{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:35:10Z","timestamp":1784687710756,"version":"3.55.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190409","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T14:19:49Z","timestamp":1515680389000},"page":"e0190409","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Disease burden of methylmercury in the German birth cohort 2014"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-5455","authenticated-orcid":true,"given":"Julia","family":"Lackner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"M\u00fcller-Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s001030050148","article-title":"Stoffmonographie Quecksilber\u2013Referenz- und Human- Biomonitoring-Werte (HBM)","volume":"42","year":"1999","journal-title":"Bundesgesundheitsblatt\u2014Gesundheitsforschung\u2014Gesundheitsschutz"},{"key":"ref2","article-title":"Toxicological Effects of Methylmercury","year":"2000"},{"key":"ref3","article-title":"Klimawandel bedingte Aufnahme von toxischem Methylquecksilber \u00fcber den Fischkonsum","author":"R Kruse","year":"2008"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.yrtph.2008.01.016","article-title":"Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers","volume":"51","author":"AF Castoldi","year":"2008","journal-title":"Regulatory toxicology and pharmacology: RTP"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0361-9230(01)00458-0","article-title":"Neurotoxicity and molecular effects of methylmercury","volume":"55","author":"AF Castoldi","year":"2001","journal-title":"Brain Research Bulletin"},{"key":"ref6","unstructured":"Costa LG, Fattori, V. Health Risks associated with Fish Consumption. Focus on Methylmercury, Dioxins ans Dioxin-Like PCBS. Rom; FAO &amp; WHO, 2010 25.-29. January 2010. Report No.; EC:RBFC\/2010\/3."},{"key":"ref7","article-title":"Mercury: Assessing the environmental burden of disease at national and local levels","volume":"16","author":"J Poulin","year":"2008","journal-title":"WHO Environmental Burden of Disease Series"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1289\/ehp.9303","article-title":"Dose-response relationship of prenatal mercury exposure and IQ: an integrative analysis of epidemiologic data","volume":"115","author":"DA Axelrad","year":"2007","journal-title":"Environmental health perspectives"},{"key":"ref9","article-title":"Foodborne Disease Burden Epidemiology Reference Group 2007\u20132015","year":"2015"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fct.2012.01.013","article-title":"Fish, contaminants and human health: quantifying and weighing benefits and risks","volume":"54","author":"J Hoekstra","year":"2013","journal-title":"Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association"},{"key":"ref11","unstructured":"Kruse R, Bartelt, S. Exposition mit Methylquecksilber durch Fischverzehr und Etablierung analytischer Methoden zur Bestimmung von Methylquecksilber in Fischereierzeugnissen. Cuxhaven; 2008."},{"key":"ref12","article-title":"The ICD-10 Classification of Mental and Behavioural Disorders: Clinical descriptions and diagnostic guidelines","year":"1992"},{"key":"ref13","unstructured":"Deutsche Gesellschaft f\u00fcr Kinder- und Jugendpsychiatrie Psychosomatik und Psychotherapie. S2k Praxisleitlinie Intelligenzminderung; 2014 [12\/2014]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.awmf.org\/uploads\/tx_szleitlinien\/028-042l_S2k_Intelligenzminderung_2014-12.pdf\" xlink:type=\"simple\">http:\/\/www.awmf.org\/uploads\/tx_szleitlinien\/028-042l_S2k_Intelligenzminderung_2014-12.pdf<\/ext-link>."},{"key":"ref14","unstructured":"World Health Organization. Evaluation of certain Food Additives and Contaminants Geneva; 2004."