{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:58:18Z","timestamp":1740146298624,"version":"3.37.3"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI104373"],"award-info":[{"award-number":["AI104373"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI119346"],"award-info":[{"award-number":["AI119346"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL117715"],"award-info":[{"award-number":["HL117715"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL123096"],"award-info":[{"award-number":["HL123096"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI065380"],"award-info":[{"award-number":["AI065380"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0190908","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T13:27:44Z","timestamp":1519219664000},"page":"e0190908","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)"],"prefix":"10.1371","volume":"13","author":[{"given":"Benjamin Bruno","family":"Policicchio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Sette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Haret-Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Dunsmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Pandrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-7185","authenticated-orcid":true,"given":"Cristian","family":"Apetrei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"d117","DOI":"10.2741\/957","article-title":"Retroviral mutation rates and reverse transcriptase fidelity","volume":"8","author":"ES Svarovskaia","year":"2003","journal-title":"Front Biosci"},{"issue":"Suppl 1","key":"ref2","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.4081\/idr.2013.s1.e5","article-title":"HIV dug resistance: Problems and perspectives","volume":"5","author":"PS Pennings","year":"2013","journal-title":"Infect Dis Rep"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2217\/fmb.15.106","article-title":"Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection","volume":"10","author":"N Sluis-Cremer","year":"2015","journal-title":"Future Microbiol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1128\/JVI.80.10.4858-4867.2006","article-title":"Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts","volume":"80","author":"I Pandrea","year":"2006","journal-title":"J Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fimmu.2016.00012","article-title":"Animal models for HIV cure research","volume":"7","author":"BB Policicchio","year":"2016","journal-title":"Front Immunol"},{"issue":"17","key":"ref6","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1128\/JVI.00947-14","article-title":"Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors","volume":"88","author":"SA Hassounah","year":"2014","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2016.02.008","article-title":"High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo","volume":"492","author":"SB Lloyd","year":"2016","journal-title":"Virology"},{"issue":"23","key":"ref8","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.1128\/JVI.02131-15","article-title":"Characterization of the drug resistance profiles of integrase strand transfer inhibitors in simian immunodeficiency virus SIVmac239","volume":"89","author":"SA Hassounah","year":"2015","journal-title":"J Virol"},{"issue":"5683","key":"ref9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.1098632","article-title":"Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques","volume":"305","author":"DJ Hazuda","year":"2004","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1742-4690-4-25","article-title":"Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection","volume":"4","author":"KK Van Rompay","year":"2007","journal-title":"Retrovirology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1128\/JVI.78.10.5324-5337.2004","article-title":"CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment","volume":"78","author":"KK Van Rompay","year":"2004","journal-title":"J Virol"},{"year":"1996","key":"ref12","article-title":"Guide for the care and use of laboratory animals"},{"issue":"RR-2","key":"ref13","first-page":"1","article-title":"Guidelines for performing single-platform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention","volume":"52","author":"FF Mandy","year":"2003","journal-title":"MMWR Recomm Rep"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/AAC.02096-15","article-title":"Drug Susceptibility and Viral Fitness of HIV-1 with Integrase Strand Transfer Inhibitor Resistance Substitution Q148R or N155H in Combination with Nucleoside\/Nucleotide Reverse Transcriptase Inhibitor Resistance Substitutions","volume":"60","author":"KN Andreatta","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1310\/hct1202-61","article-title":"Reduced emergence of the M184V\/I resistance mutation when antiretroviral-naive subjects use emtricitabine versus lamivudine in regimens composed of two NRTIs plus the NNRTI efavirenz","volume":"12","author":"DJ McColl","year":"2011","journal-title":"HIV Clin Trials"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/QAI.0b013e3181b05f7c","article-title":"Development of HIV-1 drug resistance through 144 weeks in antiretroviral-naive subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine\/zidovudine and efavirenz in study GS-01-934","volume":"52","author":"NA Margot","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/JVI.77.2.1120-1130.2003","article-title":"Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine","volume":"77","author":"JP Murry","year":"2003","journal-title":"J Virol"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1128\/JVI.76.12.6083-6092.2002","article-title":"Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase","volume":"76","author":"KK Van Rompay","year":"2002","journal-title":"J Virol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1128\/JVI.02408-07","article-title":"Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis","volume":"82","author":"SN Gordon","year":"2008","journal-title":"J Virol"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1128\/JVI.02402-07","article-title":"Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys","volume":"82","author":"I Pandrea","year":"2008","journal-title":"Journal of Virology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40265-015-0515-6","article-title":"Modifying antiretroviral therapy in virologically suppressed HIV-1-infected patients","volume":"76","author":"SE Collins","year":"2016","journal-title":"Drugs"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/aid.2015.0130","article-title":"Short Communication: Comparative evaluation of coformulated injectable combination antiretroviral therapy regimens in simian immunodeficiency virus-infected rhesus macaques","volume":"32","author":"GQ Del Prete","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"5683","key":"ref23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.1098632","article-title":"Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques","volume":"305","author":"DJ Hazuda","year":"2004","journal-title":"Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0190908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:47:23Z","timestamp":1540342043000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0190908"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Roques","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0190908","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}