{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:37:29Z","timestamp":1790501849262,"version":"4.1.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0188113","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T17:24:57Z","timestamp":1511371497000},"page":"e0188113","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-521X","authenticated-orcid":true,"given":"Sara","family":"Hestehave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Munro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Br\u00f8nnum Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arvastson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klas S. P.","family":"Abelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.euroneuro.2011.05.005","article-title":"Mechanisms of neuropathic pain","volume":"22","author":"FT Nickel","year":"2012","journal-title":"European Neuropsychopharmacology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00019053-200927020-00002","article-title":"Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy","volume":"27","author":"AB O'Connor","year":"2009","journal-title":"Pharmacoeconomics"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"CA von Hehn","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"ref4","first-page":"1","article-title":"Animal models of neuropathic pain. Fundamental &amp;","volume":"25","author":"AS Jaggi","year":"2011","journal-title":"Clinical Pharmacology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"GJ Bennett","year":"1988","journal-title":"Pain"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Z Seltzer","year":"1990","journal-title":"Pain"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"SH Kim","year":"1992","journal-title":"Pain"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"I Decosterd","year":"2000","journal-title":"Pain"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.aanat.2009.02.007","article-title":"Experimental models of peripheral neuropathic pain based on traumatic nerve injuries\u2014an anatomical perspective","volume":"191","author":"I Klusakova","year":"2009","journal-title":"Annals of Anatomy"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1258\/002367784780891226","article-title":"The relief of pain in laboratory animals","volume":"18","author":"PA Flecknell","year":"1984","journal-title":"Laboratory Animals"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1258\/la.2008.008020","article-title":"Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures","volume":"43","author":"EL Stokes","year":"2009","journal-title":"Laboratory Animals"},{"key":"ref12","first-page":"535","article-title":"Handbook of laboratory animal science, Essential principles and practices. Vol 1","author":"D Morton","year":"2011"},{"issue":"6","key":"ref13","first-page":"61","article-title":"Evaluation of Post-operative Analgesics in a Model of Neuropathic Pain","volume":"37","author":"MD Simkins","year":"1998","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"issue":"1","key":"ref14","first-page":"29","article-title":"Influence of postoperative analgesics on the development of neuropathic pain in rats","volume":"53","author":"LS Stewart","year":"2003","journal-title":"Comparative Medicine"},{"issue":"1\u20132","key":"ref15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0006-8993(92)90570-Y","article-title":"Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat","volume":"570","author":"PM Dougherty","year":"1992","journal-title":"Brain Research"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/00000542-200312000-00025","article-title":"Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block","volume":"99","author":"MR Suter","year":"2003","journal-title":"Anesthesiology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2005.04.017","article-title":"Neuropathic pain: early spontaneous afferent activity is the trigger","volume":"116","author":"W Xie","year":"2005","journal-title":"Pain"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-61779-561-9_15","article-title":"The spared nerve injury model of neuropathic pain","volume":"851","author":"M Pertin","year":"2012","journal-title":"Methods in Molecular Biology"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1258\/0023677011911660","article-title":"Retrospective comparison of rat recovery weights using inhalation and injectable anaesthetics, nutritional and fluid supplementation for right unilateral neurosurgical lesioning","volume":"35","author":"VA Hampshire","year":"2001","journal-title":"Laboratory Animals"},{"issue":"3","key":"ref20","first-page":"335","article-title":"Post-operative corticosterone levels in plasma and feces of mice subjected to permanent catheterization and automated blood sampling","volume":"25","author":"R Sundbom","year":"2011","journal-title":"In Vivo"},{"issue":"2","key":"ref21","first-page":"213","article-title":"Quantitative effects of diet on fecal corticosterone metabolites in two strains of laboratory mice","volume":"26","author":"O Kalliokoski","year":"2012","journal-title":"In Vivo"},{"key":"ref22","article-title":"Handbook of laboratory animal science, Vol 1, Essential principles and practices. Vol 1","author":"L Hellebrekers","year":"2011"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1213\/ane.0b013e31819237f8","article-title":"A Comparison of the Pharmacodynamics and Pharmacokinetics of Bupivacaine, Ropivacaine (with Epinephrine) and Their Equal Volume Mixtures with Lidocaine Used for Femoral and Sciatic Nerve Blocks: A Double-Blind Randomized Study","volume":"108","author":"Nouvellon EMDM Cuvillon PMDM","year":"2009","journal-title":"Anesthesia & Analgesia"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/vr.140.21.553","article-title":"Options for management of acute pain in the rat","volume":"140","author":"FV Abbott","year":"1997","journal-title":"Veterinary Record"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0023677216668553","article-title":"Antinociceptive effects of voluntarily ingested buprenorphine in the hot-plate test in laboratory rats","volume":"51","author":"S Hestehave","year":"2017","journal-title":"Laboratory Animals"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1258\/la.2012.012028","article-title":"Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice","volume":"46","author":"KSP Abelson","year":"2012","journal-title":"Laboratory Animals"},{"issue":"8","key":"ref27","first-page":"500","article-title":"The systemic bioavailability of buprenorphine by various routes of administration. Journal of Pharmacy &amp;","volume":"33","author":"D Brewster","year":"1981","journal-title":"Pharmacology"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1080\/03610929408831436","article-title":"General class of covariance structures for two or more repeated factors in longitudinal data analysis","volume":"23","author":"AT Galecki","year":"1994","journal-title":"Communications in Statistics\u2014Theory and Methods"},{"issue":"Suppl 1","key":"ref29","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/01.j.pain.0000460341.62094.77","article-title":"Social modulation of and by pain in humans and rodents","volume":"156","author":"JS Mogil","year":"2015","journal-title":"Pain"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(79)90002-2","article-title":"Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa","volume":"7","author":"PD