{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:32:11Z","timestamp":1785537131344,"version":"3.56.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung (CH)","award":["143769"],"award-info":[{"award-number":["143769"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0187874","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T13:40:35Z","timestamp":1511790035000},"page":"e0187874","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["A novel registration-based methodology for prediction of trabecular bone fabric from clinical QCT: A comprehensive analysis"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-776X","authenticated-orcid":true,"given":"Vimal","family":"Chandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Zysset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bone.2017.07.012","article-title":"Statistical analysis of the inter-individual variations of the bone shape, volume fraction and fabric and their correlations in the proximal femur","volume":"103","author":"E Taghizadeh","year":"2017","journal-title":"Bone"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s10439-016-1551-4","article-title":"Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration","volume":"44","author":"E Taghizadeh","year":"2016","journal-title":"Ann Biomed Eng"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.jbiomech.2013.07.042","article-title":"A novel approach to estimate trabecular bone anisotropy using a database approach","volume":"46","author":"J Hazrati-Marangalou","year":"2013","journal-title":"J Biomech"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bone.2012.09.006","article-title":"A nonlinear QCT-based finite element model validation study for the human femur tested in two configurations in vitro","volume":"52","author":"E Dall\u2019Ara","year":"2013","journal-title":"Bone"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jmbbm.2014.01.006","article-title":"Orthotropic HR-pQCT-based FE models improve strength predictions for stance but not for side-way fall loading compared to isotropic QCT-based FE models of human femurs","volume":"32","author":"B Luisier","year":"2014","journal-title":"J Mech Behav Biomed Mater"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jbiomech.2015.01.002","article-title":"Statistical estimation of femur micro-architecture using optimal shape and density predictors","volume":"48","author":"K Lekadir","year":"2015","journal-title":"J Biomech"},{"key":"ref7","first-page":"621","article-title":"Prediction of Trabecular Bone Anisotropy from Quantitative Computed Tomography Using Supervised Learning and a Novel Morphometric Feature Descriptor","volume":"9349","author":"V Chandran","year":"2015","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"ref8","article-title":"Including the trabecular anisotropy from registered microCT data in homogenized FE model improves the bone\u2019s mechanical predictions","author":"E Taghizadeh","year":"2014","journal-title":"CMBBE"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.medengphy.2014.09.006","article-title":"Image-based vs mesh-based statistical appearance models of the human femur: Implications for finite element simulations","volume":"36","author":"S Bonaretti","year":"2014","journal-title":"Med Eng Phys"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"S Klein","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1109\/42.796284","article-title":"Nonrigid registration using free-form deformations: application to breast MR images","volume":"18","author":"D Rueckert","year":"1999","journal-title":"IEEE Trans Med Imaging"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the Amount of Ecologic Association Between Species","volume":"26","author":"LR Dice","year":"1945","journal-title":"Ecology"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.acra.2010.06.004","article-title":"Multimodality non-rigid image registration for planning, targeting and monitoring during CT-guided percutaneous liver tumor cryoablation","volume":"17","author":"H Elhawary","year":"2010","journal-title":"Acad Radiol"},{"issue":"4","key":"ref14","first-page":"215","article-title":"Les \u00e9l\u00e9ments al\u00e9atoires de nature quelconque dans un espace distanci\u00e9","volume":"10","author":"M Fr\u00e9chet","year":"1948","journal-title":"Annales de l\u2019institut Henri Poincar\u00e9"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1109\/TMI.2007.906091","article-title":"Generalized tensor-based morphometry of HIV\/AIDS using multivariate statistics on deformation tensors","volume":"27","author":"N Lepore","year":"2008","journal-title":"IEEE Trans Med Imaging"},{"issue":"Suppl 1","key":"ref16","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.neuroimage.2004.07.068","article-title":"Unbiased diffeomorphic atlas construction for computational anatomy","volume":"23","author":"S