{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:28:58Z","timestamp":1774906138060,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Leading National Scientific Center","award":["101\/KNOW\/2015"],"award-info":[{"award-number":["101\/KNOW\/2015"]}]},{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","award":["N\/ST\/MN\/16\/001\/1133"],"award-info":[{"award-number":["N\/ST\/MN\/16\/001\/1133"]}],"id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189762","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T18:56:59Z","timestamp":1513364219000},"page":"e0189762","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal plasma angiogenic and inflammatory factor profiling in foetal Down syndrome"],"prefix":"10.1371","volume":"12","author":[{"given":"Monika","family":"Zbucka-Kretowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Charkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Goscik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Wolczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-8198","authenticated-orcid":true,"given":"Piotr","family":"Laudanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mrdd.20157","article-title":"Epidemiology of Down syndrome","volume":"13","author":"SL Sherman","year":"2007","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref2","unstructured":"National Institute of Child Health &amp; Human Development Down syndrome rates 2016 [Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\" xlink:type=\"simple\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/<\/ext-link>."},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/ajmg.a.32932","article-title":"Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populations","volume":"149a","author":"S Ghosh","year":"2009","journal-title":"Am J Med Genet A"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/humrep\/17.3.803","article-title":"Cytokine imbalance in pregnancies with fetal chromosomal abnormalities","volume":"17","author":"F Vesce","year":"2002","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1755-8794-3-40","article-title":"Impairment of circulating endothelial progenitors in Down syndrome","volume":"3","author":"V Costa","year":"2010","journal-title":"BMC Med Genomics"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"371.e1","DOI":"10.1016\/j.ajog.2012.12.035","article-title":"Metabolomic analysis for first-trimester Down syndrome prediction","volume":"208","author":"RO Bahado-Singh","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"e0127732","DOI":"10.1371\/journal.pone.0127732","article-title":"Maternal plasma and amniotic fluid sphingolipids profiling in fetal Down syndrome","volume":"10","author":"K Charkiewicz","year":"2015","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"835837","DOI":"10.1155\/2014\/835837","article-title":"Maternal plasma and amniotic fluid chemokines screening in fetal Down syndrome","volume":"2014","author":"P Laudanski","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.8755-8920.2000.440403.x","article-title":"Abnormal TGFbeta levels in the amniotic fluid of Down syndrome pregnancies","volume":"44","author":"SJ Bromage","year":"2000","journal-title":"Am J Reprod Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"185758","DOI":"10.1155\/2014\/185758","article-title":"Chemokines profiling of patients with preterm birth","volume":"2014","author":"P Laudanski","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref11","article-title":"Amniotic Fluid Angiogenic and Inflammatory Factor Profiling in Foetal Down Syndrome","author":"M Zbucka-Kretowska","year":"2017","journal-title":"Fetal Diagn Ther"},{"issue":"Suppl 1","key":"ref12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/SCS.0b013e3181927f47","article-title":"Role of endogenous angiogenesis inhibitors in Down syndrome","volume":"20","author":"S Ryeom","year":"2009","journal-title":"J Craniofac Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"9362169","DOI":"10.1155\/2016\/9362169","article-title":"Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome","volume":"2016","author":"K Charkiewicz","year":"2016","journal-title":"J Immunol Res"},{"key":"ref14","article-title":"Angiogenic factor screening in women with mild preeclampsia\u2014New and significant proteins in plasma","author":"K Charkiewicz","year":"2017","journal-title":"Cytokine"},{"key":"ref15","first-page":"562","article-title":"Identification of proteomic biomarkers of preeclampsia using protein microarray and tandem mass spectrometry","volume":"69","author":"K Charkiewicz","year":"2015","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"ref16","unstructured":"Shapiro SS, Francia RS. An Approximate Analysis of Variance Test for Normality. 2012."},{"key":"ref17","first-page":"278","article-title":"Robust tests for equality of variances","volume":"1","author":"H Levene","year":"1960","journal-title":"Contributions to Probability and Statistics: Essays in Honor of Harold Hotelling"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"e0159005","DOI":"10.1371\/journal.pone.0159005","article-title":"Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension","volume":"11","author":"C Galambos","year":"2016","journal-title":"PLoS One"},{"issue":"18","key":"ref19","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1158\/1078-0432.CCR-07-1157","article-title":"Transforming growth factor-beta and the immune response: implications for anticancer therapy","volume":"13","author":"SH Wrzesinski","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1365-2141.2001.03093.x","article-title":"High expression of platelet-derived growth factor and transforming growth factor-beta 1 in blast cells from patients with Down Syndrome suffering from transient myeloproliferative disorder and organ fibrosis","volume":"115","author":"H Hattori","year":"2001","journal-title":"Br J Haematol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00001756-199301000-00018","article-title":"Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies","volume":"4","author":"EA van der Wal","year":"1993","journal-title":"Neuroreport"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/jcb.240530408","article-title":"TGF-beta 1 is an organizer of responses to neurodegeneration","volume":"53","author":"CE Finch","year":"1993","journal-title":"J Cell Biochem"},{"issue":"2\u20133","key":"ref23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/plac.2000.0598","article-title":"Placental and maternal serum inhibin-A and activin-A levels in Down&apos;s syndrome pregnancies","volume":"22","author":"GL Dalgliesh","year":"2001","journal-title":"Placenta"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpeds.2016.08.063","article-title":"Prominent Intrapulmonary Bronchopulmonary Anastomoses and Abnormal Lung Development in Infants and Children with Down Syndrome","volume":"180","author":"D Bush","year":"2017","journal-title":"J Pediatr"},{"key":"ref25","first-page":"859","article-title":"Differential conversion of plasminogen to angiostatin by human corneal cell populations","volume":"11","author":"DJ Warejcka","year":"2005","journal-title":"Mol Vis"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0002-9149(99)00864-4","article-title":"Plasminogen activator inhibitor type 1 in adults with Down syndrome and protection against macrovascular disease","volume":"85","author":"WE Hopkins","year":"2000","journal-title":"Am J Cardiol"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/clinchem\/44.2.205","article-title":"Increased concentrations of prostate-specific antigen in maternal serum from pregnancies affected by fetal Down syndrome","volume":"44","author":"GM Lambert-Messerlian","year":"1998","journal-title":"Clin Chem"},{"key":"ref28","unstructured":"VEGFD vascular endothelial growth factor D [Homo sapiens (human)]\u2014Gene\u2014NCBI: Pubs; 2016 [Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\" xlink:type=\"simple\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/<\/ext-link>."},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbrc.2004.06.176","article-title":"VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis?","volume":"321","author":"YG Yao","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/hmg\/9.11.1681","article-title":"DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways","volume":"9","author":"JJ Fuentes","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"7250","key":"ref31","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nature08062","article-title":"Down&apos;s syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1","volume":"459","author":"KH Baek","year":"2009","journal-title":"Nature"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1182\/blood.V96.13.4039","article-title":"I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo","volume":"96","author":"G Bernardini","year":"2000","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T10:30:02Z","timestamp":1603535402000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189762"}},"subtitle":[],"editor":[{"given":"Rudolf","family":"Kirchmair","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,15]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189762","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,15]]}}}