Wall","year":"1979","journal-title":"Pain"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1213\/00000539-199377020-00026","article-title":"Preemptive analgesia\u2014treating postoperative pain by preventing the establishment of central sensitization. Anesthesia &amp;","volume":"77","author":"CJ Woolf","year":"1993","journal-title":"Analgesia"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/ACO.0b013e328345afd9","article-title":"Preventive analgesia","volume":"24","author":"JB Dahl","year":"2011","journal-title":"Current Opinion in Anaesthesiology"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pain.2013.10.024","article-title":"Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat","volume":"155","author":"F Yang","year":"2014","journal-title":"Pain"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/bja\/85.4.620","article-title":"Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain","volume":"85","author":"S Abdi","year":"2000","journal-title":"British Journal of Anaesthesia"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuroscience.2004.01.003","article-title":"Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain","volume":"124","author":"DC Broom","year":"2004","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"ref36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3959(02)00039-8","article-title":"Pharmacological characterisation of the spared nerve injury model of neuropathic pain","volume":"98","author":"HK Erichsen","year":"2002","journal-title":"Pain"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(02)02052-6","article-title":"Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury","volume":"450","author":"PF Kouya","year":"2002","journal-title":"European Journal of Pharmacology"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2004.02.007","article-title":"Buprenorphine reduces central sensitization after repetitive C-fiber stimulation in rats","volume":"359","author":"PF Kouya","year":"2004","journal-title":"Neuroscience Letters"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pain.2005.05.004","article-title":"Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain","volume":"116","author":"HK Erichsen","year":"2005","journal-title":"Pain"},{"issue":"1","key":"ref40","first-page":"60","article-title":"Evaluation of buprenorphine in a postoperative pain model in rats","volume":"59","author":"LI Curtin","year":"2009","journal-title":"Comparative Medicine"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0149-2918(04)90171-3","article-title":"A treatment algorithm for neuropathic pain","volume":"26","author":"M Namaka","year":"2004","journal-title":"Clinical Therapeutics"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11916-001-0082-2","article-title":"Pharmacologic treatment of neuropathic pain. Current Pain &amp;","volume":"5","author":"MS Wallace","year":"2001","journal-title":"Headache Reports"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"124898","DOI":"10.1155\/2011\/124898","article-title":"Perioperative nerve blockade: clues from the bench","volume":"2011","author":"MR Suter","year":"2011","journal-title":"Anesthesiology Research and Practice"},{"issue":"Suppl 1","key":"ref44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2044.2010.06241.x","article-title":"Wound infiltration for surgery","volume":"65","author":"NB Scott","year":"2010","journal-title":"Anaesthesia"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3959(95)00077-1","article-title":"Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations","volume":"64","author":"T Mosconi","year":"1996","journal-title":"Pain"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/j.pain.0000000000000838","article-title":"Perioperative pregabalin administration does not prevent chronic postoperative pain: systematic review with a meta-analysis of randomized trials","volume":"158","author":"V Martinez","year":"2017","journal-title":"Pain"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1258\/002367791780808239","article-title":"The effects of surgical procedures, halothane anaesthesia and nalbuphine on locomotor activity and food and water consumption in rats","volume":"25","author":"PA Flecknell","year":"1991","journal-title":"Laboratory Animals"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1080\/17450398209421032","article-title":"Studies on growth, nitrogen and energy metabolism in rats","volume":"32","author":"G Thorbek","year":"1982","journal-title":"Arch Tierernahr"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(97)01345-9","article-title":"Effects of mu- and kappa-opioid receptors on postoperative ileus in rats","volume":"339","author":"BY De Winter","year":"1997","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"ref50","first-page":"G64","article-title":"Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat. American Journal of Physiology\u2014Gastrointestinal &amp;","volume":"289","author":"S Kato","year":"2005","journal-title":"Liver Physiology"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000051876","article-title":"Prostaglandin E inhibits indomethacin-induced gastric lesions through EP-1 receptors","volume":"63","author":"K Suzuki","year":"2001","journal-title":"Digestion"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1677\/joe.0.1800145","article-title":"Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats","volume":"180","author":"F Royo","year":"2004","journal-title":"Journal of Endocrinology"},{"issue":"4","key":"ref53","first-page":"435","article-title":"Corticosterone concentrations in blood and excretion in faeces after ACTH administration in male Sprague-Dawley rats","volume":"22","author":"H Siswanto","year":"2008","journal-title":"In Vivo"},{"issue":"2","key":"ref54","first-page":"131","article-title":"Effects of voluntarily-ingested buprenorphine on plasma corticosterone levels, body weight, water intake, and behaviour in permanently catheterised rats","volume":"24","author":"R Goldkuhl","year":"2010","journal-title":"In Vivo"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1258\/0023677011911822","article-title":"Development and validation of a sensitive ELISA for quantification of secretory IgA in rat saliva and faeces","volume":"35","author":"J Hau","year":"2001","journal-title":"Laboratory Animals"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.rvsc.2006.09.005","article-title":"Quantification of stress sensitive markers in single fecal samples do not accurately predict excretion of these in the pig","volume":"82","author":"HE Carlsson","year":"2007","journal-title":"Research in Veterinary Science"},{"issue":"2","key":"ref57","first-page":"205","article-title":"Body weight and faecal corticosterone metabolite excretion in male Sprague-Dawley rats following short transportation and transfer from group-housing to single-housing","volume":"36","author":"J Dahlin","year":"2009","journal-title":"Scandinavian Journal of Laboratory Animal Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0188113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:30:34Z","timestamp":1540341034000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0188113"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Prunet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0188113","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}