{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:19:20Z","timestamp":1790036360444,"version":"4.0.1"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Institute for Regenerative Medicine","award":["NIRM1.7"],"award-info":[{"award-number":["NIRM1.7"]}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["nhs2009B063"],"award-info":[{"award-number":["nhs2009B063"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0189805","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T18:33:52Z","timestamp":1513622032000},"page":"e0189805","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-9907","authenticated-orcid":true,"given":"Calinda K. E.","family":"Dingenouts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wineke","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Lodder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karien C.","family":"Wiesmeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asja T.","family":"Moerkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janita A.","family":"Maring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke M.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9","family":"Goumans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/sj.emboj.7600386","article-title":"Endoglin promotes endothelial cell proliferation and TGF-\u03b2\/ALK1 signal transduction","volume":"23","author":"F Lebrin","year":"2004","journal-title":"The EMBO Journal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1050-1738(03)00142-7","article-title":"Controlling the Angiogenic SwitchA Balance between Two Distinct TGF-b Receptor Signaling Pathways","volume":"13","author":"M-J Goumans","year":"2003","journal-title":"Trends in Cardiovascular Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI8088","article-title":"A murine model of hereditary hemorrhagic telangiectasia","volume":"104","author":"A Bourdeau","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.1999.9534","article-title":"Endoglin, an Ancillary TGF\u03b2 Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development","volume":"217","author":"HM Arthur","year":"2000","journal-title":"Developmental Biology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/S0002-9440(10)64673-1","article-title":"Potential Role of Modifier Genes Influencing Transforming Growth Factor-\u03b21 Levels in the Development of Vascular Defects in Endoglin Heterozygous Mice with Hereditary Hemorrhagic Telangiectasia","volume":"158","author":"A Bourdeau","year":"2001","journal-title":"The American Journal of Pathology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cardiores.2005.11.020","article-title":"Reduced angiogenic responses in adult Endoglin heterozygous mice","volume":"69","author":"M Jerkic","year":"2006","journal-title":"Cardiovascular research"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1111\/j.1582-4934.2012.01561.x","article-title":"Shear induced collateral artery growth modulated by endoglin but not by ALK1","volume":"16","author":"L Seghers","year":"2012","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1152\/ajpheart.01251.2009","article-title":"The physiological role of endoglin in the cardiovascular system","volume":"299","author":"JM L\u00f3pez-novoa","year":"2010","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e86273","DOI":"10.1371\/journal.pone.0086273","article-title":"ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis","volume":"9","author":"Z Liu","year":"2014","journal-title":"PLoS ONE"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/VHRM.S29144","article-title":"Endoglin: a critical mediator of cardiovascular health","volume":"9","author":"N Kapur","year":"2013","journal-title":"Vascular Health and Risk Management"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2013.07.057","article-title":"Macrophage subpopulations are essential for infarct repair with and without stem cell therapy","volume":"62","author":"T Ben-Mordechai","year":"2013","journal-title":"Journal of the American College of Cardiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"M Nahrendorf","year":"2007","journal-title":"The Journal of experimental medicine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2353\/ajpath.2007.060547","article-title":"Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice","volume":"170","author":"MJ van Amerongen","year":"2007","journal-title":"The American journal of pathology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1161\/CIRCULATIONAHA.106.639161","article-title":"Endoglin Has a Crucial Role in Blood Cell-Mediated Vascular Repair","volume":"114","author":"LW van Laake","year":"2006","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/cvr\/cvp313","article-title":"Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4\/CD26 balance","volume":"85","author":"S Post","year":"2010","journal-title":"Cardiovascular Research"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(03)14232-8","article-title":"Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy","volume":"362","author":"AT Askari","year":"2003","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"10","author":"DJ Ceradini","year":"2004","journal-title":"Nature medicine"},{"key":"ref18","first-page":"195","article-title":"DPP-4 Inhibition by Sitagliptin Improves the Myocardial Response to Dobutamine Stress and Mitigates Stunning in a Pilot Study of Patients With Coronary Artery Disease","volume":"3","author":"PA Read","year":"2010","journal-title":"Circulation: Cardiovascular Imaging"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2337\/dc10-1393","article-title":"Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database","volume":"34","author":"JH Best","year":"2011","journal-title":"Diabetes care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/FJC.0b013e31821e5626","article-title":"DPP-4 (CD26) Inhibitor Alogliptin Inhibits Atherosclerosis in Diabetic Apolipoprotein E\u2013Deficient Mice","volume":"58","author":"NN Ta","year":"2011","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.2337\/dc10-0187","article-title":"The Oral Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Increases Circulating Endothelial Progenitor Cells in Patients With