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Technical Report: Update on Lyme disease prevention and control. 2012."},{"key":"ref19","unstructured":"Langley RB. The UTM Grid System. GPS World. 1998;Feb: 46\u201350."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/jmedent\/43.3.600","article-title":"<italic>Ixodes scapularis<\/italic> ticks collected by passive surveillance in Canada: analysis of geographic distribution and infection with Lyme Borreliosis agent <italic>Borrelia burgdorferi<\/italic>","volume":"43","author":"NH Ogden","year":"2006","journal-title":"J Med Entomol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1128\/JCM.42.7.3164-3168.2004","article-title":"Multiplex real-time PCR for detection of <italic>Anaplasma phagocytophilum<\/italic> and <italic>Borrelia burgdorferi<\/italic>","volume":"42","author":"JW Courtney","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1756-3305-7-183","article-title":"The prevalence of <italic>Borrelia miyamotoi<\/italic> infection, and co-infections with other <italic>Borrelia<\/italic> spp. in <italic>Ixodes scapularis<\/italic> ticks collected in Canada","volume":"7","author":"A Dibernardo","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1292\/jvms.71.55","article-title":"<italic>Babesia microti<\/italic>-group parasites compared phylogenetically by complete sequencing of the CCT eta gene in 36 isolates","volume":"55","author":"R Nakajima","year":"2009","journal-title":"J Vet Med Sci"},{"key":"ref24","first-page":"4238","article-title":"Multinomial goodness-of-fit tests for logistic regression models","volume":"27","author":"MW Fagerland","year":"2008"},{"key":"ref25","article-title":"Veterinary Epidemiologic Research","author":"I Dohoo","year":"2009"},{"key":"ref26","unstructured":"Levine N. Chapter 4 Spatial Distribution. In: CrimeStat III User Manual. 3.3. Houston, Texas; 2010. pp. 1\u201340."},{"key":"ref27","author":"N Levine","year":"2010"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jmedent\/36.3.255","article-title":"Microclimate and habitat in relation to <italic>Ixodes scapularis<\/italic> (acari: Ixodidae) populations on Long Point, Ontario, Canada","volume":"36","author":"LR Lindsay","year":"1999","journal-title":"J Med Entomol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jmedent\/36.3.243","article-title":"Abundance of <italic>Ixodes scapularis<\/italic> (acari: Ixodidae) larvae and nymphs in relation to host density and habitat on Long Point, Ontario","volume":"36","author":"LR Lindsay","year":"1999","journal-title":"J Med Entomol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/jmedent\/43.2.403","article-title":"Investigation of ground level and remote-sensed data for habitat classification and prediction of survival of <italic>Ixodes scapularis<\/italic> in habitats of southeastern Canada","volume":"43","author":"NH Ogden","year":"2006","journal-title":"J Med Entomol"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085640","article-title":"Geography, deer, and host biodiversity shape the pattern of Lyme disease emergence in the Thousand Islands archipelago of Ontario, Canada","volume":"9","author":"L Werden","year":"2014","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fcimb.2013.00029","article-title":"Research on the ecology of ticks and tick-borne pathogens\u2014methodological principles and caveats","volume":"3","author":"A Estrada-Pe\u00f1a","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"ref33","article-title":"The forest resources of Ontario","author":"L Watkins","year":"2011"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e105358","DOI":"10.1371\/journal.pone.0105358","article-title":"Population-based passive tick surveillance and detection of expanding foci of blacklegged ticks <italic>Ixodes scapularis<\/italic> and the Lyme disease agent <italic>Borrelia burgdorferi<\/italic> in Ontario, Canada","volume":"9","author":"MP Nelder","year":"2014","journal-title":"PLoS One"},{"key":"ref35","first-page":"494","article-title":"Human Tick infestations in Ontario: findings at the Toronto Public Health Laboratory, 1967\u20131977","volume":"68","author":"T Scholten","year":"1977","journal-title":"Can J Public Heal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10393-010-0287-0","article-title":"Invasion of the Lyme disease vector <italic>Ixodes scapularis<\/italic>: Implications for <italic>Borrelia burgdorferi<\/italic> endemicity","volume":"7","author":"SA Hamer","year":"2010","journal-title":"Ecohealth"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/1756-3305-6-344","article-title":"Ticks in the wrong boxes: assessing error in blanket-drag studies due to occasional sampling","volume":"6","author":"ADM Dobson","year":"2013","journal-title":"Parasit Vectors"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1038\/emi.2015.33","article-title":"Major emerging vector-borne zoonotic diseases of public health importance in Canada","volume":"4","author":"MA Kulkarni","year":"2015","journal-title":"Emerg Microbes Infect"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:20:12Z","timestamp":1570548012000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189393"}},"subtitle":[],"editor":[{"given":"R. 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