{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:09:05Z","timestamp":1776197345024,"version":"3.50.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190229","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:11:34Z","timestamp":1513872694000},"page":"e0190229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Annexin A5 reduces early plaque formation in ApoE -\/- mice"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-2554","authenticated-orcid":true,"given":"Robert","family":"St\u00f6hr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Schurgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"van Gorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armand","family":"Jaminon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Reutelingsperger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"issue":"6917","key":"ref1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"P Libby","year":"2002","journal-title":"Nature"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrneph.2017.51","article-title":"The immunology of atherosclerosis","volume":"13","author":"A Gistera","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni.2001","article-title":"The immune system in atherosclerosis","volume":"12","author":"GK Hansson","year":"2011","journal-title":"Nat Immunol"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"P Libby","year":"2002","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","article-title":"ESC\/EAS Guidelines for the Management of Dyslipidaemias","volume":"2016","author":"Alberico L. Catapano","year":"2016","journal-title":"European Heart Journal"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/CS20150027","article-title":"Cellular and molecular mechanisms of statins: an update on pleiotropic effects","volume":"129","author":"M Satoh","year":"2015","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri2675","article-title":"Macrophage death and defective inflammation resolution in atherosclerosis","volume":"10","author":"I Tabas","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.bbamcr.2008.01.030","article-title":"Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization","volume":"1783","author":"HO van Genderen","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/ATVBAHA.110.216747","article-title":"Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice","volume":"31","author":"MM Ewing","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.atherosclerosis.2012.01.037","article-title":"Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice","volume":"221","author":"MM Ewing","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref11","first-page":"22","article-title":"Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated pro-inflammation and coagulation","author":"JH Park","year":"2016","journal-title":"Mol Med"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006778","article-title":"Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60","volume":"6","author":"M Rahman","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1111\/jcmm.12374","article-title":"AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-\/-) mice","volume":"18","author":"M Burgmaier","year":"2014","journal-title":"J Cell Mol Med"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"e96749","DOI":"10.1371\/journal.pone.0096749","article-title":"Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake","volume":"9","author":"L Ungethum","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1006\/bbrc.1999.1752","article-title":"Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells","volume":"265","author":"C Gidon-Jeangirard","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"16","key":"ref16","doi-asserted-by":"crossref","first-page":"10474","DOI":"10.1074\/jbc.272.16.10474","article-title":"Inhibition of cytosolic phospholipase A2 by annexin V in differentiated permeabilized HL-60 cells. Evidence of crucial importance of domain I type II Ca2+-binding site in the mechanism of inhibition","volume":"272","author":"JP Mira","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/10739680701653517","article-title":"Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibition","volume":"15","author":"MJ Kuijpers","year":"2008","journal-title":"Microcirculation"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"e43229","DOI":"10.1371\/journal.pone.0043229","article-title":"Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype","volume":"7","author":"LJ Schurgers","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/ATVBAHA.110.221127","article-title":"Monocyte and macrophage dynamics during atherogenesis","volume":"31","author":"K Ley","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T08:14:19Z","timestamp":1570522459000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190229"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190229","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,21]]}}}