},{"key":"ref15","article-title":"Guidance for identifying population at risk from mercury exposure","year":"2008"},{"key":"ref16","article-title":"Aufnahme von Umweltkontaminanten \u00fcber Lebensmittel: Ergebnisse des Forschungsprojektes LExUKon","year":"2010"},{"key":"ref17","unstructured":"Max Rubner-Institut. Nationale Verzehrsstudie II. Karlsruhe: Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft; 2008."},{"key":"ref18","unstructured":"Max Rubner-Institut. Nationale Verzehrsstudie II Karlsruhe: Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft; 2008."},{"key":"ref19","unstructured":"Schwarz M, Schneider, K., Lindtner, O., Blume, K., Fiddicke, U., Heinemeyer, G. LExUKon\u2014Bericht zur Expositionssch\u00e4tzung von Quecksilber. 2010."},{"key":"ref20","article-title":"Fischwirtschaft: Daten und Fakten","year":"2016"},{"key":"ref21","unstructured":"Salling KB. Risk Analysis and Monte Carlo Simulation within Transport Appraisal. Lyngby; Technical University of Denmark, 2007."},{"key":"ref22","article-title":"Berichte zur Lebensmittelsicherheit 2011: Monitoring","year":"2011"},{"key":"ref23","unstructured":"Blume K. Verzehrsdaten zu Fisch bei Frauen und Schwangeren zur Berechnung der Krankheitslast durch Methylquecksilber. Aggregierte Datenzusammenstellung aus der Nationalen Verzehrsstudie II (NVS II) Personal Communication: 26.04.2016."},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ijfoodmicro.2010.07.011","article-title":"Evaluating variability and uncertainty in microbial quantitative risk assessment using two R packages","volume":"142","author":"R Pouillot","year":"2010","journal-title":"International journal of food microbiology"},{"key":"ref25","article-title":"R: A language and environment for statistical computing","year":"2017"},{"key":"ref26","unstructured":"Statistisches Bundesamt. Lebendgeborene: Deutschland, Monate, Geschlecht; 2016. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www-genesis.destatis.de\/genesis\/online;jsessionid=C151886C1C656B473CE4DEEBE64CD340.tomcat_GO_1_1?operation=previous&levelindex=2&levelid=1476782780173&step=2\" xlink:type=\"simple\">https:\/\/www-genesis.destatis.de\/genesis\/online;jsessionid=C151886C1C656B473CE4DEEBE64CD340.tomcat_GO_1_1?operation=previous&amp;levelindex=2&amp;levelid=1476782780173&amp;step=2<\/ext-link>."},{"issue":"3","key":"ref27","first-page":"429","article-title":"Quantifying the burden of disease: the technical basis for disability-adjusted life years","volume":"72","author":"CJ Murray","year":"1994","journal-title":"Bulletin of the World Health Organization"},{"issue":"6","key":"ref28","first-page":"703","article-title":"Understanding DALYs (disability-adjusted life years)","volume":"16","author":"CJ Murray","year":"1997","journal-title":"Journal of health economics"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"e79740","DOI":"10.1371\/journal.pone.0079740","article-title":"The pathogen- and incidence-based DALY approach: an appropriate [corrected] methodology for estimating the burden of infectious diseases","volume":"8","author":"MJ Mangen","year":"2013","journal-title":"PloS one"},{"key":"ref30","unstructured":"Statistisches Bundesamt. Sterbetafel 2012\/2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.destatis.de\/DE\/ZahlenFakten\/GesellschaftStaat\/Bevoelkerung\/Sterbefaelle\/AktuellPeriodensterbetafeln.html\" xlink:type=\"simple\">https:\/\/www.destatis.de\/DE\/ZahlenFakten\/GesellschaftStaat\/Bevoelkerung\/Sterbefaelle\/AktuellPeriodensterbetafeln.html<\/ext-link>."},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"M470","DOI":"10.1093\/gerona\/57.7.M470","article-title":"The influence of intellectual disability on life expectancy","volume":"57","author":"AH Bittles","year":"2002","journal-title":"The journals of gerontology Series A, Biological sciences and medical sciences"},{"issue":"Pt 5","key":"ref32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-2788.2000.00280.x","article-title":"Life expectancy of people with intellectual disability: a 35-year follow-up study","volume":"44","author":"K Patja","year":"2000","journal-title":"Journal of intellectual disability research: JIDR"},{"key":"ref33","unstructured":"World Health Organization. Global Burden of Disease 2004 Update: Disability Weights for Disease and Conditions. 