{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:16:13Z","timestamp":1790144173575,"version":"4.0.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0188802","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T13:33:30Z","timestamp":1512048810000},"page":"e0188802","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Increased levels of plasma total tau in adult Down syndrome"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-0738","authenticated-orcid":true,"given":"Takashi","family":"Kasai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harutsugu","family":"Tatebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Ohmichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Tung Esther","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Chiyonobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Allsop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"issue":"51","key":"ref1","first-page":"1301","article-title":"Improved national prevalence estimates for 18 selected major birth defects\u2014United States, 1999\u20132001","volume":"54","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"ref2","first-page":"125","article-title":"Down Syndrome: Current Status, Challenges and Future Perspectives","volume":"5","author":"M Kazemi","year":"2016","journal-title":"International journal of molecular and cellular medicine"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S0012162205000319","article-title":"Mortality and causes of death in persons with Down syndrome in California","volume":"47","author":"SM Day","year":"2005","journal-title":"Dev Med Child Neurol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1111\/j.1532-5415.2008.01999.x","article-title":"Survival in elderly persons with Down syndrome","volume":"56","author":"AM Coppus","year":"2008","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0197-4580(89)90073-0","article-title":"Cerebral amyloidosis, ageing and Alzheimer&apos;s disease; a contribution from studies on Down&apos;s syndrome","volume":"10","author":"DM Mann","year":"1989","journal-title":"Neurobiol Aging"},{"issue":"46","key":"ref6","doi-asserted-by":"crossref","first-page":"40401","DOI":"10.1074\/jbc.M111.253971","article-title":"Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation","volume":"286","author":"MS Jung","year":"2011","journal-title":"J Biol Chem"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jnc.13018","article-title":"A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer&apos;s disease: effect on Tau and amyloid pathologies in vitro","volume":"133","author":"S Coutadeur","year":"2015","journal-title":"J Neurochem"},{"issue":"24","key":"ref8","doi-asserted-by":"crossref","first-page":"15219","DOI":"10.1074\/jbc.M115.645507","article-title":"Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE","volume":"290","author":"N Jin","year":"2015","journal-title":"J Biol Chem"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer&apos;s disease: the IWG-2 criteria","volume":"13","author":"B Dubois","year":"2014","journal-title":"Lancet Neurol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410170310","article-title":"Occurrence of neuropathological changes and dementia of Alzheimer&apos;s disease in Down&apos;s syndrome","volume":"17","author":"KE Wisniewski","year":"1985","journal-title":"Ann Neurol"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","article-title":"A prospective study of Alzheimer disease in Down syndrome","volume":"46","author":"F Lai","year":"1989","journal-title":"Arch Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1192\/bjp.172.6.493","article-title":"Population-based study of the prevalence and presentation of dementia in adults with Down&apos;s syndrome","volume":"172","author":"AJ Holland","year":"1998","journal-title":"Br J Psychiatry"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1365-2788.2000.00263.x","article-title":"Incidence and course of dementia in people with Down&apos;s syndrome: findings from a population-based study","volume":"44","author":"AJ Holland","year":"2000","journal-title":"J Intellect Disabil Res"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2788.2006.00842.x","article-title":"Dementia and mortality in persons with Down&apos;s syndrome","volume":"50","author":"A Coppus","year":"2006","journal-title":"J Intellect Disabil Res"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jalz.2015.07.490","article-title":"The pattern of amyloid accumulation in the brains of adults with Down syndrome","volume":"12","author":"T Annus","year":"2016","journal-title":"Alzheimer's & dementia: the journal of the Alzheimer's Association"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fnbeh.2015.00239","article-title":"The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer&apos;s disease biomarkers in down syndrome","volume":"9","author":"MS Rafii","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"ref17","first-page":"290","article-title":"PET imagin of tau deposition in Down syndrome: result from the Down syndrome biomarker initiative (DSBI)","volume":"4","author":"MS Rafii","year":"2016","journal-title":"Jornal of Prevention of Alzheimer's Disease"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000358800","article-title":"Exploring Alzheimer molecular pathology in Down&apos;s syndrome cerebrospinal fluid","volume":"14","author":"E Portelius","year":"2014","journal-title":"Neurodegener Dis"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ana.410410220","article-title":"Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down&apos;s syndrome","volume":"41","author":"T Tokuda","year":"1997","journal-title":"Ann Neurol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.neurobiolaging.2011.08.007","article-title":"Plasma beta amyloid and the risk of Alzheimer&apos;s disease in Down syndrome","volume":"33","author":"AM Coppus","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer&apos;s disease: a systematic review and meta-analysis","volume":"15","author":"B Olsson","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref22","first-page":"316","article-title":"Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer&apos;s Disease","volume":"8","author":"NC Lee","year":"2016","journal-title":"Front Aging Neurosci"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/jamaneurol.2015.1383","article-title":"Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment","volume":"72","author":"A Olivera","year":"2015","journal-title":"JAMA neurology"},{"issue":"17","key":"ref24","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1212\/WNL.0000000000003246","article-title":"Plasma tau in Alzheimer disease","volume":"87","author":"N Mattsson","year":"2016","journal-title":"Neurology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/alzrt163","article-title":"Plasma tau levels in Alzheimer&apos;s disease","volume":"5","author":"H Zetterberg","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"ref26","first-page":"139","article-title":"The developmental characteristics of scoial maturity on children with Down syndrome -using scial maturity scale -revised (S-M)-","volume":"21","author":"H Suzuki","year":"1997","journal-title":"Shinshinshougaigakukenkyu = Bulletin of Disablity Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1192\/bjp.bp.106.024984","article-title":"Dementia screening questionnaire for individuals with intellectual disabilities","volume":"190","author":"S Deb","year":"2007","journal-title":"Br J Psychiatry"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.resuscitation.2012.07.027","article-title":"Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study","volume":"84","author":"J Randall","year":"2013","journal-title":"Resuscitation"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jalz.2016.08.012","article-title":"Neuronal exosomes reveal Alzheimer&apos;s disease biomarkers in Down syndrome","volume":"13","author":"ED Hamlett","year":"2017","journal-title":"Alzheimer's & dementia: the journal of the Alzheimer's Association"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1021\/cn400129p","article-title":"Combined plasma biomarkers for diagnosing mild cognition impairment and Alzheimer&apos;s disease","volume":"4","author":"MJ Chiu","year":"2013","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ddrr.1128","article-title":"Atypical aging in Down syndrome","volume":"18","author":"WB Zigman","year":"2013","journal-title":"Developmental disabilities research reviews"},{"issue":"C","key":"ref32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0074-7750(10)39004-5","article-title":"Health conditions associated with aging and end of life of adults with Down syndrome","volume":"39","author":"AJ Esbensen","year":"2010","journal-title":"International review of research in mental retardation"},{"issue":"21","key":"ref33","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1038\/emboj.2013.220","article-title":"Usp16: key controller of stem cells in Down syndrome","volume":"32","author":"JC Xu","year":"2013","journal-title":"EMBO J"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1371\/journal.pgen.0020050","article-title":"Understanding the basis for Down syndrome phenotypes","volume":"2","author":"RJ Roper","year":"2006","journal-title":"PLoS genetics"},{"issue":"1","key":"ref35","first-page":"99","article-title":"Tau is reduced in AD plasma and validation of employed ELISA methods","volume":"1","author":"DL Sparks","year":"2012","journal-title":"American journal of neurodegenerative disease"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0188802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:06:19Z","timestamp":1588968379000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0188802"}},"subtitle":[],"editor":[{"given":"Stephen D","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0188802","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}