{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:35:53Z","timestamp":1769243753374,"version":"3.49.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Department of Education, Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases","award":["2015045"],"award-info":[{"award-number":["2015045"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672640"],"award-info":[{"award-number":["81672640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sail plan training high-level personnel project of Guangdong Province","award":["174019"],"award-info":[{"award-number":["174019"]}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"crossref","award":["2014A030313484"],"award-info":[{"award-number":["2014A030313484"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2013B021800174, 2013B021800175"],"award-info":[{"award-number":["2013B021800174, 2013B021800175"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010226","name":"Educational Commission of Guangdong Province","doi-asserted-by":"crossref","award":["2013kjcx0077"],"award-info":[{"award-number":["2013kjcx0077"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shantou University Medical College Clinical Research Enhancement Initiative","award":["2014110109"],"award-info":[{"award-number":["2014110109"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189569","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T18:44:57Z","timestamp":1513277097000},"page":"e0189569","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bone edema on magnetic resonance imaging is highly associated with low bone mineral density in patients with ankylosing spondylitis"],"prefix":"10.1371","volume":"12","author":[{"given":"Danmin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiduo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/1529-0131(199911)42:11<2319::AID-ANR9>3.0.CO;2-G","article-title":"Significant loss of bone mass in patients with early, active ankylosing spondylitis: A followup study","volume":"42","author":"J Gratac\u00f3s","year":"1999","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1136\/ard.2009.124982","article-title":"Bone loss in very early inflammatory back pain in undifferentiated spondyloarthropathy: a 1-year observational study","volume":"69","author":"G Haugeberg","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10067-010-1538-8","article-title":"Low bone mineral density is related to male gender and decreased functional capacity in early spondylarthropathies","volume":"30","author":"MA van der Weijden","year":"2011","journal-title":"Clin Rheumatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1136\/annrheumdis-2012-201845","article-title":"Bone oedema on MRI is highly associated with low bone mineral density in patients with early inflammatory back pain: results from the DESIR cohort","volume":"72","author":"K Briot","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"ref5","first-page":"465","article-title":"Prevalence and risk factors of osteoporosis in patients with ankylosing spondylitis: a 5-year follow-up study of 504 cases","volume":"33","author":"DM Wang","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-014-9867-2","article-title":"Prevalence and risk factors of low bone mineral density in juvenile onset ankylosing spondylitis","volume":"95","author":"Jun Bao","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"ref7","first-page":"1290","article-title":"Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes","volume":"32","author":"K Karberg","year":"2005","journal-title":"J Rheumatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/ard.2009.110767","article-title":"Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI group","volume":"68","author":"M Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/ard.2011.150680","article-title":"Assessment in SpondyloArthritis international Society (ASAS). Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI study group","volume":"71","author":"KG Hermann","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s002560050005","article-title":"Marginal erosive discovertebral \u201cRomanus\u201d lesions in ankylosing spondylitis demonstrated by contrast enhanced Gd-DTPA magnetic resonance imaging","volume":"29","author":"V Jevtic","year":"2000","journal-title":"Skeletal Radiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1186\/ar2035","article-title":"Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis","volume":"8","author":"H Appel","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/ard.59.2.135","article-title":"Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T cells and macrophages predominate in early and active sacroiliitis\u2014cellularity correlates with the degree of enhancement detected by magnetic resonance imaging","volume":"59","author":"M Bollow","year":"2000","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/art.22496","article-title":"Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis","volume":"56","author":"E Jimenez-Boj","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"S Van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1136\/ard.2008.100826","article-title":"ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis","volume":"68","author":"D van der Heijde","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/ard.2006.066415","article-title":"Progression of radiographic damage in patients with ankylosing spondylitis: defining the central role of syndesmophytes","volume":"66","author":"X Baraliakos","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/art.21445","article-title":"Spondyloarthritis research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis","volume":"53","author":"WP Maksymowych","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/art.21337","article-title":"Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis","volume":"53","author":"WP Maksymowych","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"Khaltaev N: The diagnosis of osteoporosis","volume":"9","author":"JA Kanis","year":"1994","journal-title":"J Bone and Mineral Rerearch"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocd.2007.12.002","article-title":"Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference","volume":"11","author":"S Baim","year":"2008","journal-title":"J Clin Densitom"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00296-004-0515-4","article-title":"Ankylosing spondylitis and bone mineral density: what is the ideal tool for measurement?","volume":"26","author":"U Lange","year":"2005","journal-title":"Rheumatol Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"R108","DOI":"10.1186\/ar3833","article-title":"Osteoporosis in ankylosing spondylitis\u2014prevalence, risk factors and methods of assessment","volume":"14","author":"E Klingberg","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref23","first-page":"2740","article-title":"Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis","volume":"127","author":"MA Ulu","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"ref24","first-page":"973","article-title":"Frequency of low bone mineral density in spondyloarthropathy presenting at a tertiary care hospital","volume":"65","author":"L Nazir","year":"2015","journal-title":"J Pak Med Assoc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.semarthrit.2016.03.003","article-title":"Utility of DXA scanning and risk factors for osteoporosis in ankylosing spondylitis-A prospective study","volume":"46","author":"MN Magrey","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10067-012-2018-0","article-title":"High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review","volume":"31","author":"MA van der Weijden","year":"2012","journal-title":"Clin Rheumatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/ard.53.2.117","article-title":"Bone mineral density and vertebral compression fracture rates in ankylosing spondylitis","volume":"53","author":"S1 Donnelly","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00296-012-2632-9","article-title":"Comparison of PA spine, lateral spine, and femoral BMD measurements to determine bone loss in ankylosing spondylitis","volume":"33","author":"MA Ulu","year":"2013","journal-title":"Rheumatol Int"},{"key":"ref29","first-page":"292","article-title":"The association of syndesmophytes with vertebral bone mineral density in patients with ankylosing spondylitis","volume":"32","author":"E Gilgil","year":"2005","journal-title":"J Rheumatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s001980170084","article-title":"Changes in bone density in patients with ankylosing spondylitis: a two year follow-up study","volume":"12","author":"JF Maillefert","year":"2001","journal-title":"Osteoporos Int"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00296-011-2066-9","article-title":"Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study","volume":"32","author":"S Grazio","year":"2012","journal-title":"Rheumatol Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.medici.2015.08.001","article-title":"Factors associated with bone mineral density loss in patients with spondyloarthropathies: A 4-year follow-up study","volume":"51","author":"L Vencevi\u010dien\u0117","year":"2015","journal-title":"Medicina (Kaunas)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/rheumatology\/ket385","article-title":"Evidence for inflammation-induced bone loss in non-radiographic axial spondyloarthritis","volume":"53","author":"G Akg\u00f6l","year":"2014","journal-title":"Rheumatology (Oxford)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T18:29:26Z","timestamp":1589826566000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189569"}},"subtitle":[],"editor":[{"given":"Antony Nicodemus","family":"Antoniou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189569","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}