{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T16:52:39Z","timestamp":1775926359617,"version":"3.50.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD044864"],"award-info":[{"award-number":["R01HD044864"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD079918"],"award-info":[{"award-number":["R01HD079918"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R56AI114013"],"award-info":[{"award-number":["R56AI114013"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R03HD082273"],"award-info":[{"award-number":["R03HD082273"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011123","name":"Academic Health Center, University of Minnesota","doi-asserted-by":"publisher","award":["#16.55 Faculty Research Development Grant Program"],"award-info":[{"award-number":["#16.55 Faculty Research Development Grant Program"]}],"id":[{"id":"10.13039\/100011123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD087496"],"award-info":[{"award-number":["R21HD087496"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["T90DE022732"],"award-info":[{"award-number":["T90DE022732"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007708","name":"Center for Neurobehavioral Development","doi-asserted-by":"publisher","award":["Masonic Neurogenomic and Neuroimaging Research Grant"],"award-info":[{"award-number":["Masonic Neurogenomic and Neuroimaging Research Grant"]}],"id":[{"id":"10.13039\/100007708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0187720","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T17:36:52Z","timestamp":1509730612000},"page":"e0187720","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Assessing Zika virus replication and the development of Zika-specific antibodies after a mid-gestation viral challenge in guinea pigs"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-7409","authenticated-orcid":true,"given":"Craig J.","family":"Bierle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fern\u00e1ndez-Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelmary","family":"Hernandez-Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"Zabeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley C.","family":"Janus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dira S.","family":"Putri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Schleiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1128\/JVI.00252-16","article-title":"Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere","volume":"90","author":"HM Lazear","year":"2016","journal-title":"J Virol"},{"key":"ref2","article-title":"Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","author":"VM Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome\u2014case report, French Polynesia, December 2013","volume":"19","author":"E Oehler","year":"2014","journal-title":"Euro Surveill"},{"key":"ref4","article-title":"Zika Virus Infection in Pregnant Women in Rio de Janeiro\u2014Preliminary Report","author":"P Brasil","year":"2016","journal-title":"N Engl J Med"},{"key":"ref5","article-title":"Zika Virus Associated with Microcephaly","author":"J Mlakar","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"e0004517","DOI":"10.1371\/journal.pntd.0004517","article-title":"Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise","volume":"10","author":"M Sarno","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/AOG.0000000000001625","article-title":"Prolonged Detection of Zika Virus RNA in Pregnant Women","volume":"128","author":"D Meaney-Delman","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.2016.19006","article-title":"Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy","volume":"317","author":"MA Honein","year":"2017","journal-title":"JAMA"},{"key":"ref9","article-title":"Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies","author":"K Best","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1038\/ncomms12204","article-title":"A rhesus macaque model of Asian-lineage Zika virus infection","volume":"7","author":"DM Dudley","year":"2016","journal-title":"Nat Commun"},{"key":"ref11","article-title":"Zika viral dynamics and shedding in rhesus and cynomolgus macaques","author":"CE Osuna","year":"2016","journal-title":"Nat Med"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e1006378","DOI":"10.1371\/journal.ppat.1006378","article-title":"Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques","volume":"13","author":"SM Nguyen","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref13","article-title":"Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate","author":"KM Adams Waldorf","year":"2016","journal-title":"Nat Med"},{"key":"ref14","article-title":"A Mouse Model of Zika Virus Pathogenesis","author":"HM Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"A Grant","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"e1006258","DOI":"10.1371\/journal.ppat.1006258","article-title":"A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses","volume":"13","author":"S Tripathi","year":"2017","journal-title":"PLoS Pathog"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise","volume":"165","author":"JJ Miner","year":"2016","journal-title":"Cell"},{"issue":"7606","key":"ref18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"FR Cugola","year":"2016","journal-title":"Nature"},{"issue":"2","key":"ref19","first-page":"5","article-title":"The guinea-pig placenta","volume":"53","author":"P Kaufmann","year":"1977","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"11\u201312","key":"ref20","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.placenta.2007.08.003","article-title":"Caviomorph placentation as a model for trophoblast invasion","volume":"28","author":"A Mess","year":"2007","journal-title":"Placenta"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/infdis\/138.5.650","article-title":"Experimental congenital infection with cytomegalovirus: a guinea pig model","volume":"138","author":"ML Kumar","year":"1978","journal-title":"J Infect Dis"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/IAI.60.1.271-277.1992","article-title":"Experimental congenital syphilis: guinea pig model","volume":"60","author":"K Wicher","year":"1992","journal-title":"Infect