{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:08:39Z","timestamp":1770278919100,"version":"3.49.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32 AR053459"],"award-info":[{"award-number":["T32 AR053459"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR061307"],"award-info":[{"award-number":["P30 AR061307"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K08 AR067885"],"award-info":[{"award-number":["K08 AR067885"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR56702"],"award-info":[{"award-number":["R01 AR56702"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD068373-04"],"award-info":[{"award-number":["HD068373-04"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190678","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T13:39:04Z","timestamp":1515591544000},"page":"e0190678","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Longitudinal micro-CT as an outcome measure of interstitial lung disease in TNF-transgenic mice"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-0676","authenticated-orcid":true,"given":"Richard D.","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Rudmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald W.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homaira","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.27405","article-title":"Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study","volume":"62","author":"T Bongartz","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s100670050160","article-title":"Prevalence of pulmonary disorders in patients with newly diagnosed rheumatoid arthritis","volume":"19","author":"JJ Doyle","year":"2000","journal-title":"Clin Rheumatol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00092309","article-title":"Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease","volume":"35","author":"EJ Kim","year":"2010","journal-title":"Eur Respir J"},{"issue":"135","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/09059180.00008014","article-title":"Rheumatoid arthritis-associated lung disease","volume":"24","author":"M Shaw","year":"2015","journal-title":"Eur Respir Rev"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"G Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1242\/dmm.020321","article-title":"Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume","volume":"9","author":"G Vande Velde","year":"2016","journal-title":"Dis Model Mech"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1465-9921-11-181","article-title":"Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-beta1","volume":"11","author":"T Rodt","year":"2010","journal-title":"Respir Res"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejmp.2014.05.011","article-title":"Micro-CT of rodents: state-of-the-art and future perspectives","volume":"30","author":"DP Clark","year":"2014","journal-title":"Phys Med"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1002\/j.1460-2075.1991.tb04978.x","article-title":"Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis","volume":"10","author":"J Keffer","year":"1991","journal-title":"EMBO J"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00281-003-0125-3","article-title":"The TNF-alpha transgenic mouse model of inflammatory arthritis","volume":"25","author":"P Li","year":"2003","journal-title":"Springer Semin Immunopathol"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/rccm.200410-1349OC","article-title":"Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype","volume":"171","author":"LK Lundblad","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1172\/JCI118029","article-title":"Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis","volume":"96","author":"Y Miyazaki","year":"1995","journal-title":"J Clin Invest"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13075-016-1068-0","article-title":"Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation","volume":"18","author":"M Bawadekar","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"e43123","DOI":"10.1371\/journal.pone.0043123","article-title":"Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography","volume":"7","author":"E De Langhe","year":"2012","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref15","first-page":"27","article-title":"Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis","volume":"47","author":"E Douni","year":"1995","journal-title":"J Inflamm"},{"issue":"2","key":"ref16","first-page":"712","article-title":"CXCR5(+) T helper cells mediate protective immunity against tuberculosis","volume":"123","author":"SR Slight","year":"2013","journal-title":"J Clin Invest"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"e16161","DOI":"10.1371\/journal.pone.0016161","article-title":"Profiling early lung immune responses in the mouse model of tuberculosis","volume":"6","author":"DD Kang","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"L39","DOI":"10.1152\/ajplung.2001.280.1.L39","article-title":"Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension","volume":"280","author":"M Fujita","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2147\/COPD.S108919","article-title":"Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice","volume":"11","author":"M Fujita","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ajpath.2011.12.020","article-title":"Overexpression of tumor necrosis factor-alpha in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways","volume":"180","author":"EM Thomson","year":"2012","journal-title":"Am J Pathol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","article-title":"An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure","volume":"181","author":"CC Hsia","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/01.rli.0000138134.89050.a5","article-title":"Computed tomography monitoring of radiation-induced lung fibrosis in mice","volume":"39","author":"C Plathow","year":"2004","journal-title":"Invest Radiol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2214\/AJR.15.15674","article-title":"CT in Idiopathic Pulmonary Fibrosis: Diagnosis and Beyond","volume":"206","author":"JF Gruden","year":"2016","journal-title":"AJR Am J Roentgenol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T02:41:47Z","timestamp":1570588907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190678"}},"subtitle":[],"editor":[{"given":"Heinz","family":"Fehrenbach","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190678","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]}}}