2004."},{"key":"ref34","unstructured":"Devleesschauwer B, McDonald, S., Haagsma, J., Praet, N., Havelaar, A., Speybroeck, N. The DALY Calculator\u2014Graphical User Interface for Probabilistic DALY calculation in R. 2016;R package version 1.5.0."},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1289\/ehp.7857","article-title":"New Evidence on Variations of Human Body Burden of Methylmercury from Fish Consumption","volume":"114","author":"R Canuel","year":"2006","journal-title":"Environmental health perspectives"},{"key":"ref36","unstructured":"The World Bank. Population, total; 2014 [28.10.2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/data.worldbank.org\/indicator\/SP.POP.TOTL\" xlink:type=\"simple\">http:\/\/data.worldbank.org\/indicator\/SP.POP.TOTL<\/ext-link>."},{"key":"ref37","unstructured":"Verbrauchertipp f\u00fcr Schwangere und Stillende, den Verzehr von Thunfisch einzuschr\u00e4nken, hat weiterhin G\u00fcltigkeit [Internet]. 2008; 10. September 2008. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bfr.bund.de\/cm\/343\/verbrauchertipp_fuer_schwangere_und_stillende_den_verzehr_von_thunfisch_einzuschraenken.pdf\" xlink:type=\"simple\">http:\/\/www.bfr.bund.de\/cm\/343\/verbrauchertipp_fuer_schwangere_und_stillende_den_verzehr_von_thunfisch_einzuschraenken.pdf<\/ext-link>"},{"key":"ref38","article-title":"WHO methods and data sources for global burden of disease estimates 2000\u20132011","year":"2013"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuro.2005.12.005","article-title":"Relationship between platelet monoamine oxidase-B (MAO-B) activity and mercury exposure in fish consumers from the Lake St. Pierre region of Que., Canada","volume":"27","author":"CJ Stamler","year":"2006","journal-title":"NeuroToxicology"},{"key":"ref40","first-page":"29","article-title":"Europ\u00e4ische Human-Biomonitoring Pilotstudie DEMOCOPHES: Umweltbelastung von M\u00fcttern und Kindern","volume":"1","author":"G Schwedler","year":"2013","journal-title":"UMWELT und MENSCH\u2014INFORMATIONSDIENST"},{"key":"ref41","unstructured":"Umweltbundesamt. Europ\u00e4ische Studie zur Umweltbelastung von M\u00fcttern und Kindern: Erste Ergebnisse aus DEMOCOPHES Dessau-Ro\u00dflau; 2012. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umweltbundesamt.de\/sites\/default\/files\/medien\/pdfs\/democophes_umweltbelastung_von_muettern_und_kindern_ergebnisse.pdf\" xlink:type=\"simple\">https:\/\/www.umweltbundesamt.de\/sites\/default\/files\/medien\/pdfs\/democophes_umweltbelastung_von_muettern_und_kindern_ergebnisse.pdf<\/ext-link>."},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1078\/1438-4639-00155","article-title":"German Environmental Survey 1998 (GerES III): environmental pollutants in blood of the German population","volume":"205","author":"K Becker","year":"2002","journal-title":"International journal of hygiene and environmental health"},{"key":"ref43","article-title":"Estimates for Nine Stressors in Six European Countries","author":"O H\u00e4nninen","year":"2011"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2222.2007.02685.x","article-title":"Maternal fish intake during pregnancy and atopy and asthma in infancy","volume":"37","author":"I Romieu","year":"2007","journal-title":"Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T10:50:28Z","timestamp":1540032628000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190409"}},"subtitle":[],"editor":[{"given":"Yi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190409","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}