{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:30:37Z","timestamp":1778110237349,"version":"3.51.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Internal funding - UAB Depts of Pediatrics and Medicine"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189423","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T13:30:13Z","timestamp":1516368613000},"page":"e0189423","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2528-6976","authenticated-orcid":true,"given":"T. Prescott","family":"Atkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Centor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuchenchu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Van Der Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey D.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Ratliff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Crabb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur H.","family":"Totten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Faircloth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken B.","family":"Waites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7326\/0003-4819-151-11-200912010-00011","article-title":"Expand the pharyngitis paradigm for adolescents and young adults","volume":"151","author":"RM Centor","year":"2009","journal-title":"Ann Intern Med"},{"issue":"Pt 10","key":"ref2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1099\/jmm.0.45648-0","article-title":"Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice","volume":"53","author":"SH Aliyu","year":"2004","journal-title":"J Med Microbiol"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1469-0691.2007.01719.x","article-title":"Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCR","volume":"13","author":"A Jensen","year":"2007","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/09674845.2005.11732687","article-title":"Prevalence of Fusobacterium necrophorum and other upper respiratory tract pathogens isolated from throat swabs","volume":"62","author":"A Batty","year":"2005","journal-title":"Br J Biomed Sci"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/09674845.2007.11732757","article-title":"A six-month audit of the isolation of Fusobacterium necrophorum from patients with sore throat in a district general hospital","volume":"64","author":"JA Amess","year":"2007","journal-title":"Br J Biomed Sci"},{"key":"ref6","first-page":"27","article-title":"A systematic review of Fusobacterium necrophorum-positive acute tonsillitis: prevalence, methods of detection, patient characteristics, and the usefulness of the Centor score","volume":"27","author":"TE Klug","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jinf.2004.09.013","article-title":"Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre&apos;s disease","volume":"51","author":"A Batty","year":"2005","journal-title":"J Infect"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1128\/JCM.02174-16","article-title":"Prevalence of Fusobacterium necrophorum in Children Presenting with Pharyngitis","volume":"55","author":"TT Van","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/M14-1305","article-title":"The Clinical Presentation of Fusobacterium-Positive and Streptococcal-Positive Pharyngitis in a University Health Clinic: A Cross-sectional Study","volume":"162","author":"RM Centor","year":"2015","journal-title":"Ann Intern Med"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1086\/644616","article-title":"Fusobacterium necrophorum: most prevalent pathogen in peritonsillar abscess in Denmark","volume":"49","author":"T Ehlers Klug","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"Suppl 4","key":"ref11","doi-asserted-by":"crossref","first-page":"S292","DOI":"10.1093\/clinids\/16.Supplement_4.S292","article-title":"Bacteriologic findings in peritonsillar abscesses in young adults","volume":"16","author":"H Jousimies-Somer","year":"1993","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1128\/CMR.00011-07","article-title":"Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre&apos;s syndrome","volume":"20","author":"T Riordan","year":"2007","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S1473-3099(12)70089-0","article-title":"Lemierre&apos;s syndrome due to Fusobacterium necrophorum","volume":"12","author":"K Kuppalli","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.anaerobe.2005.11.003","article-title":"Human infections with Fusobacterium necrophorum","volume":"12","author":"JS Brazier","year":"2006","journal-title":"Anaerobe"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/0272989X8100100304","article-title":"The diagnosis of strep throat in adults in the emergency room","volume":"1","author":"RM Centor","year":"1981","journal-title":"Med Decis Making"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"878","DOI":"10.7326\/L15-5100-2","article-title":"Sore Throat: Avoid Overcomplicating the Uncomplicated","volume":"162","author":"JA Linder","year":"2015","journal-title":"Ann Intern Med"},{"issue":"Suppl 1","key":"ref17","first-page":"S37","article-title":"Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. [Review] [66 refs]","volume":"17","author":"HM Foy","year":"1993","journal-title":"Clinical Infectious Diseases"},{"issue":"17","key":"ref18","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"JJ Kozich","year":"2013","journal-title":"Applied and environmental microbiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"18.8.1","DOI":"10.1002\/0471142905.hg1808s82","article-title":"Getting started with microbiome analysis: sample acquisition to bioinformatics","volume":"82","author":"R Kumar","year":"2014","journal-title":"Curr Protoc Hum Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12866-015-0622-2","article-title":"Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile","volume":"16","author":"R Kumar","year":"2016","journal-title":"BMC Microbiol"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/AEM.01996-06","article-title":"Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities","volume":"73","author":"CA Lozupone","year":"2007","journal-title":"Applied and environmental microbiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/B978-0-12-407863-5.00019-8","article-title":"Advancing our understanding of the human microbiome using QIIME","volume":"531","author":"JA Navas-Molina","year":"2013","journal-title":"Methods Enzymol"},{"issue":"19","key":"ref23","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"RC Edgar","year":"2010","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"D McDonald","year":"2012","journal-title":"ISME J"},{"issue":"16","key":"ref25","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Applied and environmental microbiology"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/bioinformatics\/btp636","article-title":"PyNAST: a flexible tool for aligning sequences to a template alignment","volume":"26","author":"JG Caporaso","year":"2010","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1890\/12-2010.1","article-title":"PERMANOVA, ANOSIM, and the Mantel test in the face of heterogeneous dispersions: What null hypothesis are you testing?","volume":"83","author":"MJ Anderson","year":"2013","journal-title":"Ecological Monographs"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1466-8238.2009.00490.x","article-title":"Partitioning the turnover and nestedness components of beta diversity","volume":"19","author":"A Baselga","year":"2010","journal-title":"Global Ecology and Biogeography"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"e56418","DOI":"10.1371\/journal.pone.0056418","article-title":"Molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis","volume":"8","author":"A Jensen","year":"2013","journal-title":"PLoS One"},{"issue":"Pt 9","key":"ref30","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1099\/jmm.0.006718-0","article-title":"Epidemiology of pharyngeal carriage of Fusobacterium necrophorum","volume":"58","author":"H Ludlam","year":"2009","journal-title":"J Med Microbiol"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4269\/ajtmh.16-0581","article-title":"The Human Microbiome in the Fight Against Tuberculosis","volume":"96","author":"MR Wood","year":"2017","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"1335165","DOI":"10.1080\/16512235.2017.1335165","article-title":"Down for the count: Cryptosporidium infection depletes the gut microbiome in Coquerel&apos;s sifakas","volume":"28","author":"EA McKenney","year":"2017","journal-title":"Microb Ecol Health Dis"},{"issue":"10","key":"ref33","first-page":"017","article-title":"Changes in the Intestinal Microbiota of Gibel Carp (Carassius gibelio) Associated with Cyprinid herpesvirus 2 (CyHV-2) Infection","volume":"26","author":"R She","year":"2017","journal-title":"Curr Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T10:42:44Z","timestamp":1540032164000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189423"}},"subtitle":[],"editor":[{"given":"Brenda A","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189423","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]}}}