Type 2 Diabetes: Possible role of stromal-derived factor-1","volume":"33","author":"GP Fadini","year":"2010","journal-title":"Diabetes Care"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijcard.2015.07.044","article-title":"DPP-4 inhibition ameliorates atherosclerosis by priming monocytes into M2 macrophages","volume":"199","author":"C Brenner","year":"2015","journal-title":"International Journal of Cardiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10753-015-0263-5","article-title":"The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8\/9 Inhibition Attenuates M1 Macrophage Activation in Mice","volume":"39","author":"Y Waumans","year":"2016","journal-title":"Inflammation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e88511","DOI":"10.1371\/journal.pone.0088511","article-title":"Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia","volume":"9","author":"E-J Choi","year":"2014","journal-title":"PloS one"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"BE Clausen","year":"1999","journal-title":"Transgenic Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.yjmcc.2015.02.007","article-title":"Cardiac endothelial cells express Wilms&apos; tumor-1. Wt1 expression in the developing, adult and infarcted heart","volume":"81","author":"SN Duim","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1161\/CIRCRESAHA.116.309001","article-title":"Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure","volume":"119","author":"HB Sager","year":"2016","journal-title":"Circulation Research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"A Mantovani","year":"2013","journal-title":"The Journal of pathology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cvr\/cvu025","article-title":"Cardiac macrophages and their role in ischemic heart disease","volume":"102","author":"S Frantz","year":"2014","journal-title":"Cardiovascular research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/ATVBAHA.114.303984","article-title":"Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models\u2014brief report","volume":"34","author":"EM Garrido-Martin","year":"2014","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood-2012-06-435347","article-title":"Endothelial endoglin is involved in inflammation: Role in leukocyte adhesion and transmigration","volume":"121","author":"E Rossi","year":"2013","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/767185","article-title":"Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis","volume":"2014","author":"MR Peter","year":"2014","journal-title":"Mediators of Inflammation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.yjmcc.2012.08.026","article-title":"Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction","volume":"53","author":"S Post","year":"2012","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref34","first-page":"351","article-title":"Immunological abnormalities associated with hereditary haemorrhagic telangiectasia","author":"A Guilhem","year":"2013","journal-title":"Immunological abnormalities associated with hereditary haemorrhagic telangiectasia"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1373\/clinchem.2004.035287","article-title":"Mutation analysis in Spanish patients with hereditary hemorrhagic telangiectasia: deficient endoglin up-regulation in activated monocytes","volume":"50","author":"F Sanz-Rodriguez","year":"2004","journal-title":"Clinical chemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"A Sindrilaru","year":"2011","journal-title":"Journal of Clinical Investigation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/jcs.143644","article-title":"Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization","volume":"127","author":"M Aristorena","year":"2014","journal-title":"Journal of cell science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1005935","DOI":"10.1371\/journal.pgen.1005935","article-title":"Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response","volume":"12","author":"L Ojeda-Fern\u00e1ndez","year":"2016","journal-title":"PLOS Genetics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/ndt\/gfl179","article-title":"Endoglin regulates renal ischaemia-reperfusion injury","volume":"21","author":"NG Docherty","year":"2006","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1210\/en.2012-1855","article-title":"Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice","volume":"154","author":"N Ervinna","year":"2013","journal-title":"Endocrinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00386","article-title":"DPP4 in diabetes","volume":"6","author":"D R\u00f6hrborn","year":"2015","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1152\/ajpendo.00553.2014","article-title":"DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappaB activation","volume":"309","author":"T Shinjo","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1161\/CIRCULATIONAHA.111.041418","article-title":"Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis","volume":"124","author":"Z Shah","year":"2011","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e005752","DOI":"10.1136\/bmjopen-2014-005752","article-title":"Safety and effectiveness of dipeptidyl peptidase-4 inhibitors versus intermediate-acting insulin or placebo for patients with type 2 diabetes failing two oral antihyperglycaemic agents: a systematic review and network meta-analysis","volume":"4","author":"AC Tricco","year":"2014","journal-title":"BMJ Open"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ijcard.2014.09.016","article-title":"Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells","volume":"177","author":"C Brenner","year":"2014","journal-title":"International journal of cardiology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/eurheartj\/ehr302","article-title":"Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes","volume":"33","author":"M-M Zaruba","year":"2012","journal-title":"European Heart Journal"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.scr.2011.05.003","article-title":"Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1\/CXCR4 axis","volume":"7","author":"HD Theiss","year":"2011","journal-title":"Stem Cell