{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:35:16Z","timestamp":1777862116153,"version":"3.51.4"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1140545"],"award-info":[{"award-number":["1140545"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11140580"],"award-info":[{"award-number":["11140580"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1130068"],"award-info":[{"award-number":["1130068"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["3140451"],"award-info":[{"award-number":["3140451"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Millennium Science Initiative (CL)","award":["BNI P-09-015F"],"award-info":[{"award-number":["BNI P-09-015F"]}]},{"DOI":"10.13039\/501100005853","name":"Universidad de Chile","doi-asserted-by":"publisher","award":["U-APOYA 2236"],"award-info":[{"award-number":["U-APOYA 2236"]}],"id":[{"id":"10.13039\/501100005853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189043","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T18:25:04Z","timestamp":1513016704000},"page":"e0189043","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Development of an iron-selective antioxidant probe with protective effects on neuronal function"],"prefix":"10.1371","volume":"12","author":[{"given":"Olimpo","family":"Garc\u00eda-Beltr\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia P.","family":"Mena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pabla","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Barriga-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gald\u00e1mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Nagles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Adasme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-9651","authenticated-orcid":true,"given":"Cecilia","family":"Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco T.","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0039-9140(99)00308-2","article-title":"A flow-through fluorescent sensor to determine Fe(III) and total inorganic iron","volume":"51","author":"P Pulido-Tofino","year":"2000","journal-title":"Talanta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.inoche.2014.06.009","article-title":"A novel colorimetric chemosensor for multiple target ions in aqueous solution: simultaneous detection of Mn(II) and Fe(II)","volume":"46","author":"KB Kim","year":"2014","journal-title":"Inorganic Chemistry Communications"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.5012\/bkcs.2012.33.11.3625","article-title":"Selective Fe2+ Ion Recognition Using a Fluorescent Pyridinyl-benzoimidazole-derived Ionophore","volume":"33","author":"JA Lee","year":"2012","journal-title":"Bulletin of the Korean Chemical Society"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.snb.2013.12.114","article-title":"A single schiff base molecule for recognizing multiple metal ions: A fluorescence sensor for Zn(II) and Al(III) and colorimetric sensor for Fe(II) and Fe(III)","volume":"194","author":"YW Choi","year":"2014","journal-title":"Sensors and Actuators B: Chemical"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1016\/S0021-9258(17)43139-5","article-title":"Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site","volume":"259","author":"E Graf","year":"1984","journal-title":"The Journal of biological chemistry"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1039\/b004231p","article-title":"Fluorimetric determination of iron using 5-(4-methoxyphenylazo)-8-(4-toluenesulfonamido)quinoline","volume":"125","author":"Z Zeng","year":"2000","journal-title":"Analyst"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1373\/49.10.1573","article-title":"Iron deficiency and erythropoiesis: new diagnostic approaches","volume":"49","author":"C Brugnara","year":"2003","journal-title":"Clinical chemistry"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s10534-012-9523-0","article-title":"Iron toxicity in neurodegeneration","volume":"25","author":"MT Nunez","year":"2012","journal-title":"Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"FQ Schafer","year":"2001","journal-title":"Free radical biology & medicine"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/S0021-9258(19)39841-2","article-title":"Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation","volume":"265","author":"P Bergsten","year":"1990","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0887-8994(01)00260-0","article-title":"Systemic iron metabolism: a review and implications for brain iron metabolism","volume":"25","author":"TA Rouault","year":"2001","journal-title":"Pediatric neurology"},{"issue":"4\u20135","key":"ref12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/15216540701222906","article-title":"Calcium, iron and neuronal function","volume":"59","author":"C Hidalgo","year":"2007","journal-title":"IUBMB life"},{"key":"ref13","first-page":"25","article-title":"Brain Iron: Neurochemical and Behavioural Aspects","author":"JM Wigglesworth","year":"1988"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF03033574","article-title":"Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus","volume":"14","author":"MB Youdim","year":"2008","journal-title":"Neurotoxicity research"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbr.2006.04.001","article-title":"Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats","volume":"171","author":"BT Felt","year":"2006","journal-title":"Behavioural brain research"},{"issue":"2s-2","key":"ref16","doi-asserted-by":"crossref","first-page":"649S","DOI":"10.1093\/jn\/131.2.649S","article-title":"A review of studies on the effect of iron deficiency on cognitive development in children","volume":"131","author":"S Grantham-McGregor","year":"2001","journal-title":"The Journal of nutrition"},{"issue":"Suppl 1","key":"ref17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: targets for therapeutics","volume":"139","author":"AA Belaidi","year":"2016","journal-title":"J Neurochem"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0887-8994(01)00303-4","article-title":"Iron and iron management proteins in neurobiology","volume":"25","author":"JR Connor","year":"2001","journal-title":"Pediatric neurology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuro.2010.11.006","article-title":"Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells","volume":"32","author":"GA