{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:41:23Z","timestamp":1781534483962,"version":"3.54.5"},"reference-count":106,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","award":["CBS.MEDBIO.02.10.BH.021"],"award-info":[{"award-number":["CBS.MEDBIO.02.10.BH.021"]}],"id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0188071","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T18:37:10Z","timestamp":1511807830000},"page":"e0188071","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-7469","authenticated-orcid":true,"given":"Anders","family":"Wallqvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nela","family":"Zavaljevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Memi\u0161evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keehwan","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rembert","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seesandra V.","family":"Rajagopala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaques","family":"Reifman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1473-3099(05)70052-9","article-title":"Natural history and pathophysiology of Q fever","volume":"5","author":"D Raoult","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2217\/fmb-2016-0044","article-title":"Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions","volume":"11","author":"CL Larson","year":"2016","journal-title":"Future Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrmicro3049","article-title":"Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii","volume":"11","author":"EJ van Schaik","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q fever to Coxiella burnetii infection: a paradigm change","volume":"30","author":"C Eldin","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1128\/AEM.00042-10","article-title":"Presence of Coxiella burnetii DNA in the environment of the United States, 2006 to 2008","volume":"76","author":"GJ Kersh","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4269\/ajtmh.2006.75.1.0750036","article-title":"National surveillance and the epidemiology of human Q fever in the United States, 1978\u20132004","volume":"75","author":"JH McQuiston","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0140-6736(06)68266-4","article-title":"Q fever","volume":"367","author":"NR Parker","year":"2006","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.prevetmed.2015.06.010","article-title":"Economic aspects of Q fever control in dairy goats","volume":"121","author":"MA van Asseldonk","year":"2015","journal-title":"Prev Vet Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tmaid.2012.11.001","article-title":"Q fever in military and paramilitary personnel in conflict zones: case report and review","volume":"11","author":"B White","year":"2013","journal-title":"Travel Med Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/cmi.12096","article-title":"Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages","volume":"15","author":"JG Graham","year":"2013","journal-title":"Cell Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e51941","DOI":"10.1371\/journal.pone.0051941","article-title":"Resident alveolar macrophages are susceptible to and permissive of Coxiella burnetii infection","volume":"7","author":"M Calverley","year":"2012","journal-title":"PLOS ONE"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2007.00901.x","article-title":"Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii","volume":"9","author":"DE Voth","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref13","article-title":"Contrasting lifestyles within the host cell","volume":"4","author":"EDR Case","year":"2016","journal-title":"Microbiology spectrum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-94-007-4315-1_9","article-title":"Coxiella burnetii secretion systems","volume":"984","author":"JA McDonough","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2180-13-222","article-title":"Sec-mediated secretion by Coxiella burnetii","volume":"13","author":"CM Stead","year":"2013","journal-title":"BMC Microbiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1128\/JB.00071-13","article-title":"Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation","volume":"195","author":"MM Weber","year":"2013","journal-title":"J Bacteriol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e12634","DOI":"10.1111\/cmi.12634","article-title":"Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-\u03b11","volume":"19","author":"W Sch\u00e4fer","year":"2017","journal-title":"Cellular Microbiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/cells5010011","article-title":"Rab GTPases and the autophagy pathway: bacterial targets for a suitable biogenesis and trafficking of their own vacuoles","volume":"5","author":"M L\u00f3pez de Armentia","year":"2016","journal-title":"Cells"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1004286","DOI":"10.1371\/journal.ppat.1004286","article-title":"A Screen of Coxiella burnetii mutants reveals important roles for Dot\/Icm effectors and host autophagy in vacuole biogenesis","volume":"10","author":"HJ Newton","year":"2014","journal-title":"PLoS Pathogens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/cmi.12432","article-title":"Coxiella burnetii: turning hostility into a home","volume":"17","author":"JH Moffatt","year":"2015","journal-title":"Cellular Microbiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"E4770","DOI":"10.1073\/pnas.1309195110","article-title":"Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis","volume":"110","author":"CL Larson","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1006101","DOI":"10.1371\/journal.ppat.1006101","article-title":"The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii","volume":"12","author":"EA Latomanski","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1074\/mcp.M113.029041","article-title":"Novel Burkholderia mallei virulence factors linked to specific host-pathogen protein interactions","volume":"12","author":"V Memisevic","year":"2013","journal-title":"Mol Cell Proteomics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1186\/s12864-015-2351-1","article-title":"Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors","volume":"16","author":"A