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Endocrinol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12011-010-8625-1","article-title":"A comparative study of the oxidative profile in Graves\u2019 disease, Hashimoto\u2019s thyroiditis, and papillary thyroid cancer","volume":"138","author":"S Lassoued","year":"2010","journal-title":"Biol Trace Elem Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1006\/bbrc.1997.6378","article-title":"Regulation of expression of leptin mRNA and secretion of leptin by thyroid hormone in 3T3-L1 adipocytes","volume":"232","author":"T Yoshida","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1113\/jphysiol.2009.172510","article-title":"Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue","volume":"587","author":"CR Gonz\u00e1lez","year":"2009","journal-title":"J Physiol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2265.2009.03546.x","article-title":"Plasma visfatin concentrations increase in both hyper and hypothyroid subjects after normalization of thyroid function and are not related to insulin resistance, anthropometric or inflammatory parameters","volume":"71","author":"A Caix\u00e0s","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"R920","DOI":"10.1152\/ajpregu.00520.2006","article-title":"Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance","volume":"292","author":"PVG Katakam","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to 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