{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:11:04Z","timestamp":1790665864875,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08DK094784"],"award-info":[{"award-number":["K08DK094784"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK072482"],"award-info":[{"award-number":["DK072482"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["R464-CR11"],"award-info":[{"award-number":["R464-CR11"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0188497","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T18:19:27Z","timestamp":1512065967000},"page":"e0188497","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-5710","authenticated-orcid":true,"given":"Michael S.","family":"Stalvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Havasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Tuggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Birket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve M.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Sorscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"ref1","unstructured":"Cystic Fibrosis Foundation Patient Registry, 2015 Annual Data Report. Bethesda, MD; 2016."},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.med.0000436191.87727.ec","article-title":"Cystic fibrosis-related bone disease: insights into a growing problem","volume":"20","author":"MS Stalvey","year":"2013","journal-title":"Current opinion in endocrinology, diabetes, and obesity"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jpeds.2015.07.036","article-title":"Comparing the Use of Centers for Disease Control and Prevention and World Health Organization Growth Charts in Children with Cystic Fibrosis through 2 Years of Age","volume":"167","author":"Z Zhang","year":"2015","journal-title":"J Pediatr"},{"key":"ref4","article-title":"Diagnosis by newborn screening in infants with Cystic Fibrosis corrects weight but stunting persists: results from the BONUS cohort study","author":"D Leung","journal-title":"JAMA Pediatrics"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jcf.2016.11.005","article-title":"BMI fails to identify poor nutritional status in stunted children with CF","volume":"16","author":"MW Konstan","year":"2017","journal-title":"J Cyst Fibros"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/JPEM.2009.22.5.417","article-title":"Insulin-like growth factor-I levels predict weight, height and protein catabolism in children and adolescents with cystic fibrosis","volume":"22","author":"M Switzer","year":"2009","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jpeds.2013.02.026","article-title":"Pubertal height velocity and associations with prepubertal and adult heights in cystic fibrosis","volume":"163","author":"Z Zhang","year":"2013","journal-title":"J Pediatr"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1203\/01.pdr.0000196720.25938.be","article-title":"Mouse as a model of growth retardation in cystic fibrosis","volume":"59","author":"LA Rosenberg","year":"2006","journal-title":"Pediatr Res"},{"issue":"47","key":"ref9","doi-asserted-by":"crossref","first-page":"20571","DOI":"10.1073\/pnas.1015281107","article-title":"Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth","volume":"107","author":"MP Rogan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bone.2004.05.021","article-title":"Severe osteopenia in CFTR-null mice","volume":"35","author":"F Dif","year":"2004","journal-title":"Bone"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/rccm.200705-659OC","article-title":"Persistent osteopenia in adult cystic fibrosis transmembrane conductance regulator-deficient mice","volume":"177","author":"CK Haston","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"e80098","DOI":"10.1371\/journal.pone.0080098","article-title":"Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease","volume":"8","author":"MS Stalvey","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"e91253","DOI":"10.1371\/journal.pone.0091253","article-title":"Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats.","volume":"9","author":"KL Tuggle","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"AM Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2106\/00004623-198769020-00002","article-title":"Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth","volume":"69","author":"EB Hunziker","year":"1987","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.clnu.2012.08.017","article-title":"Stunting is an independent predictor of mortality in patients with cystic fibrosis","volume":"32","author":"G Vieni","year":"2013","journal-title":"Clinical nutrition"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ppul.21001","article-title":"Growth and long-term lung function in cystic fibrosis: a longitudinal study of patients diagnosed by neonatal screening","volume":"44","author":"BM Assael","year":"2009","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1067\/mpd.2003.152","article-title":"Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis","volume":"142","author":"MW Konstan","year":"2003","journal-title":"J Pediatr"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-2522","article-title":"Growth in Prepubertal Children With Cystic Fibrosis Treated With Ivacaftor","volume":"139","author":"MS