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Global tuberculosis report 2016. 2016."},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"e99880","DOI":"10.1371\/journal.pone.0099880","article-title":"Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV\u2014Kenya, 1998\u20132012","volume":"9","author":"CM Yuen","year":"2014","journal-title":"PloS ONE"},{"issue":"Suppl 1","key":"ref6","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/QAI.0000000000000124","article-title":"Prevalence and incidence of HIV infection, trends, and risk factors among persons aged 15\u201364 years in Kenya: results from a nationally representative study","volume":"66","author":"DO Kimanga","year":"2014","journal-title":"Journal Acquir Immune Defic Syndr"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/CMR.00042-10","article-title":"HIV and tuberculosis: a deadly human syndemic","volume":"24","author":"CK 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tuberculosis: a nested case-control study","volume":"21","author":"M Moosazadeh","year":"2015","journal-title":"Eastern Mediterr Health J"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S1415-790X2009000400001","article-title":"Risk factors associated with death in patients who initiate treatment for tuberculosis after two different follow-up periods","volume":"12","author":"MdFPMd Albuquerque","year":"2009","journal-title":"Rev Bras Epidemiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1186\/1471-2458-11-921","article-title":"The timing of death in patients with tuberculosis who die during anti-tuberculosis treatment in Andhra Pradesh, South India","volume":"11","author":"S Jonnalagada","year":"2011","journal-title":"BMC Public Health"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.5588\/ijtld.12.0135","article-title":"Risk factors for excess mortality and death in adults with tuberculosis in Western Kenya","volume":"16","author":"AH van't Hoog","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref22","article-title":"Treatment of tuberculosis: guidelines","year":"2010"},{"key":"ref23","first-page":"21","article-title":"Guidelines for Management of Tuberculosis and Leprosy in Kenya","year":"2013"},{"key":"ref24","unstructured":"Kipruto H. Assessment of the performance of TB surveillance in Kenya. Multi-country global workshop on TB prevalence surveys and TB surveillance. Accra, Ghana: WHO; 2013."},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cppeds.2008.12.003","article-title":"Diagnosing childhood tuberculosis: traditional and innovative modalities","volume":"39","author":"J Lighter","year":"2009","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"ref26","unstructured":"Measure DHS. Methodology of DHS Mortality Rates Estimation DHS Statistics Live. Calverton, MD, USA: Measure DHS; 2006."},{"key":"ref27","unstructured":"Kenya National Bureau of Statistics. 2009 Kenya Population and Housing Census: Analytical Report on Mortality. Nairobi, Kenya: Kenya National Bureau of Statistics; 2012."},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1183\/09031936.98.11040816","article-title":"Mortality among tuberculosis patients in The Netherlands in the period 1993\u20131995","volume":"11","author":"MW Borgdorff","year":"1998","journal-title":"Eur Respir J"},{"issue":"11","key":"ref29","first-page":"560","article-title":"Excess mortality due to tuberculosis and factors associated to death in and annual cohort of patients diagnosed of tuberculosis","volume":"206","author":"JM Pina","year":"2006","journal-title":"Rev Clin Esp"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2471\/BLT.15.154161","article-title":"Tuberculosis-associated mortality in Shanghai, China: a longitudinal study","volume":"93","author":"W Wang","year":"2015","journal-title":"Bull World Health 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Med"},{"key":"ref34","article-title":"Preventive therapy for latent tuberculosis infection-the promise and the challenges","author":"GJ Fox","year":"2016","journal-title":"Int J Infect Dis"},{"issue":"9323","key":"ref35","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(02)08904-3","article-title":"Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study","volume":"359","author":"M Badri","year":"2002","journal-title":"Lancet"},{"issue":"13","key":"ref36","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1097\/00002030-200009080-00015","article-title":"Impact of combination antiretroviral therapy on the risk of tuberculosis among persons with HIV infection","volume":"14","author":"E Girardi","year":"2000","journal-title":"AIDS"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"e826","DOI":"10.1371\/journal.pone.0000826","article-title":"Impact of antiretroviral therapy on the 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End TB Strategy. 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