{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:58Z","timestamp":1793381098475,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI093577"],"award-info":[{"award-number":["AI093577"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190453","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T13:32:00Z","timestamp":1516887120000},"page":"e0190453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mast cell heterogeneity underlies different manifestations of food allergy in mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Sara","family":"Bened\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-9249","authenticated-orcid":true,"given":"M. Cecilia","family":"Berin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"SJ Galli","year":"2012","journal-title":"Nature medicine"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","article-title":"Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment","volume":"133","author":"SH Sicherer","year":"2014","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.annemergmed.2006.01.018","article-title":"Second symposium on the definition and management of anaphylaxis: summary report\u2014second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"47","author":"HA Sampson","year":"2006","journal-title":"Ann Emerg Med"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1056\/NEJMoa070030","article-title":"Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis","volume":"358","author":"P Vadas","year":"2008","journal-title":"The New England journal of medicine"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jaci.2009.03.012","article-title":"Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions","volume":"124","author":"K Arias","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2012.08.016","article-title":"Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis","volume":"131","author":"P Vadas","year":"2012","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1172\/JCI19785","article-title":"Mast cells are required for experimental oral allergen-induced diarrhea","volume":"112","author":"EB Brandt","year":"2003","journal-title":"The Journal of clinical investigation"},{"issue":"34","key":"ref8","doi-asserted-by":"crossref","first-page":"14210","DOI":"10.1073\/pnas.1111048108","article-title":"Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue","volume":"108","author":"W Xing","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/mi.2009.136","article-title":"Advances in mast cell biology: new understanding of heterogeneity and function","volume":"3","author":"TC Moon","year":"2010","journal-title":"Mucosal immunology"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jlb.61.3.233","article-title":"Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase","volume":"61","author":"M Welle","year":"1997","journal-title":"J Leukoc Biol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2012.07.003","article-title":"Developmental origin and functional specialization of mast cell subsets","volume":"37","author":"MF Gurish","year":"2012","journal-title":"Immunity"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"G1234","DOI":"10.1152\/ajpgi.00323.2007","article-title":"CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice","volume":"293","author":"AK Knight","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jaci.2012.04.009","article-title":"Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa","volume":"129","author":"SA Leonard","year":"2012","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.160.11.5537","article-title":"Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis","volume":"160","author":"DS Friend","year":"1998","journal-title":"J Immunol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaci.2008.10.001","article-title":"Targeting IL-4\/IL-13 signaling to alleviate oral allergen-induced diarrhea","volume":"123","author":"EB Brandt","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1398-9995.2006.01012.x","article-title":"Role of TLR4 in allergic sensitization to food proteins in mice","volume":"61","author":"MC Berin","year":"2006","journal-title":"Allergy"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.ajpath.2011.12.036","article-title":"Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice","volume":"180","author":"R Ahrens","year":"2012","journal-title":"Am J Pathol"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1172\/JCI77798","article-title":"Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis","volume":"124","author":"H Han","year":"2014","journal-title":"The Journal of clinical investigation"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1002\/1521-4141(200009)30:9<2660::AID-IMMU2660>3.0.CO;2-I","article-title":"MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice","volume":"30","author":"M Poorafshar","year":"2000","journal-title":"Eur J Immunol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jaci.2013.06.008","article-title":"Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice","volume":"132","author":"LL Reber","year":"2013","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.4049\/jimmunol.179.10.6696","article-title":"Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses","volume":"179","author":"J Sun","year":"2007","journal-title":"J Immunol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00281-012-0320-1","article-title":"Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity","volume":"34","author":"SP Hogan","year":"2012","journal-title":"Semin Immunopathol"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1084\/jem.20170910","article-title":"The transcriptional program, functional heterogeneity, and clinical targeting of mast cells","volume":"214","author":"G Cildir","year":"2017","journal-title":"The Journal of experimental medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxlet.2016.09.005","article-title":"Evaluation of the sensitizing potential of food proteins using two mouse models","volume":"262","author":"J Smit","year":"2016","journal-title":"Toxicol Lett"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/mi.2012.112","article-title":"Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy","volume":"6","author":"OT Burton","year":"2013","journal-title":"Mucosal immunology"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jaci.2011.01.034","article-title":"Ingested allergens must be absorbed systemically to induce systemic anaphylaxis","volume":"127","author":"RT Strait","year":"2011","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jaci.2011.01.057","article-title":"Mechanisms underlying differential food allergy response to heated egg","volume":"127","author":"G Martos","year":"2011","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1398-9995.2008.01673.x","article-title":"Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer&apos;s patches","volume":"63","author":"F Roth-Walter","year":"2008","journal-title":"Allergy"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.4049\/jimmunol.140.6.1953","article-title":"Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells","volume":"140","author":"DJ Heavey","year":"1988","journal-title":"J Immunol"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.4049\/jimmunol.178.7.4177","article-title":"FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells","volume":"178","author":"M Ekoff","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"KR Groschwitz","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.immuni.2015.08.020","article-title":"Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy","volume":"43","author":"CY Chen","year":"2015","journal-title":"Immunity"},{"issue":"52","key":"ref33","doi-asserted-by":"crossref","first-page":"22381","DOI":"10.1073\/pnas.0906372106","article-title":"Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase\/Mcpt4-dependent mechanism","volume":"106","author":"KR Groschwitz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.4049\/jimmunol.172.11.6978","article-title":"Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy","volume":"172","author":"ME Bashir","year":"2004","journal-title":"J Immunol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4049\/jimmunol.171.1.390","article-title":"Mast cells in airway hyporesponsive C3H\/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters","volume":"171","author":"L Li","year":"2003","journal-title":"J Immunol"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1074\/jbc.M111.320580","article-title":"The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development","volume":"287","author":"M Zhu","year":"2012","journal-title":"J Biol Chem"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1073\/pnas.1501554112","article-title":"Coincidental loss of DOCK8 function in NLRP10-deficient and C3H\/HeJ mice results in defective dendritic cell migration","volume":"112","author":"JK Krishnaswamy","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","article-title":"Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern","author":"AC Boos","year":"2014","journal-title":"Allergy"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jaci.2011.03.044","article-title":"Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice","volume":"127","author":"K Arias","year":"2011","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"30","key":"ref40","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1073\/pnas.1105695108","article-title":"Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis","volume":"108","author":"MV Khodoun","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jaci.2016.02.015","article-title":"Human IgE-independent systemic anaphylaxis","volume":"137","author":"FD Finkelman","year":"2016","journal-title":"The Journal of allergy and clinical immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T15:06:09Z","timestamp":1719759969000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190453"}},"subtitle":[],"editor":[{"given":"Edda","family":"Fiebiger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190453","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]}}}