Joshi","year":"2004","journal-title":"Neuroimage"},{"key":"ref17","first-page":"1","article-title":"Atlas-based image segmentation: A Survey","author":"H Kalinic","year":"2009","journal-title":"Croatian Scientific Bibliography"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/BF00540446","article-title":"Characterization of microstructural anisotropy in orthotropic materials using a second rank tensor","volume":"19","author":"TP Harrigan","year":"1984","journal-title":"Journal of Materials Science"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bone.2009.07.001","article-title":"Assessment of volume fraction and fabric in the distal radius using HR-pQCT","volume":"45","author":"P Varga","year":"2009","journal-title":"Bone"},{"key":"ref20","first-page":"684","article-title":"Multi-contrast diffusion tensor image registration with structural MRI","author":"X Geng","year":"2012","journal-title":"ISBI"},{"issue":"Pt 1","key":"ref21","first-page":"297","article-title":"Towards a statistical atlas of cardiac fiber structure","volume":"9","author":"JM Peyrat","year":"2006","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1109\/TMI.2007.907286","article-title":"A computational framework for the statistical analysis of cardiac diffusion tensors: application to a small database of canine hearts","volume":"26","author":"JM Peyrat","year":"2007","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/10255840802144105","article-title":"From high-resolution CT data to finite element models: development of an integrated modular framework","volume":"12","author":"DH Pahr","year":"2009","journal-title":"Comput Methods Biomech Biomed Engin"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.compmedimag.2005.05.002","article-title":"An anatomic coordinate system of the femoral neck for highly reproducible BMD measurements using 3D QCT","volume":"29","author":"Y Kang","year":"2005","journal-title":"Comput Med Imaging Graph"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1109\/TMI.2003.812265","article-title":"A new accurate and precise 3-D segmentation method for skeletal structures in volumetric CT data","volume":"22","author":"Y Kang","year":"2003","journal-title":"IEEE Trans Med Imaging"},{"key":"ref26","article-title":"Numerical Recipes 3rd Edition: The Art of Scientific Computing","author":"WH Press","year":"2007"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1145\/358669.358692","article-title":"Random sample consensus: a paradigm for model fitting with applications to image analysis and automated cartography","volume":"24","author":"MA Fischler","year":"1981","journal-title":"Communications of the ACM"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s001980200071","article-title":"Hip fracture risk and proximal femur geometry from DXA scans","volume":"13","author":"C Bergot","year":"2002","journal-title":"Osteoporosis International"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10237-014-0584-6","article-title":"A novel approach to estimate trabecular bone anisotropy from stress tensors","volume":"14","author":"J Hazrati Marangalou","year":"2015","journal-title":"Biomech Model Mechanobiol"},{"issue":"Pt 1","key":"ref30","first-page":"77","article-title":"Automatic Construction of 3D Statistical Deformation Models Using Non-rigid Registration","volume":"9","author":"D Rueckert","year":"2001","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"ref31","article-title":"Das Gesetz der Transformation der knochen","author":"J Wolff","year":"1892","journal-title":"AHirchwild"},{"issue":"Pt 2","key":"ref32","first-page":"631","article-title":"Geometry-aware multiscale image registration via OBB Tree-based polyaffine log-demons","volume":"14","author":"C Seiler","year":"2011","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"Pt 2","key":"ref33","first-page":"130","article-title":"Simultaneous Multiscale Polyaffine Registration by Incorporating Deformation Statistics","volume":"15","author":"C Seiler","year":"2012","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"ref34","article-title":"Spatio-Temporal Tensor Decomposition of a Polyaffine Motion Model for a Better Analysis of Pathological Left Ventricular Dynamics","author":"K McLeod","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s10439-015-1432-2","article-title":"Patient-Specific Biomechanical Modeling of Bone Strength Using Statistically-Derived Fabric Tensors","volume":"44","author":"K Lekadir","year":"2016","journal-title":"Ann Biomed Eng"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0187874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:27:14Z","timestamp":1540340834000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0187874"}},"subtitle":[],"editor":[{"given":"Deepak","family":"Vashishth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0187874","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}