{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:23:52Z","timestamp":1789122232352,"version":"build-2803163510"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006221","name":"Cordis","doi-asserted-by":"publisher","award":["621394"],"award-info":[{"award-number":["621394"]}],"id":[{"id":"10.13039\/501100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["4135"],"award-info":[{"award-number":["4135"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190474","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T15:51:53Z","timestamp":1515167513000},"page":"e0190474","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-2476","authenticated-orcid":true,"given":"Asier","family":"Gal\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Bari\u0107","family":"Rafaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kre\u0161o","family":"Bendelja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velimir","family":"Su\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Joaqu\u00edn","family":"Cer\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Mrljak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"issue":"1\u20132","key":"ref1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetpar.2006.01.041","article-title":"Immune control of <italic>Babesia<\/italic> bovis infection","volume":"138","author":"WC Brown","year":"2006","journal-title":"Veterinary Parasitology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4102\/ojvr.v76i1.66","article-title":"Canine babesiosis","volume":"76","author":"JP Schoeman","year":"2009","journal-title":"Onderstepoort Journal of Veterinary Research"},{"issue":"1\u20132","key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.vetpar.2006.01.035","article-title":"<italic>Babesia<\/italic>\u2014A historical overview","volume":"138","author":"G Uilenberg","year":"2006","journal-title":"Veterinary Parasitology"},{"key":"ref4","first-page":"3","article-title":"Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections","author":"L Cardoso","year":"2010","journal-title":"Parasites & Vectors"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/jvim.12146","article-title":"Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis","volume":"27","author":"R Bari\u0107 Rafaj","year":"2013","journal-title":"J Vet Intern Med"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ijpara.2008.12.005","article-title":"Diversity of <italic>Babesia<\/italic> and Theileria species in symptomatic and asymptomatic dogs in Croatia","volume":"39","author":"R VL Beck","year":"2009","journal-title":"Int J Parasitol"},{"issue":"1\u20132","key":"ref7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetpar.2006.05.002","article-title":"Capillary and venous <italic>Babesia canis rossi<\/italic> parasitaemias and their association with outcome of infection and circulatory compromise","volume":"141","author":"M Bohm","year":"2006","journal-title":"Veterinary Parasitology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1939-1676.2004.tb02544.x","article-title":"Prevalence and risk factors of hypoglycemia in virulent canine babesiosis","volume":"18","author":"N Keller","year":"2004","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4102\/jsava.v72i3.640","article-title":"Systemic inflammatory response syndrome and multiple-organ damage\/dysfunction in complicated canine babesiosis","volume":"72","author":"C Welzl","year":"2001","journal-title":"Journal of the South African Veterinary Association-Tydskrif Van Die Suid-Afrikaanse Veterinere Vereniging"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1128\/JCM.01110-08","article-title":"Preliminary Evaluation of the BrEMA1 Gene as a Tool for Associating <italic>Babesia rossi<\/italic> Genotypes and Clinical Manifestation of Canine Babesiosis","volume":"47","author":"PT Matjila","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2011.04.023","article-title":"Babesiosis in dogs and cats-Expanding parasitological and clinical spectra","volume":"181","author":"L Solano-Gallego","year":"2011","journal-title":"Veterinary Parasitology"},{"issue":"1\u20132","key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.vetpar.2009.02.002","article-title":"Detection of erythrocyte binding IgM and IgG by flow cytometry in sick dogs with <italic>Babesia canis canis<\/italic> or <italic>Babesia canis vogeli<\/italic> infection","volume":"162","author":"E Carli","year":"2009","journal-title":"Veterinary Parasitology"},{"issue":"3\u20134","key":"ref13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetpar.2008.07.024","article-title":"Babesia canis canis and <italic>Babesia canis vogeli<\/italic> clinicopathological findings and DNA detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease","volume":"157","author":"L Solano-Gallego","year":"2008","journal-title":"Veterinary Parasitology"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1939-1676.2004.tb02573.x","article-title":"Efficacy