Immun"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/IAI.72.1.489-497.2004","article-title":"Listeriosis in the pregnant guinea pig: a model of vertical transmission","volume":"72","author":"AI Bakardjiev","year":"2004","journal-title":"Infect Immun"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3181\/00379727-70-16892","article-title":"Experimental toxoplasmosis","volume":"70","author":"FH Adams","year":"1949","journal-title":"Proc Soc Exp Biol Med"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","article-title":"Zika virus. II. Pathogenicity and physical properties","volume":"46","author":"GW Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12985-017-0750-4","article-title":"A guinea pig model of Zika virus infection","volume":"14","author":"M Kumar","year":"2017","journal-title":"Virol J"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00500-14","article-title":"Complete coding sequence of zika virus from a French polynesia outbreak in 2013","volume":"2","author":"C Baronti","year":"2014","journal-title":"Genome Announc"},{"issue":"14","key":"ref28","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1128\/JVI.00534-12","article-title":"Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice","volume":"86","author":"J Cox","year":"2012","journal-title":"J Virol"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1371\/journal.ppat.0030132","article-title":"Mosquitoes inoculate high doses of West Nile virus as they probe and feed on live hosts","volume":"3","author":"LM Styer","year":"2007","journal-title":"PLoS Pathog"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.chom.2016.04.021","article-title":"Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes","volume":"19","author":"HL Dutra","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/infdis\/jir014","article-title":"Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status","volume":"203","author":"HT Duyen","year":"2011","journal-title":"J Infect Dis"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1086\/343813","article-title":"High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever","volume":"186","author":"DH Libraty","year":"2002","journal-title":"Journal of Infectious Diseases"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1128\/JVI.07081-11","article-title":"The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model","volume":"86","author":"S Watanabe","year":"2012","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1590\/S0100-736X2016000800013","article-title":"Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)","volume":"36","author":"FMdOe Silva","year":"2016","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"issue":"4","key":"ref35","first-page":"573","article-title":"Reproductive performance and fertility testing in strain 13 and Hartley guinea pigs","volume":"26","author":"RE Doyle","year":"1976","journal-title":"Lab Anim Sci"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.placenta.2015.10.018","article-title":"Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs","volume":"36","author":"Y Xu","year":"2015","journal-title":"Placenta"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1442-200x.2000.01245.x","article-title":"Placental transfer of IgG subclasses in a Japanese population","volume":"42","author":"S Hashira","year":"2000","journal-title":"Pediatr Int"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/aja.1001090205","article-title":"The transfer of serum proteins from mother to young in the guinea pig. I. Prenatal rates and routes","volume":"109","author":"JC Leissring","year":"1961","journal-title":"Am J Anat"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection","volume":"166","author":"LJ Yockey","year":"2016","journal-title":"Cell"},{"issue":"Suppl A","key":"ref40","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"AM Carter","year":"2007","journal-title":"Placenta"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4269\/ajtmh.1952.1.30","article-title":"Research on dengue during World War II","volume":"1","author":"AB Sabin","year":"1952","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1348-0421.1984.tb00709.x","article-title":"&quot;Original antigenic sin&quot; phenomenon in experimental flavivirus infections of guinea pigs: studies by enzyme-linked immunosorbent assay","volume":"28","author":"S Inouye","year":"1984","journal-title":"Microbiology and immunology"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virol.2012.08.005","article-title":"Antagonism of the protein kinase R pathway by the guinea pig cytomegalovirus US22-family gene gp145","volume":"433","author":"CJ Bierle","year":"2012","journal-title":"Virology"},{"issue":"7633","key":"ref44","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature20556","article-title":"Zika virus infection damages the testes in mice","volume":"540","author":"J Govero","year":"2016","journal-title":"Nature"},{"key":"ref45","first-page":"Unit 15D 2","article-title":"Dengue virus: isolation, propagation, quantification, and storage","volume":"Chapter 15","author":"F Medina","year":"2012","journal-title":"Curr Protoc Microbiol"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1086\/382751","article-title":"Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine","volume":"189","author":"MR Schleiss","year":"2004","journal-title":"J Infect Dis"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1677\/joe.0.0510333","article-title":"Concentrations of oestrogen and progesterone in the plasma of non-pregnant, pregnant and lactating guinea-pigs","volume":"51","author":"JR Challis","year":"1971","journal-title":"J Endocrinol"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"RS Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0187720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T02:35:48Z","timestamp":1603247748000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0187720"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Roques","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,3]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0187720","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,3]]}}}