{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:09Z","timestamp":1781719689885,"version":"3.54.5"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190478","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T14:20:46Z","timestamp":1515680446000},"page":"e0190478","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations of plasma clusterin and Alzheimer\u2019s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study"],"prefix":"10.1371","volume":"13","author":[{"given":"Thaddeus","family":"Haight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Nick","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osorio","family":"Meirelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-9860","authenticated-orcid":true,"given":"Melissa","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-7562","authenticated-orcid":true,"given":"Ilya","family":"Nasrallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Davatzikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"ref1","first-page":"25","article-title":"Genetic Variants in Alzheimer\u2019s Disease","author":"J Lord","year":"2013"},{"issue":"16","key":"ref2","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1073\/pnas.162228299","article-title":"Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer&apos;s disease","volume":"99","author":"RB DeMattos","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: a forgotten player in Alzheimer&apos;s disease","volume":"61","author":"T Nuutinen","year":"2009","journal-title":"Brain research reviews"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"e103351","DOI":"10.1371\/journal.pone.0103351","article-title":"Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation","volume":"9","author":"JC Won","year":"2014","journal-title":"PloS one"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11154-013-9275-3","article-title":"The physiological roles of apolipoprotein J\/clusterin in metabolic and cardiovascular diseases","volume":"15","author":"S Park","year":"2014","journal-title":"Reviews in endocrine & metabolic disorders"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1212\/01.wnl.0000234037.91185.99","article-title":"Association of metabolic syndrome with Alzheimer disease: A population-based study","volume":"67","author":"M Vanhanen","year":"2006","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archneur.64.1.93","article-title":"The metabolic syndrome and Alzheimer disease","volume":"64","author":"G Razay","year":"2007","journal-title":"Archives of Neurology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/156720507780362065","article-title":"The epidemiology of adiposity and dementia","volume":"4","author":"RA Whitmer","year":"2007","journal-title":"Current Alzheimer\u2019s Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11892-014-0476-2","article-title":"Alzheimer\u2019s Disease and Type 2 Diabetes: Multiple mechanisms contribute to interactions","volume":"14","author":"A Jayaraman","year":"2014","journal-title":"Currrent Diabetes Reports"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer&apos;s disease","volume":"41","author":"D Harold","year":"2009","journal-title":"Nature genetics"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer&apos;s disease","volume":"41","author":"JC Lambert","year":"2009","journal-title":"Nature genetics"},{"issue":"18","key":"ref12","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"S Seshadri","year":"2010","journal-title":"Jama"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroimage.2011.07.056","article-title":"Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment","volume":"59","author":"M Thambisetty","year":"2012","journal-title":"NeuroImage"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/archgenpsychiatry.2010.78","article-title":"Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease","volume":"67","author":"M Thambisetty","year":"2010","journal-title":"Archives of general psychiatry"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jamaneurol.2013.4560","article-title":"The role of clusterin in amyloid-beta-associated neurodegeneration","volume":"71","author":"RS Desikan","year":"2014","journal-title":"JAMA neurology"},{"issue":"13","key":"ref16","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1001\/jama.2011.381","article-title":"Plasma clusterin and the risk of Alzheimer disease","volume":"305","author":"EM Schrijvers","year":"2011","journal-title":"Jama"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer&apos;s disease-related neurofibrillary changes","volume":"16","author":"H Braak","year":"1995","journal-title":"Neurobiol Aging"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3940(96)12668-9","article-title":"Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer&apos;s disease","volume":"210","author":"H Braak","year":"1996","journal-title":"Neuroscience letters"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780195328875.001.0001","article-title":"Imaging the Aging Brain","author":"WJ Jagust","year":"2009"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006213","article-title":"Brain Imaging in Alzheimer&apos;s Disease","volume":"2","author":"K Johnson","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"GD Friedman","year":"1988","journal-title":"Journal