of combined atovaquone and azithromycin for therapy of chronic <italic>Babesia gibsoni<\/italic> (Asian genotype) infections in dogs","volume":"18","author":"AJ Birkenheuer","year":"2004","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2460\/javma.2005.227.942","article-title":"Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000\u20132003)","volume":"227","author":"AJ Birkenheuer","year":"2005","journal-title":"Javma-Journal of the American Veterinary Medical Association"},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vetpar.2006.01.044","article-title":"<italic>Babesia conradae<\/italic>, sp Nov., a small canine <italic>Babesia<\/italic> identified in California","volume":"138","author":"AM Kjemtrup","year":"2006","journal-title":"Veterinary Parasitology"},{"issue":"2","key":"ref17","first-page":"141","article-title":"Azotemia and mortality among <italic>Babesia microti-<\/italic>like infected dogs","volume":"18","author":"AT Camacho","year":"2004","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"3\u20134","key":"ref18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.vetpar.2006.10.004","article-title":"Evidence of an acute phase response in dogs naturally infected with <italic>Babesia canis<\/italic>","volume":"144","author":"V Matijatko","year":"2007","journal-title":"Veterinary Parasitology"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0195-5616(03)00039-1","article-title":"Canine babesiosis","volume":"33","author":"AL Boozer","year":"2003","journal-title":"Veterinary Clinics of North America-Small Animal Practice"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.exppara.2015.08.002","article-title":"Clinical, haematological, cytokine and acute phase protein changes during experimental <italic>Babesia gibsoni<\/italic> infection of beagle puppies","volume":"157","author":"AL Brown","year":"2015","journal-title":"Experimental Parasitology"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1128\/CVI.00475-07","article-title":"Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region","volume":"15","author":"AA Morais Fernandes","year":"2008","journal-title":"Clinical and Vaccine Immunology"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1034\/j.1399-6576.2003.00004.x","article-title":"Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis","volume":"47","author":"P Loisa","year":"2003","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/14787210.2016.1224971","article-title":"Pathogenic, immunologic, and clinical aspects of sepsis\u2014update 2016","volume":"14","author":"F Uhle","year":"2016","journal-title":"Expert Review of Anti-Infective Therapy"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1476-4431.2009.00489.x","article-title":"Clinical management of canine babesiosis","volume":"20","author":"AL Ayoob","year":"2010","journal-title":"Journal of Veterinary Emergency and Critical Care"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1475-2875-5-85","article-title":"Human malarial disease: a consequence of inflammatory cytokine release","volume":"5","author":"IA Clark","year":"2006","journal-title":"Malaria Journal"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1939-1676.2001.tb01573.x","article-title":"The mixed acid-base disturbances of severe canine babesiosis","volume":"15","author":"AL JL Leisewitz","year":"2001","journal-title":"J Vet Intern Med"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.17221\/77\/2010-VETMED","article-title":"Malondialdehyde levels in serum of dogs infected with <italic>Babesia canis<\/italic>","volume":"55","author":"M Crnogaj","year":"2010","journal-title":"Veterinarni Medicina"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.rvsc.2014.07.010","article-title":"Relationship between paraoxonase 1 activity and high density lipoprotein concentration during naturally occurring babesiosis in dogs","volume":"97","author":"G Rossi","year":"2014","journal-title":"Research in Veterinary Science"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.pt.2007.09.005","article-title":"Shared features in the pathobiology of babesiosis and malaria","volume":"23","author":"PJ Krause","year":"2007","journal-title":"Trends in Parasitology"},{"issue":"5","key":"ref30","first-page":"611","article-title":"Systemic inflammatory response syndrome and multiple organ dysfunction syndrome in canine babesiosis","volume":"80","author":"V Matijatko","year":"2010","journal-title":"Veterinarski Arhiv"},{"issue":"6","key":"ref31","first-page":"1145","article-title":"Cytokines in the pathogenesis of and protection against malaria","volume":"9","author":"I Angulo","year":"2002","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cyto.2013.08.007","article-title":"Dysregulation of cytokines expression in complicated falciparum malaria with increased TGF-beta and IFN-gamma and