","article-title":"A prospective double-blind randomized placebo-controlled clinical trial to evaluate the safety and efficacy of spironolactone in patients with advanced congestive heart failure on continuous ambulatory peritoneal dialysis","volume":"23","author":"S Taheri","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1561-5413(07)60007-6","article-title":"Spironolactone is not Effective for the Treatment of Hypokalemia in Peritoneal Dialysis Patients","volume":"9","author":"JS-S Kwok","journal-title":"Hong Kong Journal of Nephrology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/1744-9987.12219","article-title":"Randomized, Double-Blind, Placebo-Controlled Trial of Spironolactone for Hypokalemia in Continuous Ambulatory Peritoneal Dialysis Patients","volume":"19","author":"S Yongsiri","year":"2015","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3747\/pdi.2016.00022","article-title":"Clinical utility of potassium-sparing diuretics to maintain normal serum potassium in peritoneal dialysis patients","volume":"37","author":"T F\u00fcl\u00f6p","year":"2017","journal-title":"Peritoneal Dialysis International"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.ajkd.2005.03.005","article-title":"Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients","volume":"46","author":"E Gross","year":"2005","journal-title":"American journal of kidney diseases"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jacc.2013.09.056","article-title":"Spironolactone reduces cardiovascular and cerebrovascular morbidity and mortality in hemodialysis patients","volume":"63","author":"Y Matsumoto","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000210553","article-title":"Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients","volume":"114","author":"Y Matsumoto","year":"2009","journal-title":"Cardiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jch.12628","article-title":"Long Term Effects of Low Dose Spironolactone on Chronic Dialysis Patients: A Randomized Placebo Controlled Study","volume":"18","author":"C Lin","year":"2016","journal-title":"The Journal of Clinical Hypertension"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/j.ajkd.2016.04.011","article-title":"The safety and efficacy of mineralocorticoid receptor antagonists in patients who require dialysis: a systematic review and meta-analysis","volume":"68","author":"K Quach","year":"2016","journal-title":"American Journal of Kidney Diseases"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5414\/CN106973","article-title":"Effect of eplerenone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric chronic hemodialysis patients\u2014a pilot study","volume":"76","author":"L Shavit","year":"2011","journal-title":"Clin Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ki.1982.109","article-title":"Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis","volume":"21","author":"MJ Blumenkrantz","year":"1982","journal-title":"Kidney international"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1023\/B:UROL.0000022867.93739.03","article-title":"Prevalence and pathogenesis of hypokalemia in patients on chronic peritoneal dialysis: one center's experience and review of the literature","volume":"35","author":"E Tziviskou","year":"2003","journal-title":"International urology and nephrology"},{"key":"ref24","first-page":"S153","article-title":"Muscle intracellular electrolytes in patients with chronic uremia. Kidney international","volume":"16","author":"J Bergstr\u00f6m","year":"1983","journal-title":"Supplement"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/gut.13.3.197","article-title":"Effect of spironolactone on stool electrolyte losses during human cholera","volume":"13","author":"RL Guerrant","year":"1972","journal-title":"Gut"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrneph.2010.175","article-title":"Pathophysiology and management of hypokalemia: a clinical perspective","volume":"7","author":"RJ Unwin","year":"2011","journal-title":"Nature Reviews Nephrology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/HYPERTENSIONAHA.108.125252","article-title":"Mechanisms of impaired potassium handling with dual renin-angiotensin-aldosterone blockade in chronic kidney disease","volume":"53","author":"RA Preston","year":"2009","journal-title":"Hypertension"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0187269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T16:35:20Z","timestamp":1603298120000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0187269"}},"subtitle":[],"editor":[{"given":"Tatsuo","family":"Shimosawa","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0187269","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]}}}