{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:11:26Z","timestamp":1784848286986,"version":"3.55.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health and Labor Sciences Research Grant","award":["251110601"],"award-info":[{"award-number":["251110601"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0188171","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T20:49:38Z","timestamp":1510865378000},"page":"e0188171","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial"],"prefix":"10.1371","volume":"12","author":[{"given":"Hirofumi","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-5605","authenticated-orcid":true,"given":"Daisuke","family":"Ekuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Tomofuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"ref1","unstructured":"Guideline Committee of the Japan Diabetes Society. Japan Diabetes Society evidence-based practice guidelines for the treatment of diabetes in Japan. 2016. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fa.kyorin.co.jp\/jds\/uploads\/GL2016-02.pdf\" xlink:type=\"simple\">http:\/\/www.fa.kyorin.co.jp\/jds\/uploads\/GL2016-02.pdf<\/ext-link>. Cited 12 February 2017."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2337\/dc16-S006","article-title":"3. Foundations of Care and Comprehensive Medical Evaluation","volume":"39","year":"2016","journal-title":"Diabetes Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal disease. The sixth complication of diabetes mellitus","volume":"16","author":"H L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1978.49.5.225","article-title":"Along-termsurvey of tooth loss in 600 treated periodontal patients","volume":"49","author":"L Hirschfeld","year":"1978","journal-title":"J Periodontol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"E Lalla","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/dc09-1378","article-title":"Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis","volume":"33","author":"WJ Teeuw","year":"2010","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e108412","DOI":"10.1371\/journal.pone.0108412","article-title":"The effect of periodontal treatment on hemoglobin a1c levels of diabetic patients: a systematic review and meta-analysis","volume":"9","author":"X Wang","year":"2014","journal-title":"PLoS One"},{"key":"ref8","first-page":"CD004714","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes","volume":"12","author":"TC Simpson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","first-page":"CD004714","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes mellitus","volume":"6","author":"TC Simpson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.bdj.2014.907","article-title":"Diabetes and periodontal disease: a two-way relationship","volume":"217","author":"L Casanova","year":"2014","journal-title":"Br Dent J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1902\/jop.2013.1340013","article-title":"Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence","volume":"84","author":"WS Borgnakke","year":"2013","journal-title":"J Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1902\/jop.2013.1340017","article-title":"Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis","volume":"84","author":"S Engebretson","year":"2013","journal-title":"J Periodontol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/adj.12091","article-title":"Effect of non-surgical periodontal treatment on HbA1c: a meta-analysis of randomized controlled trials","volume":"58","author":"AK Liew","year":"2013","journal-title":"Aust Dent J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.diabet.2008.03.006","article-title":"Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies","volume":"34","author":"L Darr\u00e9","year":"2008","journal-title":"Diabetes Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.4103\/2231-0762.156520","article-title":"Systemic lycopene as an adjunct to scaling and root planing in chronic periodontitis patients with type 2 diabetes mellitus","volume":"5","author":"PV Reddy","year":"2015","journal-title":"J Int Soc Prev Community Dent"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(96)90013-6","article-title":"Oxidative damage to DNA in diabetes mellitus","volume":"347","author":"P Dandona","year":"1996","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1210\/jc.2003-030202","article-title":"Oxidative stress is associated with adiposity and insulin resistance in men","volume":"88","author":"H Urakawa","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"45794","DOI":"10.1155\/2007\/45794","article-title":"Proinflammatory and oxidative stress markers in patients with periodontal disease","volume":"2007","author":"I Borges Jr","year":"2007","journal-title":"Mediators Inflamm"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0757.2006.00178.x","article-title":"The role of reactive oxygen and antioxidant species in periodontal tissue destruction","volume":"43","author":"IL Chapple","year":"2007","journal-title":"Periodontol 2000"},{"key":"ref20","first-page":"255","article-title":"Lipid peroxidation and antioxidant status in patients with periodontitis","volume":"10","author":"K Panjamurthy","year":"2005","journal-title":"Cell Mol Biol Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.freeradbiomed.2009.01.008","article-title":"Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease","volume":"46","author":"H Su","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1902\/jop.2002.73.5.551","article-title":"New biomarker evidence of oxidative DNA damage in whole saliva from clinically healthy and periodontally diseased individuals","volume":"73","author":"M Takane","year":"2002","journal-title":"J Periodontol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nutres.2008.01.008","article-title":"Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance","volume":"28","author":"S Kajiyama","year":"2008","journal-title":"Nutr Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0757.2012.00455.x","article-title":"Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction?","volume":"64","author":"P Bullon","year":"2014","journal-title":"Periodontol 2000"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biom5010194","article-title":"Advanced glycation end products and oxidative stress in type 2 diabetes mellitus","volume":"5","author":"K Nowotny","year":"2015","journal-title":"Biomolecules"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00784-010-0458-y","article-title":"Periodontal treatment decreases plasma oxidized LDL level and oxidative stress","volume":"15","author":"N Tamaki","year":"2011","journal-title":"Clin Oral Investig"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1902\/jop.2013.1340011","article-title":"Diabetes and periodontal diseases: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"84","author":"IL Chapple","year":"2013","journal-title":"J Periodontol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2188\/jea.JE20130131","article-title":"Health-related Quality of Life (HRQOL) Health-related quality of life (HRQOL) decreases independently of chronic conditions and geriatric syndromes in older adults with diabetes: the Fujiwara-kyo Study","volume":"24","author":"S Nezu","year":"2014","journal-title":"J Epidemiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"550","DOI":"10.14310\/horm.2002.1443","article-title":"The prevalence of