decreased IL-2 and IL-12","volume":"64","author":"SD Lourembam","year":"2013","journal-title":"Cytokine"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1165\/rcmb.2012-0450OC","article-title":"Hemozoin Induces Lung Inflammation and Correlates with Malaria-Associated Acute Respiratory Distress Syndrome","volume":"48","author":"K Deroost","year":"2013","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"ref34","first-page":"12","article-title":"Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum","author":"C Noone","year":"2013","journal-title":"Malaria Journal"},{"issue":"3","key":"ref35","first-page":"134","article-title":"The pathophysiology of canine babesiosis\u2014new approaches to an old puzzle","volume":"65","author":"LS Jacobson","year":"1994","journal-title":"Journal of the South African Veterinary Association-Tydskrif Van Die Suid-Afrikaanse Veterinere Vereniging"},{"issue":"24","key":"ref36","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1001\/jama.1992.03490240060037","article-title":"Toward an epidemiology and natural-history of sirs (systemic inflammatory response syndrome)","volume":"268","author":"RC Bone","year":"1992","journal-title":"Jama-Journal of the American Medical Association"},{"issue":"1\u20132","key":"ref37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.vetpar.2014.01.002","article-title":"Serum concentrations of eicosanoids and lipids in dogs naturally infected with <italic>Babesia canis<\/italic>","volume":"201","author":"V Mrljak","year":"2014","journal-title":"Veterinary Parasitology"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0195-5616(94)50136-0","article-title":"Systemic inflammatory response syndrome\u2014septic shock","volume":"24","author":"D Purvis","year":"1994","journal-title":"Veterinary Clinics of North America-Small Animal Practice"},{"issue":"4","key":"ref39","first-page":"369","article-title":"Serum levels of the chemokines keratinocyte chemoattractant and interleukin-8 in dogs naturally infected with <italic>Babesia canis canis<\/italic>","volume":"85","author":"I Mayer","year":"2015","journal-title":"Veterinarski Arhiv"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jvim.13822","article-title":"Prognostic Markers in Acute <italic>Babesia canis<\/italic> Infections","volume":"30","author":"RM Eichenberger","year":"2016","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2174\/092986712799828355","article-title":"Current Advances in Detection and Treatment of Babesiosis","volume":"19","author":"J Mosqueda","year":"2012","journal-title":"Current Medicinal Chemistry"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00436-014-3792-1","article-title":"Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with <italic>Babesia canis<\/italic>","volume":"113","author":"W Zygner","year":"2014","journal-title":"Parasitology Research"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"165974","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets-An Updated View","volume":"2013","author":"W Schulte","year":"2013","journal-title":"Mediators of Inflammation"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte Chemoattractant Protein-1 (MCP-1): An Overview","volume":"29","author":"SL Deshmane","year":"2009","journal-title":"Journal of Interferon and Cytokine Research"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1182\/blood.V86.10.3841.bloodjournal86103841","article-title":"Plasma levels of the chemokines monocyte chemotactic protein-1 and protein-2 are elevated in human sepsis","volume":"86","author":"AWJ Bossink","year":"1995","journal-title":"Blood"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/ATVBAHA.110.205914","article-title":"Monocyte chemoattractant protein-1 deficiency protects against visceral fat-induced atherosclerosis","volume":"30","author":"MK1 WA Ohman","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tvjl.2012.09.009","article-title":"Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy","volume":"196","author":"A Goddard","year":"2013","journal-title":"Veterinary Journal"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bbrc.2004.04.056","article-title":"Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells","volume":"318","author":"B Mackness","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"E D-BO Hoffmann","year":"2002","journal-title":"J Leukoc Biol"},{"issue":"3\u20134","key":"ref50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetimm.2012.12.010","article-title":"Increased levels of interleukins 8 and 10 as findings of canine inflammatory mammary cancer","volume":"152","author":"PJ de Andres","year":"2013","journal-title":"Veterinary Immunology and Immunopathology"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/sj.ijo.0803259","article-title":"Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters","volume":"30","author":"CS Kim","year":"2006","journal-title":"International