Stalvey","year":"2017","journal-title":"Pediatrics"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.ajpath.2013.12.027","article-title":"Enhanced F508del-CFTR channel activity ameliorates bone pathology in murine cystic fibrosis","volume":"184","author":"C Le Henaff","year":"2014","journal-title":"Am J Pathol"},{"issue":"29","key":"ref21","doi-asserted-by":"crossref","first-page":"18009","DOI":"10.1074\/jbc.M115.646208","article-title":"Increased NF-kappaB Activity and Decreased Wnt\/beta-Catenin Signaling Mediate Reduced Osteoblast Differentiation and Function in DeltaF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mice","volume":"290","author":"C Le Henaff","year":"2015","journal-title":"J Biol Chem"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrendo.2015.165","article-title":"Short and tall stature: a new paradigm emerges","volume":"11","author":"J Baron","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1440-1681.2009.05319.x","article-title":"Functional expression of cystic fibrosis transmembrane conductance regulator in mouse chondrocytes","volume":"37","author":"H Liang","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"Pt 13","key":"ref24","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1113\/jphysiol.2008.150763","article-title":"Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice","volume":"586","author":"E Bonvin","year":"2008","journal-title":"The Journal of physiology"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/rccm.201004-0643OC","article-title":"Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children","volume":"182","author":"DK Meyerholz","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jbmr.359","article-title":"IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP\/Ihh pathway","volume":"26","author":"Y Wang","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"7441","key":"ref27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature11940","article-title":"Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions","volume":"495","author":"KL Cooper","year":"2013","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"235060","DOI":"10.1155\/2014\/235060","article-title":"Effect of GH\/IGF-1 on Bone Metabolism and Osteoporsosis","volume":"2014","author":"V Locatelli","year":"2014","journal-title":"International journal of endocrinology"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ppul.21546","article-title":"A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis","volume":"47","author":"MS Stalvey","year":"2012","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1210\/jc.2009-0570","article-title":"Recombinant insulin-like growth factor (IGF)-I treatment in short children with low IGF-I levels: first-year results from a randomized clinical trial","volume":"95","author":"LK Midyett","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1210\/jcem.87.6.8574","article-title":"Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa","volume":"87","author":"S Grinspoon","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"e105170","DOI":"10.1371\/journal.pone.0105170","article-title":"Growth factor stimulation improves the structure and properties of scaffold-free engineered auricular cartilage constructs","volume":"9","author":"RG Rosa","year":"2014","journal-title":"PLoS One"},{"key":"ref33","article-title":"Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes","author":"J Frisch","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jcf.2010.05.001","article-title":"Osteopenia in Cftr-deltaF508 mice","volume":"9","author":"J Paradis","year":"2010","journal-title":"J Cyst Fibros"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.ajpath.2012.01.039","article-title":"The F508del mutation in cystic fibrosis transmembrane conductance regulator gene impacts bone formation","volume":"180","author":"C Le Henaff","year":"2012","journal-title":"Am J Pathol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"G528","DOI":"10.1152\/ajpgi.00052.2011","article-title":"Cystic fibrosis growth retardation is not correlated with loss of Cftr in the intestinal epithelium","volume":"301","author":"CA Hodges","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1203\/PDR.0b013e3181961e80","article-title":"Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation","volume":"65","author":"TD Pashuck","year":"2009","journal-title":"Pediatr Res"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1210\/en.2007-1581","article-title":"Infertility in females with cystic fibrosis is multifactorial: evidence from mouse models","volume":"149","author":"CA Hodges","year":"2008","journal-title":"Endocrinology"},{"issue":"6","key":"ref39","first-page":"624","article-title":"The Laboratory Rat: Relating Its Age With Human&apos;s","volume":"4","author":"P Sengupta","year":"2013","journal-title":"Int J Prev Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0188497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T10:23:57Z","timestamp":1540203837000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0188497"}},"subtitle":[],"editor":[{"given":"Val\u00e9rie","family":"Geoffroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0188497","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}