Research"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00018-015-2099-4","article-title":"Endoglin regulates mural cell adhesion in the circulatory system","volume":"73","author":"E Rossi","year":"2016","journal-title":"Cellular and Molecular Life Sciences"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nm.2131","article-title":"Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia","volume":"16","author":"F Lebrin","year":"2010","journal-title":"Nature Medicine"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1002\/dvdy.22066","article-title":"Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis","volume":"238","author":"ML Mancini","year":"2009","journal-title":"Developmental Dynamics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2015.07.005","article-title":"Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation","volume":"73","author":"SH Choi","year":"2015","journal-title":"Vascular Pharmacology"},{"key":"ref52","first-page":"59","article-title":"Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice","author":"M Sauve","year":"2010","journal-title":"Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2009.02.013","article-title":"Synergy between CD26\/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction","volume":"4","author":"M-M Zaruba","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijcard.2015.11.180","article-title":"Sitagliptin plus granulocyte colony-stimulating factor in patients suffering from acute myocardial infarction: A double-blind, randomized placebo-controlled trial of efficacy and safety (SITAGRAMI trial)","volume":"205","author":"C Brenner","year":"2016","journal-title":"International Journal of Cardiology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ijcard.2016.04.134","article-title":"Combined therapy with sitagliptin plus granulocyte-colony stimulating factor in patients with acute myocardial infarction\u2014Long-term results of the SITAGRAMI trial","volume":"215","author":"L Gross","year":"2016","journal-title":"International Journal of Cardiology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2014.12.017","article-title":"Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis","volume":"181","author":"G Savarese","year":"2015","journal-title":"International Journal of Cardiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1161\/CIRCRESAHA.116.305665","article-title":"DPP4 in Cardiometabolic Disease: Recent Insights From the Laboratory and Clinical Trials of DPP4 Inhibition","volume":"116","author":"J Zhong","year":"2015","journal-title":"Circulation Research"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3810\/pgm.2010.05.2138","article-title":"A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes","volume":"122","author":"R Frederich","year":"2010","journal-title":"Postgraduate medicine"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.amjcard.2012.04.061","article-title":"Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus","volume":"110","author":"HR Patil","year":"2012","journal-title":"The American journal of cardiology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2840-11-6","article-title":"Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data","volume":"11","author":"ME Cobble","year":"2012","journal-title":"Cardiovascular Diabetology"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1479164114562411","article-title":"Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes","volume":"12","author":"J Koska","year":"2015","journal-title":"Diab Vasc Dis Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ki.2015.103","article-title":"Interactions of DPP-4 and integrin \u03b21 influences endothelial-to-mesenchymal transition","volume":"88","author":"S Shi","year":"2015","journal-title":"Kidney International"},{"issue":"6232","key":"ref63","doi-asserted-by":"crossref","first-page":"aaa2151","DOI":"10.1126\/science.aaa2151","article-title":"Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential","volume":"348","author":"Y Rinkevich","year":"2015","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/sj.jid.5701104","article-title":"Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts","volume":"128","author":"A Thielitz","year":"2007","journal-title":"Journal of Investigative Dermatology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yjmcc.2016.01.021","article-title":"The Prospective Cardioprotective Effects of DPP-4 inhibition in the ischemic myocardium","volume":"93","author":"GA Grilo","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"ref66","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1111\/bph.13274","article-title":"Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression","volume":"172","author":"HJ Choi","year":"2015","journal-title":"Br J Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"H1528","DOI":"10.1152\/ajpheart.00070.2015","article-title":"NPY 1\u201336 and PYY 1\u201336 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4","volume":"309","author":"X Zhu","year":"2015","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e0141143","DOI":"10.1371\/journal.pone.0141143","article-title":"Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGF\u00df through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin","volume":"10","author":"M Gangadharan Komala","year":"2015","journal-title":"Plos One"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.2337\/db13-1029","article-title":"Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen","volume":"63","author":"K Kanasaki","year":"2014","journal-title":"Diabetes"},{"key":"ref70","first-page":"1","article-title":"DPP4 Inhibition in Human Kidney Proximal Tubular Cells\u2014Renoprotection in Diabetic Nephropathy?","volume":"S9","author":"U Panchapakesan","year":"2013","journal-title":"Journal of Diabetes & Metabolism"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0189805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:06:45Z","timestamp":1589004405000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0189805"}},"subtitle":[],"editor":[{"given":"Johnson","family":"Rajasingh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0189805","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]}}}