Salvador","year":"2011","journal-title":"Neurotoxicology"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1089\/ars.2007.1886","article-title":"Crosstalk between calcium and redox signaling: from molecular mechanisms to health implications","volume":"10","author":"C Hidalgo","year":"2008","journal-title":"Antioxidants & redox signaling"},{"issue":"15","key":"ref21","doi-asserted-by":"crossref","first-page":"13382","DOI":"10.1074\/jbc.M110.213785","article-title":"Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity","volume":"286","author":"P Munoz","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"ref22","first-page":"13","article-title":"Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons","volume":"7","author":"CD Sanmartin","year":"2014","journal-title":"Frontiers in molecular neuroscience"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2015.08.009","article-title":"Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells","volume":"337","author":"J Park","year":"2015","journal-title":"Toxicology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2016.07.022","article-title":"Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells","volume":"365","author":"DG Lee","year":"2016","journal-title":"Toxicology"},{"issue":"41","key":"ref25","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1016\/j.tet.2014.08.008","article-title":"Easily accessible ferric ion chemosensor based on rhodamine derivative and its reversible OFF\u2013ON fluorescence response","volume":"70","author":"H Liu","year":"2014","journal-title":"Tetrahedron"},{"key":"ref26","first-page":"1","article-title":"Siderophores from Microorganisms and Plants","author":"JB Neilands","year":"1984"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abio.2002.5611","article-title":"A review of fluorescence methods for assessing labile iron in cells and biological fluids","volume":"304","author":"BP Esposito","year":"2002","journal-title":"Analytical biochemistry"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/jf8030343","article-title":"Exploring Near and Midinfrared Spectroscopy to Predict Trace Iron and Zinc Contents in Powdered Milk","volume":"57","author":"D Wu","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0003-2670(01)83237-2","article-title":"An improved metal extraction procedure for the determination of trace metals in sea water by atomic absorption spectrometry with electrothermal atomization","volume":"98","author":"L-G Danielsson","year":"1978","journal-title":"Analytica Chimica Acta"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/ac202878q","article-title":"Electrochemical Sensors and Biosensors","volume":"84","author":"DW Kimmel","year":"2012","journal-title":"Analytical Chemistry"},{"issue":"48","key":"ref31","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1016\/j.tetlet.2013.09.066","article-title":"Sensing of Fe(III) ion via turn-on fluorescence by fluorescence probes derived from 1-naphthylamine","volume":"54","author":"K Ghosh","year":"2013","journal-title":"Tetrahedron Letters"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jtemb.2016.03.010","article-title":"Iron chelation in the treatment of neurodegenerative diseases","volume":"38","author":"P Dusek","year":"2016","journal-title":"Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)"},{"issue":"22","key":"ref33","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/S0960-894X(98)00578-2","article-title":"Synthesis of novel fluorinated coumarins: Excellent UV-light excitable fluorescent dyes","volume":"8","author":"W-C Sun","year":"1998","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/ol034233h","article-title":"Enzymatic Profiling System in a Small-Molecule Microarray","volume":"5","author":"Q Zhu","year":"2003","journal-title":"Organic Letters"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0047-2670(84)85026-1","article-title":"7-Alkoxy coumarins as fluorescence probes for microenvironments","volume":"26","author":"K Muthuramu","year":"1984","journal-title":"Journal of Photochemistry"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0022-2852(71)90016-6","article-title":"Ultraviolet spectra of coumarins and psoralens","volume":"40","author":"TA Moore","year":"1971","journal-title":"Journal of Molecular Spectroscopy"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1039\/C3RA44843F","article-title":"Coumarin-derived Fe3+-selective fluorescent turn-off chemosensors: synthesis, properties, and applications in living cells","volume":"4","author":"D En","year":"2014","journal-title":"RSC Advances"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mrfmmm.2003.08.004","article-title":"Labile iron pool: the main determinant of cellular response to oxidative stress","volume":"531","author":"M Kruszewski","year":"2003","journal-title":"Mutation research"},{"issue":"8","key":"ref39","first-page":"1037","article-title":"The labile iron pool: characterization, measurement, and participation in cellular processes(1)","volume":"33","author":"O Kakhlon","year":"2002","journal-title":"Free radical biology & medicine"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/jf0502698","article-title":"Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements","volume":"53","author":"RL Prior","year":"2005","journal-title":"J Agric Food Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1039\/a810022e","article-title":"Antioxidant effect of coumarin derivatives on free radical initiated and photosensitized peroxidation of linoleic acid in micelles","volume":"5","author":"W Yu","year":"1999","journal-title":"Journal of the Chemical Society, Perkin Transactions 2"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40360-017-0151-8","article-title":"Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity","volume":"18","author":"D Popova","year":"2017","journal-title":"BMC pharmacology & toxicology"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13024-017-0149-0","article-title":"The SH-SY5Y cell line in Parkinson\u2019s disease research: a systematic review","volume":"12","author":"H Xicoy","year":"2017","journal-title":"Mol Neurodegener"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.redox.2014.12.011","article-title":"Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria","volume":"4","author":"H Zhong","year":"2015","journal-title":"Redox