{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:06:36Z","timestamp":1766066796458,"version":"3.37.3"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189344","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T14:17:18Z","timestamp":1513088238000},"page":"e0189344","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis"],"prefix":"10.1371","volume":"12","author":[{"given":"Xi-Yuan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-1223","authenticated-orcid":true,"given":"Xiao-Ping","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tox.2008.06.013","article-title":"Hepatic fibrosis\u2014overview","volume":"254","author":"SL Friedman","year":"2008","journal-title":"Toxicology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2005","journal-title":"J Clin Invest"},{"issue":"8","key":"ref3","first-page":"1075","article-title":"Liver fibrosis: a dynamic and potentially reversible process","volume":"25","author":"D Povero","year":"2010","journal-title":"Histol Histopathol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","article-title":"A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat","volume":"5","author":"AM Jezequel","year":"1987","journal-title":"J Hepatol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.bbadis.2012.12.007","article-title":"Strategies for anti-fibrotic therapies","volume":"1832","author":"J Rosenbloom","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13020-015-0066-5","article-title":"Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis","volume":"10","author":"GB Zhang","year":"2015","journal-title":"Chin Med"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jphs.2015.12.002","article-title":"Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro","volume":"130","author":"X Chu","year":"2016","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"ref8","first-page":"122","article-title":"The resources and usage status of the commonly used Tibetan Medicinal Crop \u2018\u2018Dida\u201d","volume":"12","author":"GY Zhong","year":"2010","journal-title":"World Science and Technology\/Modernization of Traditional Chinese Medicine and Materia Medica"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jep.2014.03.058","article-title":"Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo","volume":"153","author":"XY Zheng","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/bj2440075","article-title":"Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat","volume":"244","author":"L Ala-Kokko","year":"1987","journal-title":"Biochem J"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"LC Junqueira","year":"1979","journal-title":"Histochem J"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"BR394","DOI":"10.12659\/MSM.883479","article-title":"Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis","volume":"18","author":"B Wang","year":"2012","journal-title":"Med Sci Monit"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2010.01.013","article-title":"Quantitative proteomics reveals subset-specific viral recognition in dendritic cells","volume":"32","author":"CA Luber","year":"2010","journal-title":"Immunity"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11306-011-0333-0","article-title":"Metabolic profiling of fifteen amino acids in serum of chemical-induced liver injured rats by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry","volume":"8","author":"Y Xu","year":"2012","journal-title":"Metabolomics"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"J Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00795-006-0311-1","article-title":"Angiogenic cell therapy for hepatic fibrosis","volume":"39","author":"T Ueno","year":"2006","journal-title":"Med Mol Morphol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/0253-7613.129323","article-title":"Anti-fibrosis effects of Huisheng oral solution in CCl4-induced hepatic fibrosis in rat","volume":"46","author":"W Li","year":"2014","journal-title":"Indian J Pharmacol"},{"issue":"118","key":"ref18","first-page":"1960","article-title":"Transforming growth factor-beta1 induced epithelial-mesenchymal transition in hepatic fibrosis","volume":"59","author":"WR Bi","year":"2012","journal-title":"Hepatogastroenterology"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/elps.1150191103","article-title":"Proteome and proteomics: new technologies, new concepts, and new words","volume":"19","author":"NL Anderson","year":"1998","journal-title":"Electrophoresis"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.3390\/nu7105434","article-title":"Proteomics Analysis to Identify and Characterize the Molecular Signatures of Hepatic Steatosis in Ovariectomized Rats as a Model of Postmenopausal Status","volume":"7","author":"CC Liao","year":"2015","journal-title":"Nutrients"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/jhep.2000.9322","article-title":"Proteome analysis of rat hepatic stellate cells","volume":"32","author":"DB Kristensen","year":"2000","journal-title":"Hepatology"},{"issue":"27","key":"ref22","doi-asserted-by":"crossref","first-page":"25318","DOI":"10.1074\/jbc.M102630200","article-title":"Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells","volume":"276","author":"N Kawada","year":"2001","journal-title":"J Biol Chem"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.lfs.2003.08.004","article-title":"Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats","volume":"74","author":"G Lu","year":"2004","journal-title":"Life Sci"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1872-034X.2007.00123.x","article-title":"Oral branched-chain amino acid supplementation improves the oxidized\/reduced albumin ratio in patients with liver cirrhosis","volume":"37","author":"H Fukushima","year":"2007","journal-title":"Hepatol Res"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.nutres.2012.06.007","article-title":"Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease","volume":"32","author":"M Kuwahata","year":"2012","journal-title":"Nutr Res"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.3748\/wjg.v20.i10.2515","article-title":"Hepatic inflammation and progressive liver fibrosis in chronic liver disease","volume":"20","author":"AJ Czaja","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"1\u20134","key":"ref27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.foodchem.2012.10.006","article-title":"Protective effects of oligomeric and polymeric procyanidin fractions from defatted grape seeds on tert-butyl hydroperoxide-induced oxidative damage in HepG2 cells","volume":"137","author":"Y Kim","year":"2013","journal-title":"Food Chem"},{"issue":"52","key":"ref28","doi-asserted-by":"crossref","first-page":"43150","DOI":"10.1074\/jbc.M507124200","article-title":"DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity","volume":"280","author":"W Zhou","year":"2005","journal-title":"J Biol Chem"},{"issue":"102\u2013103","key":"ref29","first-page":"1247","article-title":"Increased DJ-1 and its prognostic significance in hepatocellular carcinoma","volume":"57","author":"S Liu","year":"2010","journal-title":"Hepatogastroenterology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.3390\/ijms15069184","article-title":"Molecular mechanisms of liver fibrosis in HIV\/HCV coinfection","volume":"15","author":"CM Mastroianni","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2009.10.011","article-title":"Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis","volume":"36","author":"A Autret","year":"2009","journal-title":"Mol Cell"},{"issue":"1\u20132","key":"ref32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-010-0709-x","article-title":"Role of Bcl-2 family proteins and caspases in the regulation of apoptosis","volume":"351","author":"MS Ola","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0168-8278(86)80089-7","article-title":"Acid-base disturbances in liver disease","volume":"2","author":"JR Oster","year":"1986","journal-title":"J Hepatol"},{"issue":"5 Suppl","key":"ref34","doi-asserted-by":"crossref","first-page":"249S","DOI":"10.1177\/014860719001400518","article-title":"Branched-chain-enriched amino acid solutions in patients with liver failure: an early example of nutritional pharmacology","volume":"14","author":"JE Fischer","year":"1990","journal-title":"JPEN J Parenter Enteral Nutr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:24:42Z","timestamp":1540283082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189344"}},"subtitle":[],"editor":[{"given":"Jordi","family":"Gracia-Sancho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189344","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}