hypoglycemia and its impact on the quality of life (QoL) of type 2 diabetes mellitus patients (The HYPO Study)","volume":"12","author":"G Rombopoulos","year":"2013","journal-title":"Hormones (Athens)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12955-014-0131-2","article-title":"A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications","volume":"12","author":"N Alcubierre","year":"2014","journal-title":"Health Qual Life Outcomes"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2169\/internalmedicine.50.5107","article-title":"Survey of patient and physician satisfaction regarding patient-centered outpatient consultations in Japan","volume":"50","author":"K Kisa","year":"2011","journal-title":"Intern Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e0145262","DOI":"10.1371\/journal.pone.0145262","article-title":"Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review","volume":"10","author":"CM Santos","year":"2015","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/jcpe.12282","article-title":"Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial","volume":"41","author":"TS Miranda","year":"2014","journal-title":"J Clin Periodontol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"PI Eke","year":"2012","journal-title":"J Periodontol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1001\/jama.2013.282431","article-title":"The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial","volume":"310","author":"SP Engebretson","year":"2013","journal-title":"JAMA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cct.2013.09.010","article-title":"Design features of the Diabetes and Periodontal Therapy Trial (DPTT): a multicenter randomized single-masked clinical trial testing the effect of nonsurgical periodontal therapy on glycosylated hemoglobin (HbA1c) levels in subjects with type 2 diabetes and chronic periodontitis","volume":"36","author":"S Engebretson","year":"2013","journal-title":"Contemp Clin Trials"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-051X.2005.00658.x","article-title":"The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus","volume":"32","author":"M Kiran","year":"2005","journal-title":"J Clin Periodontol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/jcpe.12040","article-title":"Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes: a randomized controlled clinical trial","volume":"40","author":"VR Santos","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3111\/13696998.2012.665111","article-title":"Development and psychometric validation of the Diabetes Therapy-Related QOL (DTR-QOL) questionnaire","volume":"15","author":"H Ishii","year":"2012","journal-title":"J Med Econ"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","article-title":"The plaque control record","volume":"43","author":"T.J. O\u2019Leary","year":"1972","journal-title":"J Periodontol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1902\/jop.2009.080640","article-title":"Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis","volume":"80","author":"N Tamaki","year":"2009","journal-title":"J Periodontol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.2169\/internalmedicine.54.4889","article-title":"Serum Oxidative\/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study","volume":"54","author":"M Terao","year":"2015","journal-title":"Intern Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.fertnstert.2011.11.045","article-title":"Sex-related differences in association of oxidative stress status with coronary artery disease","volume":"97","author":"C Vassalle","year":"2012","journal-title":"Fertil Steril"},{"key":"ref44","unstructured":"Committee for Medicinal Products for Human Use (CHMP). Guideline on Missing Data in Confirmatory Clinical Trials. 2010. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2010\/09\/WC500096793.pdf\" xlink:type=\"simple\">http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2010\/09\/WC500096793.pdf<\/ext-link>. Cited 12 February 2017."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.archoralbio.2010.07.009","article-title":"Influence of glycemic control on Epstein-Bar and Cytomegalovirus infection in periodontal pocket of type 2 diabetic subjects","volume":"55","author":"RC Casarin","year":"2010","journal-title":"Arch Oral Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"908539","DOI":"10.1155\/2014\/908539","article-title":"Oxidative stress and metabolic pathologies: from an adipocentric point of view","volume":"2014","author":"S Le Lay","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12903-016-0249-1","article-title":"The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis","volume":"17","author":"A Teshome","year":"2016","journal-title":"BMC Oral Health"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jebdp.2014.04.017","article-title":"The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems","volume":"14","author":"WS Borgnakke","year":"2014","journal-title":"J Evid Based Dent Pract"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diacare.19.3.257","article-title":"Oxidative stress and diabetic vascular complications","volume":"19","author":"D Giugliano","year":"1996","journal-title":"Diabetes Care"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2337\/db08-0063","article-title":"Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients","volume":"57","author":"A Ceriello","year":"2008","journal-title":"Diabetes"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3390\/antiox4030513","article-title":"Drinking hydrogen-rich water has additive effects on non-surgical periodontal treatment of improving periodontitis: A pilot study","volume":"4","author":"T Azuma","year":"2015","journal-title":"Antioxidants (Basel)"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.archoralbio.2015.05.007","article-title":"The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review","volume":"60","author":"FW Muniz","year":"2015","journal-title":"Arch Oral Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1097\/01.ASN.0000077412.07578.44","article-title":"Effects of antioxidants in diabetes- induced oxidative stress in the glomeruli of diabetic rats","volume":"14","author":"D Koya","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(99)00376-3","article-title":"High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats","volume":"376","author":"PS van Dam","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2337\/diabetes.50.8.1938","article-title":"Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy","volume":"50","author":"RA Kowluru","year":"2001","journal-title":"Diabetes"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"N Houstis","year":"2006","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5051\/jpis.2013.43.4.177","article-title":"Efficacy of nonsurgical periodontal therapy on glycaemic control in type II diabetic patients: a randomized controlled clinical trial","volume":"43","author":"RL Telgi","year":"2013","journal-title":"J Periodontal Implant Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0188171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:07:57Z","timestamp":1589040477000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0188171"}},"subtitle":[],"editor":[{"given":"Binnaz","family":"Leblebicioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0188171","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,16]]}}}