of clinical epidemiology"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"e0122138","DOI":"10.1371\/journal.pone.0122138","article-title":"Vascular factors and multiple measures of early brain health: CARDIA brain MRI study","volume":"10","author":"LJ Launer","year":"2015","journal-title":"PloS one"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00004728-199809000-00030","article-title":"An image-processing system for qualitative and quantitative volumetric analysis of brain images","volume":"22","author":"AF Goldszal","year":"1998","journal-title":"Journal of computer assisted tomography"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.acra.2007.10.012","article-title":"Computer-assisted segmentation of white matter lesions in 3D MR images using support vector machine","volume":"15","author":"Z Lao","year":"2008","journal-title":"Academic radiology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1109\/TMI.2002.803111","article-title":"HAMMER: hierarchical attribute matching mechanism for elastic registration","volume":"21","author":"D Shen","year":"2002","journal-title":"IEEE transactions on medical imaging"},{"issue":"Pt 1","key":"ref26","first-page":"620","article-title":"Measuring brain lesion progression with a supervised tissue classification system","volume":"11","author":"EI Zacharaki","year":"2008","journal-title":"Medical image computing and computer-assisted intervention: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kabani NJ, Collins DL, Evans AC, editors. A 3D neuroanatomical atlas. Fourth International Conference on Functional Mapping of the Human Brain; 1998.","DOI":"10.1016\/S1053-8119(18)31550-7"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuroimage.2004.07.006","article-title":"Global and local gray matter loss in mild cognitive impairment and Alzheimer&apos;s disease","volume":"23","author":"GB Karas","year":"2004","journal-title":"Neuroimage"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003","article-title":"Dynamics of gray matter loss in Alzheimer&apos;s disease","volume":"23","author":"PM Thompson","year":"2003","journal-title":"J Neurosci"},{"issue":"Pt 7","key":"ref30","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/awm112","article-title":"3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer&apos;s disease","volume":"130","author":"JL Whitwell","year":"2007","journal-title":"Brain"},{"key":"ref31","article-title":"Rey Auditory-Verbal Learning Test","author":"M Schmidt","year":"1996"},{"key":"ref32","article-title":"Wechsler Adult Intelligence Scale-Revised","author":"D Wechsler","year":"1981"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reaction","volume":"18","author":"J Stroop","year":"1935","journal-title":"J Exp Psychol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/CIRCGENETICS.114.000858","article-title":"Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI","volume":"8","author":"BF Verhaaren","year":"2015","journal-title":"Circulation Cardiovascular genetics"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/oxfordjournals.aje.a115835","article-title":"Comparison of two methods of assessing physical activity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study","volume":"133","author":"S Sidney","year":"1991","journal-title":"American journal of epidemiology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1212\/01.WNL.0000106462.72282.90","article-title":"Higher atrophy rate of entorhinal cortex than hippocampus in AD","volume":"62","author":"AT Du","year":"2004","journal-title":"Neurology"},{"issue":"49","key":"ref37","doi-asserted-by":"crossref","first-page":"20954","DOI":"10.1073\/pnas.0906053106","article-title":"Subregional neuroanatomical change as a biomarker for Alzheimer\u2019s disease","volume":"106","author":"D Holland","year":"2009","journal-title":"PNAS"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1007\/s00330-009-1512-5","article-title":"Accelerating regional atropy rates in the progression from normal aging to Alzheimer\u2019s disease","volume":"19","author":"JD Sluimer","year":"2009","journal-title":"European Radiology"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/aje\/kwk017","article-title":"Sensitivity of four psychometric tests to measure cognitive changes in brain aging population-based studies","volume":"165","author":"C Proust-Lima","year":"2007","journal-title":"American journal of epidemiology"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3233\/JAD-150036","article-title":"Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer&apos;s Disease","volume":"46","author":"W Jongbloed","year":"2015","journal-title":"Journal of Alzheimer's disease: JAD"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ana.22628","article-title":"An operational approach to National Institute on Aging-Alzheimer&apos;s Association criteria for preclinical Alzheimer disease","volume":"71","author":"CR Jack Jr.","year":"2012","journal-title":"Ann Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T04:04:27Z","timestamp":1570593867000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190478"}},"subtitle":[],"editor":[{"given":"Paul B.","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190478","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}