{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:21:49Z","timestamp":1792203709164,"version":"4.4.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190205","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T19:57:45Z","timestamp":1514923065000},"page":"e0190205","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":76,"title":["The effects of exercise on hypothalamic neurodegeneration of Alzheimer\u2019s disease mouse model"],"prefix":"10.1371","volume":"13","author":[{"given":"Khoa","family":"Do","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenton Thomas","family":"Laing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyatt","family":"Bunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naderi","family":"Mersaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/archneurol.2011.157","article-title":"Ecology of the aging human brain","volume":"68","author":"JA Sonnen","year":"2011","journal-title":"Arch Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease","volume":"106","author":"J Yao","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"67808","DOI":"10.18632\/oncotarget.12179","article-title":"High fat diet exacerbates Alzheimer's disease-related pathology in APPswe\/PS1 mice","volume":"42","author":"P Th\u00e9riault","year":"2016","journal-title":"Oncotarget"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.arcmed.2012.11.009","article-title":"Early-onset Alzheimer\u2019s disease: nonamnestic subtypes and type 2 AD","volume":"43","author":"MF Mendez","year":"2012","journal-title":"Archives of Medical Research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1601-0825.2011.01830.x","article-title":"Caloric restriction and chronic inflammatory diseases","volume":"18","author":"O Gonz\u00e1lez","year":"2012","journal-title":"Oral Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1249\/MSS.0000000000000612","article-title":"Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease","volume":"47","author":"J Cho","year":"2015","journal-title":"Medicine & Science in Sports & Exercise"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.psyneuen.2014.03.021","article-title":"Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms","volume":"45","author":"Y Garc\u00eda-Mesa","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1002\/oby.20037","article-title":"Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China","volume":"21","author":"M Loef","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10863-005-6631-3","article-title":"Gradual alteration of mitochondrial structure and function by beta-amyloids: Importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release","volume":"37","author":"AM Aleardi","year":"2005","journal-title":"Journal of Bioenergetics and Biomembranes"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/5070","article-title":"Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides","volume":"21","author":"DJ Marsh","year":"1999","journal-title":"Nature Genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nm1611","article-title":"Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome","volume":"13","author":"LE Kuo","year":"2007","journal-title":"Nature Medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neulet.2015.11.002","article-title":"Early alterations in blood and brain RANTES and MCP-1 expression and the effect of exercise frequency in the 3xTg-AD mouse model of Alzheimer's disease","volume":"610","author":"M Haskins","year":"2016","journal-title":"Neurosci Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s Disease with plaques and tangles: Intracellular A\u03b2 and synaptic dysfunction","volume":"39","author":"S Oddo","year":"2003","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nn.3207","article-title":"Rho-kinase regulates energy balance by targeting leptin receptor signaling","volume":"15","author":"H Huang","year":"2012","journal-title":"Nature Neuroscience"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jocn.2003.12.007","article-title":"Alzheimer's disease pathogenesis and therapeutic interventions","volume":"11","author":"MS Parihar","year":"2004","journal-title":"J Clin Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer\u2019s disease","volume":"8","author":"FM LaFerla","year":"2007","journal-title":"Nature Reviews Neuroscience"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats","volume":"18","author":"AM Stranahan","year":"2008","journal-title":"Hippocampus"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"JP Thaler","year":"2012","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ncb2562","article-title":"IKKbeta\/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes","volume":"14","author":"J Li","year":"2012","journal-title":"Nature Cell Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"MW Schwartz","year":"2000","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/nn.4372","article-title":"Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis","volume":"19","author":"X Zhang","year":"2016","journal-title":"Nat Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/en.2002-220866","article-title":"Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance","volume":"144","author":"LE Pritchard","year":"2003","journal-title":"Endocrinology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-2011-101635","article-title":"Physical exercise protects against Alzheimer\u2019s disease in 3xTg-AD mice","volume":"24","author":"Y Garcia-Mesa","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1523\/JNEUROSCI.0496-05.2005","article-title":"Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease","volume":"27","author":"PA Adlard","year":"2005","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1152\/jn.00277.2005","article-title":"Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus","volume":"94","author":"K Jackson","year":"2005","journal-title":"Journal of Neurophysiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/JOE-15-0510","article-title":"Voluntary exercise improves hypothalamic and metabolic function in obese mice","volume":"229","author":"BT Laing","year":"2016","journal-title":"J Endocrinol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T23:17:05Z","timestamp":1570576625000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190205"}},"subtitle":[],"editor":[{"given":"Guillermo","family":"L\u00f3pez Lluch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190205","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}