Wallqvist","year":"2015","journal-title":"BMC Genomics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12859-016-1242-z","article-title":"DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems","volume":"17","author":"V Memisevic","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1004088","DOI":"10.1371\/journal.pcbi.1004088","article-title":"Mining host-pathogen protein interactions to characterize Burkholderia mallei infectivity mechanisms","volume":"11","author":"V Memisevic","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2105-15-244","article-title":"DBSecSys: a database of Burkholderia mallei secretion systems","volume":"15","author":"V Memisevic","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1128\/JB.01532-14","article-title":"Essential role for the response regulator PmrA in Coxiella burnetii type 4B secretion and colonization of mammalian host cells","volume":"196","author":"PA Beare","year":"2014","journal-title":"J Bacteriol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"21755","DOI":"10.1073\/pnas.1010485107","article-title":"Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii","volume":"107","author":"C Chen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1002056","DOI":"10.1371\/journal.ppat.1002056","article-title":"The Coxiella burnetii Dot\/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication","volume":"7","author":"KL Carey","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"E707","DOI":"10.1073\/pnas.1215278110","article-title":"Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal","volume":"110","author":"Z Lifshitz","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1128\/IAI.00207-11","article-title":"PATRIC: the comprehensive bacterial bioinformatics resource with a focus on human pathogenic species","volume":"79","author":"JJ Gillespie","year":"2011","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-5956-8-8","article-title":"Improving the yeast two-hybrid system with permutated fusions proteins: the Varicella Zoster Virus interactome","volume":"8","author":"T Stellberger","year":"2010","journal-title":"Proteome Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-319-23603-2_11","article-title":"Mapping the protein-protein interactome networks using yeast two-hybrid screens","volume":"883","author":"SV Rajagopala","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gks1066","article-title":"Genenames.org: the HGNC resources in 2013","volume":"41","author":"KA Gray","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"D810","DOI":"10.1093\/nar\/gkt1225","article-title":"The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse","volume":"42","author":"JA Blake","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygeno.2006.11.012","article-title":"hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes","volume":"89","author":"P Lamesch","year":"2007","journal-title":"Genomics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"D13","DOI":"10.1093\/nar\/gkr1184","article-title":"Database resources of the National Center for Biotechnology Information","volume":"40","author":"EW Sayers","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"M Kanehisa","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"S Durinck","year":"2005","journal-title":"Bioinformatics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/bioinformatics\/btp167","article-title":"KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor","volume":"25","author":"JD Zhang","year":"2009","journal-title":"Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Stat Soc, Series B (Methodol)"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0167-4838(99)00262-9","article-title":"Calcium-binding EGF-like modules in coagulation proteinases: function of the calcium ion in module interactions","volume":"1477","author":"J Stenflo","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15252\/embr.201439363","article-title":"Exosomes and other extracellular vesicles in host-pathogen interactions","volume":"16","author":"JS Schorey","year":"2015","journal-title":"EMBO Rep"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcimb.2013.00024","article-title":"Metabolic host responses to infection by intracellular bacterial pathogens","volume":"3","author":"W Eisenreich","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mib.2015.09.004","article-title":"Dining in: intracellular bacterial pathogen interplay with autophagy","volume":"29","author":"CG Winchell","year":"2016","journal-title":"Curr Opin Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e00606","DOI":"10.1128\/mBio.00606-12","article-title":"Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening","volume":"4","author":"JA McDonough","year":"2013","journal-title":"MBio"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e12637","DOI":"10.1111\/cmi.12637","article-title":"Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1","volume":"19","author":"AV Justis","year":"2017","journal-title":"L. Cellular Microbiology"},{"key":"ref50","first-page":"107","article-title":"Reorganization of actin cytoskeleton in L929 cells infected with Coxiella burnetii strains isolated from placenta and foetal brain of sheep (Sardinia, Italy)","volume":"51","author":"G Masu","year":"2015","journal-title":"Vet Ital"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1128\/IAI.69.4.2520-2526.2001","article-title":"Activation of protein tyrosine kinases by Coxiella burnetii: role in actin cytoskeleton reorganization and bacterial phagocytosis","volume":"69","author":"S Meconi","year":"2001","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1574-695X.2011.00852.x","article-title":"Effects of Coxiella burnetii on MAPKinases phosphorylation","volume":"64","author":"N Boucherit","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1128\/IAI.00301-09","article-title":"Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii","volume":"77","author":"M Aguilera","year":"2009","journal-title":"Infect Immun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.172.6.3695","article-title":"Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4","volume":"172","author":"A Honstettre","year":"2004","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1128\/IAI.00411-16","article-title":"Murine