Journal of Obesity"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0035-9203(93)90417-O","article-title":"Interleukin-8 and Plasmodium falciparum malaria in Thailand","volume":"87","author":"JS Friedland","year":"1993","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"e0150113","DOI":"10.1371\/journal.pone.0150113","article-title":"Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis","volume":"11","author":"A Goddard","year":"2016","journal-title":"Plos One"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bjid.2013.08.002","article-title":"Immune responses to Leptospira infection: roles as biomarkers for disease severity","volume":"18","author":"C Chirathaworn","year":"2014","journal-title":"Brazilian Journal of Infectious Diseases"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e1965","DOI":"10.7717\/peerj.1965","article-title":"Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults","volume":"4","author":"Y Dieye","year":"2016","journal-title":"PeerJ"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1939-1676.2009.0349.x","article-title":"In Vivo and In Vitro Evidence of the Involvement of CXCL1, a Keratinocyte-Derived Chemokine, in Equine Laminitis","volume":"23","author":"RR Faleiros","year":"2009","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"32188","DOI":"10.1038\/srep32188","article-title":"Effects of IL-1 beta, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity","volume":"6","author":"J Bester","year":"2016","journal-title":"Scientific Reports"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.clim.2010.02.023","article-title":"Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients","volume":"136","author":"D Nebor","year":"2010","journal-title":"Clinical Immunology"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/jvim.12409","article-title":"N-Terminal Pro-C-Natriuretic Peptide and Cytokine Kinetics in Dogs with Endotoxemia","volume":"28","author":"ANK Floras","year":"2014","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13054-015-0778-z","article-title":"The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation","volume":"19","author":"TA Mare","year":"2015","journal-title":"Critical care (London, England)"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.vetimm.2016.01.005","article-title":"Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis","volume":"170","author":"I Karlsson","year":"2016","journal-title":"Veterinary Immunology and Immunopathology"},{"issue":"10","key":"ref62","doi-asserted-by":"crossref","first-page":"e46553","DOI":"10.1371\/journal.pone.0046553","article-title":"Induction of IL-10-Producing CD1d(high)CD(5+) Regulatory B Cells following <italic>Babesia microti<\/italic>-Infection","volume":"7","author":"Y-I Jeong","year":"2012","journal-title":"Plos One"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1086\/315214","article-title":"Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options","volume":"181","author":"CA Gogos","year":"2000","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/504720","article-title":"Clusters of cytokines determine malaria severity in Plasmodium falciparum\u2014Infected patients from endemic areas of central India","volume":"194","author":"D Prakash","year":"2006","journal-title":"Journal of Infectious Diseases"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1128\/IAI.69.1.129-136.2001","article-title":"Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria","volume":"69","author":"J Riopel","year":"2001","journal-title":"Infection and Immunity"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4269\/ajtmh.1998.58.335","article-title":"A case study of cytokine profiles in acute human babesiosis","volume":"58","author":"MF Shaio","year":"1998","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"issue":"19","key":"ref67","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1182\/blood-2011-03-342436","article-title":"Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia","volume":"118","author":"XJ Yan","year":"2011","journal-title":"Blood"},{"issue":"4","key":"ref68","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1378\/chest.120.4.1293","article-title":"Inhibition of monocyte chemoattractant protein-1 expression in cytokine-treated human lung epithelial cells by thiazolidinedione","volume":"120","author":"A Momoi","year":"2001","journal-title":"Chest"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"WA Baeck C","year":"2012","journal-title":"Gut"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T08:11:50Z","timestamp":1693383110000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190474"}},"subtitle":[],"editor":[{"given":"J. Stephen","family":"Dumler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,5]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190474","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,5]]}}}