biology"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10534-012-9525-y","article-title":"The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1","volume":"25","author":"P Aguirre","year":"2012","journal-title":"Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1124\/jpet.107.127597","article-title":"Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells","volume":"323","author":"M Watabe","year":"2007","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0006-8993(96)01271-1","article-title":"Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice","volume":"749","author":"K Sriram","year":"1997","journal-title":"Brain research"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-2952(92)90002-Z","article-title":"Interactions of a series of coumarins with reactive oxygen species. Scavenging of superoxide, hypochlorous acid and hydroxyl radicals","volume":"44","author":"M Paya","year":"1992","journal-title":"Biochemical pharmacology"},{"issue":"21","key":"ref49","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1016\/j.bmc.2004.07.066","article-title":"Antioxidant properties of 3-hydroxycoumarin derivatives","volume":"12","author":"F Bailly","year":"2004","journal-title":"Bioorg Med Chem"},{"issue":"13","key":"ref50","doi-asserted-by":"crossref","first-page":"11047","DOI":"10.1074\/jbc.M110.213074","article-title":"Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standards","volume":"286","author":"Z Xiao","year":"2011","journal-title":"The Journal of biological chemistry"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1021\/ja9097324","article-title":"Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor","volume":"132","author":"SV Wegner","year":"2010","journal-title":"Journal of the American Chemical Society"},{"issue":"5415","key":"ref52","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.284.5415.805","article-title":"Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase","volume":"284","author":"TD Rae","year":"1999","journal-title":"Science (New York, NY)"},{"key":"ref53","first-page":"7049108","article-title":"Parkinson\u2019s Disease: The Mitochondria-Iron Link","volume":"2016","author":"Y Munoz","year":"2016","journal-title":"Parkinson\u2019s disease"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1089\/ars.2013.5796","article-title":"Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: potential redox modulation","volume":"21","author":"AC Paula-Lima","year":"2014","journal-title":"Antioxidants & redox signaling"},{"key":"ref55","article-title":"Neuromelanin in Parkinson\u2019s Disease: from Fenton Reaction to Calcium Signaling","author":"R Knorle","year":"2017","journal-title":"Neurotoxicity research"},{"key":"ref56","article-title":"Calcium, mitochondrial dysfunction and slowing the progression of Parkinson\u2019s disease","author":"DJ Surmeier","year":"2017","journal-title":"Experimental neurology"},{"key":"ref57","article-title":"Calcium signaling and molecular mechanisms underlying neurodegenerative diseases","author":"E Pchitskaya","year":"2017","journal-title":"Cell Calcium"},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1089\/ars.2010.3287","article-title":"Amyloid beta-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF","volume":"14","author":"AC Paula-Lima","year":"2011","journal-title":"Antioxidants & redox signaling"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/B:JOFL.0000031828.96368.c1","article-title":"Corrected emission spectra and quantum yields for a series of fluorescent compounds in the visible spectral region","volume":"14","author":"RA Velapoldi","year":"2004","journal-title":"Journal of fluorescence"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1002\/cber.189502803176","article-title":"Darstellung der Ester","volume":"28","author":"E Fischer","year":"1895","journal-title":"Berichte der deutschen chemischen Gesellschaft"},{"issue":"1\u20132","key":"ref61","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1010-6030(00)00240-9","article-title":"Electron transfer from diphenyl and triphenyl amines to excited coumarin dyes","volume":"134","author":"S Nad","year":"2000","journal-title":"Journal of Photochemistry and Photobiology A: Chemistry"},{"issue":"39","key":"ref62","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1016\/j.tetlet.2012.07.082","article-title":"Design and synthesis of a new coumarin-based \u2018turn-on\u2019 fluorescent probe selective for Cu+2","volume":"53","author":"O Garc\u00eda-Beltr\u00e1n","year":"2012","journal-title":"Tetrahedron Letters"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejmech.2013.06.022","article-title":"Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+","volume":"67","author":"O Garcia-Beltran","year":"2013","journal-title":"European journal of medicinal chemistry"},{"issue":"2","key":"ref64","first-page":"513","article-title":"Vitamin E analogue Trolox C. E.s.r. and pulse-radiolysis studies of free-radical reactions","volume":"255","author":"MJ Davies","year":"1988","journal-title":"The Biochemical journal"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bmc.2009.11.053","article-title":"New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems","volume":"18","author":"G Barriga","year":"2010","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/acschemneuro.6b00309","article-title":"Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+\/Cu2+ Chelator in Cell and Animal Models of Parkinson\u2019s Disease","volume":"8","author":"P Aguirre","year":"2017","journal-title":"ACS chemical neuroscience"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0003-2697(90)90208-Q","article-title":"Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples","volume":"190","author":"MA Baker","year":"1990","journal-title":"Analytical biochemistry"},{"issue":"6","key":"ref68","doi-asserted-by":"crossref","first-page":"C2197","DOI":"10.1152\/ajpcell.00620.2006","article-title":"Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells","volume":"292","author":"P Aguirre","year":"2007","journal-title":"American journal of physiology Cell physiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T05:33:25Z","timestamp":1660109605000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189043"}},"subtitle":[],"editor":[{"given":"Yoshiaki","family":"Tsuji","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":68,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189043","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}