alveolar macrophages are highly susceptible to replication of Coxiella burnetii phase II in vitro","volume":"84","author":"TD Fernandes","year":"2016","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-10-26","article-title":"Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent","volume":"10","author":"JG Shannon","year":"2009","journal-title":"BMC Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-4939-1261-2_8","article-title":"Hijacking the host proteasome for the temporal degradation of bacterial effectors","volume":"1197","author":"T Kubori","year":"2014","journal-title":"Methods Mol Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1001216","DOI":"10.1371\/journal.ppat.1001216","article-title":"Legionella metaeffector exploits host proteasome to temporally regulate cognate effector","volume":"6","author":"T Kubori","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e0116824","DOI":"10.1371\/journal.pone.0116824","article-title":"The Legionella pneumophila effector protein, LegC7, alters yeast endosomal trafficking","volume":"10","author":"KM O'Brien","year":"2015","journal-title":"PLOS ONE"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ni1528","article-title":"Pathogen subversion of cell-intrinsic innate immunity","volume":"8","author":"CR Roy","year":"2007","journal-title":"Nat Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2007-03-079152","article-title":"Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo","volume":"110","author":"S Bhatnagar","year":"2007","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e80297","DOI":"10.1371\/journal.pone.0080297","article-title":"Identification of TRAPPC8 as a host factor required for human papillomavirus cell entry","volume":"8","author":"Y Ishii","year":"2013","journal-title":"PLOS ONE"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/tra.12180","article-title":"USP8 controls the trafficking and sorting of lysosomal enzymes","volume":"15","author":"E MacDonald","year":"2014","journal-title":"Traffic"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-94-007-4315-1_10","article-title":"Role of lipids in Coxiella burnetii infection","volume":"984","author":"SD Gilk","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1128\/IAI.00863-07","article-title":"Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria","volume":"75","author":"A Luhrmann","year":"2007","journal-title":"Infect Immun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/21505594.2016.1139280","article-title":"The inhibition of the apoptosis pathway by the Coxiella burnetii effector protein CaeA requires the EK repetition motif, but is independent of survivin","volume":"7","author":"S Bisle","year":"2016","journal-title":"Virulence"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/cmi.12066","article-title":"The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level","volume":"15","author":"L Klingenbeck","year":"2013","journal-title":"Cell Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/cmi.12567","article-title":"At the crossroads: communication of bacteria-containing vacuoles with host organelles","volume":"18","author":"JC Santos","year":"2016","journal-title":"Cell Microbiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.micinf.2015.08.006","article-title":"Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii","volume":"17","author":"LJ Kohler","year":"2015","journal-title":"Microbes Infect"},{"key":"ref70","first-page":"e01127","article-title":"Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole","volume":"7","author":"LJ Kohler","year":"2016","journal-title":"mBio"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e0149957","DOI":"10.1371\/journal.pone.0149957","article-title":"Transcriptional profiling of Coxiella burnetii reveals extensive cell wall remodeling in the small cell variant developmental form","volume":"11","author":"KM Sandoz","year":"2016","journal-title":"PLOS ONE"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-94-007-4315-1_12","article-title":"Developmental biology of Coxiella burnetii","volume":"984","author":"MF Minnick","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1002\/pmic.200900282","article-title":"Benchmarking yeast two-hybrid systems using the interactions of bacterial motility proteins","volume":"9","author":"SV Rajagopala","year":"2009","journal-title":"Proteomics"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nmeth0910-667","article-title":"Exhaustive benchmarking of the yeast two-hybrid system","volume":"7","author":"YC Chen","year":"2010","journal-title":"Nat Methods"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1158684","article-title":"High-quality binary protein interaction map of the yeast interactome network","volume":"322","author":"H Yu","year":"2008","journal-title":"Science"},{"key":"ref76","first-page":"M111","article-title":"Categorizing biases in high-confidence high-throughput protein-protein interaction data sets","volume":"10","author":"X Yu","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.mib.2009.06.004","article-title":"Connecting viral with cellular interactomes","volume":"12","author":"SM Bailer","year":"2009","journal-title":"Curr Opin Microbiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"18997","DOI":"10.1073\/pnas.1004380107","article-title":"Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein","volume":"107","author":"A Luhrmann","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1128\/IAI.01204-13","article-title":"Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent trafficking","volume":"82","author":"RA Eckart","year":"2014","journal-title":"Infect Immun"},{"key":"ref80","first-page":"1","article-title":"Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors","author":"T R\u00f6szer","year":"2016","journal-title":"Apoptosis"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"20543","DOI":"10.1074\/jbc.M114.549220","article-title":"Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression","volume":"289","author":"XW Meng","year":"2014","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1095\/biolreprod.114.117481","article-title":"Expression of progesterone receptor membrane component-2 within the immature rat ovary and its role in regulating mitosis and apoptosis of spontaneously immortalized granulosa cells","volume":"91","author":"D Griffin","year":"2014","journal-title":"Biol Reprod"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tcb.2010.05.002","article-title":"Emerging links between CDK cell cycle regulators and Wnt signaling","volume":"20","author":"G Davidson","year":"2010","journal-title":"Trends Cell Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e1004413","DOI":"10.1371\/journal.pgen.1004413","article-title":"Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes","volume":"10","author":"J Hopkins","year":"2014","journal-title":"PLoS Genet"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/nar\/gks1365","article-title":"Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements","volume":"41","author":"P Arampatzi","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.febslet.2013.05.032","article-title":"Does bromodomain flexibility influence histone recognition?","volume":"587","author":"S Steiner","year":"2013","journal-title":"FEBS Lett"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4149\/av_2010_03_173","article-title":"Characterization of antigens for Q fever serodiagnostics","volume":"54","author":"Z Sekeyova","year":"2010","journal-title":"Acta Virol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.micinf.2016.01.003","article-title":"Modulation of the host transcriptome by Coxiella burnetii nuclear effector Cbu1314","volume":"18","author":"MM Weber","year":"2016","journal-title":"Microbes Infect"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e0148032","DOI":"10.1371\/journal.pone.0148032","article-title":"Studying Coxiella burnetii type IV substrates in the yeast Saccharomyces cerevisiae: focus on subcellular localization and protein Aggregation","volume":"11","author":"M Rodriguez-Escudero","year":"2016","journal-title":"PLOS ONE"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-981-10-2041-4_3","article-title":"Cell proliferation and apoptosis in ADPKD","volume":"933","author":"EJ Lee","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/cdd.2014.197","article-title":"The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria","volume":"22","author":"ES Marini","year":"2015","journal-title":"Cell Death Differ"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jcb.22838","article-title":"RTN3 and RTN4: candidate modulators in vascular cell apoptosis and atherosclerosis","volume":"111","author":"Y Chen","year":"2010","journal-title":"J Cell Biochem"},{"key":"ref93","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.01046-16","article-title":"A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection","volume":"85","author":"LF Fielden","year":"2017","journal-title":"Infect Immun"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4161\/cc.10.9.15294","article-title":"JAML and CAR: two more players in T-cell activation","volume":"10","author":"P Verdino","year":"2011","journal-title":"Cell Cycle"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1128\/JB.01359-10","article-title":"The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates","volume":"193","author":"DE Voth","year":"2011","journal-title":"J Bacteriol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.tim.2016.02.003","article-title":"Subversion of retrograde trafficking by translocated pathogen effectors","volume":"24","author":"N Personnic","year":"2016","journal-title":"Trends Microbiol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1091\/mbc.E13-05-0283","article-title":"Nudel\/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis","volume":"24","author":"S Wang","year":"2013","journal-title":"Mol Biol Cell"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nn.2390","article-title":"EFHC1 interacts with microtubules to regulate cell division and cortical development","volume":"12","author":"L de Nijs","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1242\/jcs.171637","article-title":"Characterization of Cep85\u2014a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction","volume":"128","author":"C Chen","year":"2015","journal-title":"J Cell Sci"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejcb.2015.01.004","article-title":"Cep68 can be regulated by Nek2 and SCF complex","volume":"94","author":"X Man","year":"2015","journal-title":"Eur J Cell Biol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1194\/jlr.M700158-JLR200","article-title":"ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity","volume":"48","author":"MA Liz","year":"2007","journal-title":"J Lipid Res"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"160","DOI":"10.14797\/mdcj-11-3-160","article-title":"AIBP: A novel molecule at the Interface of cholesterol transport, angiogenesis, and atherosclerosis","volume":"11","author":"L Zhu","year":"2015","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1073\/pnas.1611956113","article-title":"Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2","volume":"113","author":"X Li","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"e1003107","DOI":"10.1371\/journal.ppat.1003107","article-title":"Bacterial colonization of host cells in the absence of cholesterol","volume":"9","author":"SD Gilk","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.str.2015.08.010","article-title":"Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46","volume":"23","author":"J Yin","year":"2015","journal-title":"Structure"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1074\/jbc.M808430200","article-title":"UAF1 is a subunit of multiple deubiquitinating enzyme complexes","volume":"284","author":"MA Cohn","year":"2009","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0196373","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0188071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T03:07:20Z","timestamp":1719630440000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0188071"}},"subtitle":[],"editor":[{"given":"Zhao-Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":106,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0188071","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0196373","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}